Please discuss everything with your doctor first.
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5) Skin Wrinkling. Many experts feel that caffeine's dehydrating effects may accelerate skin aging and wrinkling.
6) Arrythmia. Some sensitive individuals will experience heart "flutters" while on caffeine. However, it should be noted that, according to one recent meta-analysis, this is a low probability concern [6]
REFERENCES:
1) European Journal of Clinical Nutrition, 2003, 57:1411–1417, "Folic acid supplement decreases the homocysteine increasing effect of filtered coffee. A randomised placebo-controlled study"
2) Psychosomatic Medicine, 2005, 67:734-739, "Caffeine Stimulation of Cortisol Secretion Across the Waking Hours in Relation to Caffeine Intake Levels"
3) Int J Sport Nutr Exerc Metab, 2008 Apr, 18(2):131-41, "Dose effect of caffeine on testosterone and cortisol responses to resistance exercise"
4) Hypertension, 1999, 33:647–52, "The effect of chronic coffee drinking on blood pressure: a meta-analysis of controlled clinical trials"
5) Metabolism, 2006 Dec, 55(12):1564-8, "Hyperhomocysteinemia: a novel risk factor for erectile dysfunction"
6) American Journal of Clinical Nutrition, Mar 2005, 81(3):539-540, "Caffeine and arrhythmia"
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