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Intense training has even found to effect the liver in healthy men! Researchers found abnormally elevated levels of many critical liver proteins.  Of course, that's not to say that intense excercise will kill you: but it does point out that intense excercise stresses the body in ways that we do not even understand yet. I also mention it because if you are on HRT, they should test liver function. If you get an abnormal reading, you may want to go easy on the workouts and get retested. hers recently found that, at least in women, moderate levels of exercise were helpful for long term memory and cognition, but strenous, long term exercise (such as marathons) were actually damaging to long term memory!  Of course, it could be some unknown factor in these women's lifestyle, but the odds are that elevated cortisol is wreaking its usual havoc on the brain in this case.
If you want to do intense workouts, I highly recommend SLOWLY building up. Personally, I have found that the key (for me) is to start with a moderate workout and then slowly increase the intensity as the weeks go by. This gradual pattern does not seem to disturb my testosterone levels or libido.
ATHLETES: Overtraining can seriously affect perfromance. Researchers have identified several short term key markers that result from overtraining, including "impaired anaerobic lactaid perforance and a reduced time to exhaustion".  The same study discusses many other soon-to-follow issues including problems with uric acid levels, ammonia, creatine kinase, free testosterone/cortisol, growth hormone and so on. More subjective issues include excessively sore muscles and sleep and mood disorders. Again, overtraining is real and leads to real physiological issues.
1) Jour Appl Physio, 2007, 103:693-99
2) JAMA. 2006;296:2307
3) British J Clin Pharm,2008, 65:253-259
4) Alzheimer's Association 2009 International Conference on Alzheimer's Disease, Vienna, Austria, July 11-16, 2009. Mary C. Tierney
5) Scandanavian J Med Sci Sports, 2008, 18:367-372
6) Immunology and Cell Biology (2000) 78, 502–509; "Overtraining effects on immunity and performance in athletes", Laurel T MacKinnon
7) Sports Medicine, Feb 1 2002, 32(2):95-102, "Diagnosis of Overtraining: What Tools do We Have?"
CAUTION: If you have a medical condition or are on any medications, please discuss any changes with your doctor first. Certain supplements, foods and even juices can alter absorption rates of certain medications for example. Play it safe.
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