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3. ALA (Alpha Lipoic Acid). Many studies have shown that ALA can help with neuropathy, particularly the diabetic type. [4] ALA aids is a powerful antioxidant that aids in blood sugar control and mitochondrial protection. [5] Furthermore, anything that gets your blood sugar metabolism under better control will likely serve as a remedy as well.
4. Mitochondrial Protection. Because nerve cells are often so long, the mitochondria in the extremities are often very "old", i.e. several years in many cases. (Most cells replace their mitochondria every month or so.) Thus, researchers believe that protecting one's mitochondria may be critical to reduce the risk of neuropathy. [7] Of course, protecting one's mitochondria is a big subject, but a healthy diet, ALA, CoQ10 and exercise are some of the big keys. (Mitochondrial damage is also a culprit in accelerated andropause, i.e. the age-related loss in testosterone that most men experience.)
5. Fructose. Watch your consumption of fructose, as excess consumption is likely associated with neuropathy. [8] As I document in my link on Fructose Levels, you want to keep it to less than approximately 50 grams/day. Fructose supercharges mitochondria. This might sound good since mitochondria are the energy engines of your cells, but, unfortunately, they are also abundants sources of free radical and oxidation byproducts. (Yes, this is another mitochondrial-related link to neuropathy.)
6. Excitotoxins. Watch out for almost all whey powders and diet drinks along with any processed food that contains autolyzed yeast extract, hydrolyzed protein or monosodium glutamate. This is a big subject that I cover extensively on my site - do a search off my menu on "excitotoxins" - and likely leads to nerve dysfunction for many people. (Excitotoxins, if consumed in sufficient dosages, are neuron-killers. Some researchers have observed an Excitotoxin Syndrome that is related to overconsumption of these toxic molecules.
REFERENCES:
1) Am. J. Respir. Crit. Care Med., Jan 1999, 159(1):213-219, ""Peripheral Neuropathy in Sleep Apnea - A Tissue Marker of the Severity of Nocturnal Desaturation"
2) J Neurol Neurosurg Psychiatry, 2007 Mar, 78(3): 222, "Obstructive sleep apnoea: an underestimated cause of peripheral neuropathy"
3) http://www.ninds.nih.gov/disorders/restless_legs/ detail_restless_legs.htm
4) Neurologist, 2007 May, 13(3):164-7, "Alpha-lipoic acid may improve symptomatic diabetic polyneuropathy"
5) Exp Neurol, 2008 Dec;214(2):276-84, "Alpha-lipoic acid prevents mitochondrial damage and neurotoxicity in experimental chemotherapy neuropathy"
6) Pyschiatric Times, Colleen B. Litof and Dee Rapposelli , May 26, 2006, "Diet and Exercise May Reverse Damage of Impaired Glucose Tolerance Neuropathy", http://www.psychiatrictimes.com/display/article/10168/57201
7) http://www.sciencedaily.com/releases/2011/03/110303184111.htm
8) DIABETOLOGIA, 28(3):176-180, "Effects of a fructose-rich diet and the aldose reductase inhibitor, ONO-2235, on the development of diabetic neuropathy in streptozotocin-treated rats"
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