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This researcher, Emmanuele Jannini, is the king of the G Spot and also found that PDE5 was mostly clustered around the G Spot, especially in women that had an thickened G Spot area by the way. The significance of this is that PDE5 is the same enzyme that Viagra works on in males. (PDE5 actually depletes Nitric Oxide.) In other words, most women have erectile tissue right in the area of the G Spot confirming what many enthusiastic males have been saying for years: this area can become engorged.
So what does all this mean? Well, there are a couple of important points. The first is that us males can actually learn something about females after years of intense and painful effort. The second is that it appears that some women, although no one has a hard - no pun intended of course - number, will have great difficulty achieving a vaginal orgasm because they do not have a thickened G Spot area and/or low PDE5.
Perhaps the G Spot Shot (or G Spot Augmentation) can help these women? I don't think anyone knows the answer to that question fully, but if you've been trying like a mad dog to stimulate the G Spot and nothing much is happening, there may be an anatomical reason for it. Remember that about one third of women report not being able to achieve a vaginal orgasm and perhaps this explains a lot of that phenomenon.
However, the opposite point can also be made: most women have actual erectile tissues in their vagina, Skene's glands, PDE5 and a whole lot of other fun stuff. So guys get busy if you haven't already and you can add a whole new dimension to your woman's sexuality. Most importantly, I can only encourage you to do a little "verification" of the research yourself...
NEWS FLASH: One large study of 1,800 female identical twins (Jan 2010) asked each twin if they had a G-spot. The researchers argued that if one twin had a G-Spot, the other should as well and, therefore, the answers of one twin should match the other. They actually did not find that to be the case and concluded that the G-Spot "doesn't appear to exist".  Back and forth go the arguments, eh? In my opinion, it is a flawed approach to rely on a subjective answer from a woman on this topic: many women struggle to even have an orgasm or know its location for a variety of reasons.
1) Journal of Urology, 174(4):1189-1195, H. O'CONNELL, K. SANJEEVAN, J. HUTSON, "ANATOMY OF THE CLITORIS"
2) American J of Obstetrics and Gynecology, Jan 9 2001, 185(2):359-62, "The G-spot: a modern gynecologic myth"
3) Am J Obstet Gynecol, 2001, 185:359-362
4) Urology, 2002, 60(2):1077-1082
5) J Sexual Med, published online Mar 4, 2008, Jannini, "Measurement of the Thickness of the Urethrovaginal Space in Women with or without Vaginal Orgasm."
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