Sometimes I think we make things too hard. Apples improve arterial
health. Grapes do the same and boost nitric oxide. So why not just combine
the two and try to get synergistic benefits?
That would seem to be the simple logic behind Vinitrox, one of the new and
popular supplements from Bio Serae that is used extensively in Europe. It simply
combines extracts of apple and grape into an optimized combination and - voila!
- you've got instant vasodilation.
In other words, this product will likely improve both blood pressure and
erectile dysfunction simply because of the power of its basic ingredients.
Consider just some of these benefits:
1. ET-1 and Superoxide Anion. Red wine polyphenols decrease a plasma chemical
called ET-1 and superoxide anion.  This will improve endothelial function.
2. eNOS. The key enzyme that boosts nitric oxide is eNOS and red wine
polyphenols were found to enhance its activity in an animals study. 
3. Adhesion Molecules. One apple flavonoid called phloretin suppresses the
endothelial adhesion molecules that cause arterial damage and arteriosclerosis.
4. Triglyericdes, Cholesterol and CRP. One animal study showed that apple juice
decreased all three of these major risk factors for heart and arterial disease.
5. Inflammatory Gene Expression. How about altering things on the genetic
level? That just what apple polyphenols do and it reduces inflammation -
always an erection helper. 
Anyway, we could go on and on here, but you get the point: both apples and
grapes are great for your cardiovascular system in general and will improve
endothelial function (nitric oxide and blood flow) significantly. And any apple
and grape extacts are likely to do the same.
All of this explains why Bio Serae's Vinitrox is growing in popularity in
Europe. Besides finding the right extract formulation, they also did extensive
experimentation to find the proportion that provides the greatest benefit as
I recently interviewed Christopher Pick, a naturopathic doctor and sports
trainer in the U.K. as to how he used Vinitrox in his practice. His
response was interesting, because he is one of the few physicians that is also
concerned with root causes and not just treating symptoms:
"Initially I would prefer to take the option of treating nutritional
deficiencies as a first step but I am afraid that where ED is concerned
guys want to tackle the erectile problem and little else! I have said
previously, I think, that ED is symptomatic of other serious diseases
such as heart disease. If they take this on board I can then deal with
the more wide ranging ramifications."
"The bottom line is that in most
cases I am happy to use Vinitrox as it is a natural product
that does work for the majority. I also usually insist that clients
take essential fatty acids & ionic minerals as part of the protocol. These
have a synergistic effect & are far more that the sum of the parts."
move to natural products is pretty strong in Europe as people become aware
of the problems with pharmaceuticals. With Vinitrox we are merely adding
to the nitric oxide pool rather
that interfering with an enzyme that breaks it down."
Dr. Pick sells his own formulation of Vinitrox, called Viextra, on his site
(which has sigificant information on erectile dysfunction).
For information, see his Viextra Fact Sheet.
1) Clin Sci (Lond), 2011 Apr, 120(8):321-33, "Red wine polyphenols
prevent endothelial dysfunction induced by endothelin-1 in rat aorta: role of
2) PLoS ONE, 4(5):e5557, "Red Wine Polyphenols Prevent Metabolic and
Cardiovascular Alterations Associated with Obesity in Zucker Fatty Rats (Fa/Fa)"
3) J. Nutr, Feb 1 2005, 135(2):172-178, "The Flavonoid Phloretin Suppresses
Stimulated Expression of Endothelial Adhesion Molecules and Reduces Activation
of Human Platelets"
4) Lipids in Health and Disease, 2009, 8:39, "Effects of apple juice on risk
factors of lipid profile, inflammation and coagulation, endothelial markers and
atherosclerotic lesions in gh cholesterolemic rabbits"
5) Molecular Nutrition & Food Research, Oct 2009, 53(10):1263–1280,
"Influence of apple polyphenols on inflammatory gene expression"