Inflammation and Health
What is the #1 key to maximizing a man's health? Without
question it is fighting inflammation. Yes, there are other worthy
candidates such as insulin, cortisol and estrogen. But in my opinion,
inflammation is the Great Destroyer.
And let me tell you why this subject is so important: if you decrease inflammation, you
will be surprised at how much better you feel, look and perform. More
importantly, you will attack at the source almost every major source of disease.
Most guys reaching my site are middle-aged and beyond. For us, mortality
has suddenly become reality. There can be some fear there, but, as I will show below,
inflammation attacks at the root virtually all of the major sources of death and
disease. If you get inflammation, you can live a life without fear with maximum
energy and productivity.
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Don't believe it? Then just look at this short list of nasty conditions that are
aided and abetted by inflammation:
1. Heart Disease. One of the root causes of cardiovascular disease
is inflammation. In fact, what is interesting is that some experts are
arguing that inflammation is THE root of heart disease. For example,
studies have shown that 1) hs-CRP (highly sensitive C-Reactive Protein) is the
strongest predictor of heart disease and 2) individuals with relatively low LDL
( < 120 mg/dl) but high hs-CRP had a high risk of cardiovascular risk. 
2. Erectile Dysfunction. This is such an important that I covered it
in another link on
Inflammation and Erections. Suffice it to say, though,
that some experts have argued that low-grade inflammation is actually the root
cause of most erectile dysfunction.
3. Cancer. TNF-alpha, the infamous inflammatory cytokine, can easily
become a cancer-causing machine: if you have enough of this, it
singlehandedly will help birth new cancers cells, aid in their survival and
promote their spread throughout the body. It also increases a host of other
pro-cancer cytokines.  This is why research is beginning to link inflammation
to colon , breast/lung  and prostate cancer . NOTE: For
additional information, see my link on How to Prevent Cancer.
4. Insulin Resistance. This plague of modern man and core symptom of
Syndrome has TNF-alpha as one of its primary root causes. 
5. Diabetes (Type II). Not too surprisingly, based on #4, C-Reactive
protein is a risk factor the development of diabetes. 
6. Multiple Sclerosis, Crohn's Disease and Rheumatoid Arthritis. TNF-alpha has
been associated with all of these nasty autoimmune disorders. 
This list could continue, but the point is that inflammation causes and
exacerbates all of the Big Three Killers of modern man: cardiovascular
disease, cancer and autoimmune disorders. If you can keep these three in check,
obviously your risk of death and debilitating disease will go down dramatically.
Ironically, almost everything we do in a modern, Western lifestyle actually promotes
inflammation, as I outline in my link on
How to Reduce Inflammation.
It would be difficult to live a more pro-inflammatory lifestyle than that
experienced by modern man.
Almost all of us are trained, from early childhood, in a lifestyle that
literally maximizes systemic inflammation and puts us at risk for a potentially
miserable life before a premature death, unless we get this monster under
2) Biochemical Pharmacology, 2006, 72:1605-1621, "Inflammation and cancer: How
hot is the link?"
3) Gastroenterology, 2010 Jun, 138(6):2101-2114, "Inflammation and colon cancer"
4) J Clin Invest, 2007 Dec 3, 117(12):3660–3663, "IL-6 involvement in epithelial
5) Nature, 2007 Apr 5, 446(7136):690-4, "Nuclear cytokine-activated IKKalpha
controls prostate cancer metastasis by repressing Maspin"
6) Journal of Clin Investigation, May 2 2005, 115(5), "Inflammation, stress, and
7) Diabetes Care, 2007 Oct, 30(10):2695-9, "Risk of type 2 diabetes attributable
to C-reactive protein and other risk factors"
8) Arthritis Rheum, 2001 Sep, 44(9):1977-83., "Demyelinating and neurologic
events reported in association with tumor necrosis factor alpha antagonism"