Arginine, Insulin and Salt
I recently received an interesting email from a middle-aged reader. Basically, he felt strongly that even small amounts of Arginine, or
more correctly L-Arginine, made dramatic improvements in his erectile strength.
A preliminary look at the studies might lead one to believe that this was a
placebo effect, which can be significant with erectile and hormonal issues.
This is especially true since the amount that he was taking was relatively small
as well - less than 3 grams daily for sure.
L-Arginine has simply not proven so far to be a heavy hitter in the nitric
oxide/erectile dysfunction world: studies have been lackluster at best. The one
exception to this is the study where a little Arginine was coupled with
Pycnogenol and provided an excellent and relatively safe supplement solution for
guys with erectile dysfunction.
However, in spite of Arginine's checkered past, the research definitely leaves
room for it to be a significant erection-booster for some guys. For
example, one study  of patients with Type II diabetes found that just 3 grams
daily of L-Arginine dropped blood pressure very significantly, from an average of
135/87 to 123/81. This is impressive and resulted from a substantial
increase in the "erection chemical" nitric oxide. (L-Arginine is the
precursor of nitric oxide.)
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The study authors were not looking at erectile issues, but the extra nitric oxide
would have undoubtedly helped the male participants noticeably. So a key
point here is that for those with type II diabetes and/or hypertension, Arginine
may produce much more powerful results than for healthy individuals. Of
course, a huge percentage of guys in a Western society that are middle aged and
beyond are diabetic, prediabetic and/or have some hypertension
Syndrome. So L-Arginine may give a nice increase in erectile strength for
CAUTION: Talk with your doctor first and read my link about
Arginine and some of the
reservations and cautions that one should consider first.
The reason that L-Arginine helps diabetic men so much? Animal studies have
shown that L-Arginine raises nitric oxide levels much more in diabetic animals.
 In other words, "a little goes a long way" for those losing their blood
There is another mechanism by which Arginine may help the typical middle and
senior-aged guy: ADMA competition. I hope to write a page on this
soon as it is a fairly involved subject, but the important thing to realize is
that ADMA occurs naturally in our blood and directly competes with NOS, nitric
oxide synthase (the enzyme responsible for nitric oxide production). Thus
ADMA can be a significant drag on male endothelial function as the decades roll
by. In fact, ADMA
is linked to heart disease, arterial plaque, endothelial dysfunction and
possibly even erectile dysfunction as well.
Research has shown that Arginine actually helps with ADMA-related issues very
significantly. Again, this may be yet another reason that some guys get
solid results from L-Arginine.
1) Journal of the American College of Nutrition, 2002, 21(5):422-427, ""Oral
Arginine Reduces Systemic Blood Pressure in Type 2 Diabetes: Its Potential Role
in Nitric Oxide Generation"
2) DIABETES, NOV 2005, 54:3282-3287, "Reduced Nitric Oxide Concentration in the
Renal Cortex of Streptozotocin-Induced Diabetic Rats"