Advanced Glycation End Products (AGE's)
Advanced Glycation End Products (AGE's) are basically the nasty byproducts of glucose
metabolism. The typical Western Diet, coupled with a sedentary lifestyle,
too much fat and insulin resistance, leaves our bodies churning out excess
glucose and unable to burn it. It stays in our blood stream too long and
there does incredible damage.
One of the most damaging aspects are the Advanced
Glycation End Products (AGE's), which includes visible structures such as "liver
spots" on the skin to accumulated wastes in various tissues that interfere
with normal metabolic processes on the cellular level and lead to Inflammation,
one of our sworn arch enemies.
WARNING: AGE's have been tied to diabetes  and heart disease , both of which are
strong risk factors for erectile dysfunction. Even worse for your erections:
AGE's are tied with endothelial dysfunction, meaning less nitric oxide and blood
flow, the stuff of erections.  The good news is that AGE's have also
been linked to Alzheimer's and demenita, so you may not even remember how great
sex was, eh? 
So are there some easy ways to combat
Advanced Glycation End Products (AGE's)? Of course! As usual,
science has come to the rescue and showed us many ways to get our blood sugar
(and AGE's under control):
1. Glycemic Load. If you've read anything health-related in the last
ten years, you've probably come across an article or two about Glycemic Index.
Glycemic Index is just a fancy and rather polite way of telling you that
eating a bunch of sugar and starch is bad for you. If you understand that, then
you understand the Glycemic Index and don't need to read much from the 40,000
web pages on the subject out there.. I would like to point out that
Glycemic Load is a more relevant topic and so I recommend that you keep it in
2. Exercise. Exercise burns calories, lowers insulin resistance and
these will in short order stabilize your blood sugar.
3. Fructose. Fructose speeds up Advanced Glycation End Products.
One researcher summarized
it nicely: "This
study demonstrates that long-term fructose feeding accelerates aging as
expressed by changes in various age-related markers measured in
collagen from skin and bones."  The title of another study says it all: "Fructose
Ingestion Enhances Atherosclerosis and Deposition of Advanced Glycated
End-products in Cholesterol-fed Rabbits"  In other words,
fructose ages you internally (your arteries) and externally (your skin).
4. Vinegar. Several studies have shown that a tablespoon or maybe
two will lower blood sugar levels even after a starchy meal. One study
showed, at least in diabetics, improved insulin sensitivity after consumption of
Cinnamon. One study of diabetics, but keep in mind that most Westerners
have blood sugar issues of varying degrees, demonstrated "that intake of 1, 3,
or 6 g of cinnamon per day reduces serum glucose, triglyceride, LDL cholesterol,
and total cholesterol in people with type 2 diabetes".  This is
not a lot of cinnamon and would seem like a no-brainer to help defend against
Metabolic Disorder, Advanced Glycation End Products
(AGE's) and Heart Disease, except for one problem: there is a certain type of
"mock" cinnamon (Cassia) that has significant amounts of coumarin,
which can be poisonous to the kidneys. You only want to buy true cinnamon, which is Ceylon
6. Alpha-Lipoic Acid. Again in diabetic patients, alpha-lipoic acid
has shined, showing that it reduces glucose levels. Maintenance levels for
relatively healthy individucls is typically about 50 mg/day. 
NOTE: Alpha-lipoic Acid also has another huge benefit: increase one
of the body's primary antioxidants, glutathione. For more information, read my
link on How to Raise Levels of the Body's Natural Detoxifier.
7. Dietary Fat. Scientists found that rats fed a high fat
diet developed cholecystokinin (CCK) resistance.
 Cholecystokinin, or CCK, sends a signal to the brain, which in turn sends a
signal to the liver to decrease glucose (blood sugar) production. A high fat
diet sabotages this process, which means increased blood sugar levels for you. In other
words, you may think that you are doing your skin good by eating a diet high in
fat because you are then avoiding carbs, but this is not the case. I
noticed my skin clearing up immediately - yep, smooth as a baby's butt - when I
went on a
Low Fat Diet for example.
8) Food. Meat and fats cooked at high
temperatures actually develop AGE's. Of course, I urge great caution when
it comes to meat anyway, since consumption of all the Saturated Fat can
lead to many male health and erectile problems. But if you must eat meats,
AGE's can be reduced on the grill through various marinades.
1) Lancet,1990,336:129-33;Am. J. Cardiol,2003,91:1316-22
3) Circulation, 1992, 86:1-11
4) Diabetes Care, 2004, 27:281-282
5) Diabetes Care, 2003 Dec, 26(12):3215-8
6) Atzrieimittel-Forschung, 1995, 45:872-874
7) Arzneimittel-Forschung, 1992, 42:829-831
Cell Metabolism, Aug 6 2009, 10(2):99-109, "Intestinal Cholecystokinin Controls
Glucose Production through a Neuronal Network", Grace W.C. Cheung, et. al.
9) J of Nutr, Sep 1998, 128(9):1442-1449, "Long-Term Fructose Consumption
Accelerates Glycation and Several Age-Related Variables in Male Rats", Boaz Levi
and Moshe J. Werman
10) J Atheroscler Thromb, 2005, 12(5):260-267, "Fructose Ingestion Enhances
Atherosclerosis and Deposition of Advanced Glycated End-products in
11) Recent Progress in Hormone Research, 2001, 56:1-22, "Protein Glycation,
Diabetes, and Aging"
12) Experimental Gerontology, Jul 2007, 42(7):668-675, "Advanced glycation
endproducts: A biomarker for age as an outcome predictor after cardiac surgery?"
13) Diabetes Care, May 11 2007, 30(10):2579-2582, "Single Oral Challenge by
Advanced Glycation End Products Acutely Impairs Endothelial Function in Diabetic
and Nondiabetic Subjects"
14) Neurobiol Aging, 2009 May 21, "Advanced glycation endproducts and their
receptor RAGE in Alzheimer's disease"