Weight Loss Cocktail
Every once in awhile you run across a study that is so remarkable that you are
left rubbing your eyes in disbelief.
Such is the case with one weight loss study in a 1999 journal called Medical
Hypotheses that gave a four-supplement cocktail to obese patients and watched
the rolls roll right off the participants. 
Those in the study lost an average of 3.3 total pounds per week and 5 pounds of
fat per week. Mama! Anyone who has dieted knows that normal weight
loss peaks at about 2 pounds per week. Yes, you may lose much more than
that in the first week due to water loss, but it quickly tapers off to about 2
pounds per week for those who really limit their caloric intake. So what makes
these results really astonishing is that these individuals not only sustained over 3 pounds
of weight loss per week but also lost more fat pounds than total pounds!
This implies a net gain of muscle mass as well.
NOTE: Talk to your doctor before taking any supplement, especially if you
are on medications or have medical conditions.
How does it all work? Well, synergism would be the operative word in "supplement
cocktails" such as these. Researchers will sometimes experiment with
different supplements that tackle a health problem through multiple pathways yielding
additive and sometimes even multiplicative effects. Four supplements were used
in such a manner in this study and below are the daily dosages:
8 grams Calcium Pyruvate
1.5 grams HCA
250 mg L-Carnitine
600 micrograms Chromium Picolinate
Calcium Pyruvate had in previous studies been shown to produce substantial
weight loss in overweight subjects even without reducing calories. 
Of course, this is amazing in and of itself as partipants lost
over 3 pounds total and about 5 pounds of fat in six weeks without the usual issues
of hunger and dieting. A pleasant concept for most trying to lose weight
is the idea of just doing a little daily exercising and taking 6 grams of
The results from this and other studies were so promising that one prominent
researcher in the field decided to take Calcium Pyruvate and couple it with some
other studies to hopefully get a fat loss boost. So what are these supplements
and what do they do?
CAUTION: Calcium Pyruvate has - shock! - a lot of calcium and this
is risky for us guys. (Elevated calcium consumption is linked to prostate
cancer in males.) For this reason, I do not recommend this supplement
protocol for more than a few weeks.
Chromium Picolinate, of
course, a common supplement that delivers this all-important mineral to our
insulin and glucose metabolism. Of course, insulin resitance is the
arch-nemesis of weight loss and is very often a problem in those with too many
extra pounds. Furthermore, the typical modern diet not only delivers too little
chromium but actually depletes it from the body. 
also improves glucose
Calcium Pyruvate and L-Carnitine, on the other hand, work by increasing fatty
acid oxidation, i.e. fuel burning.
literally transports your fats
into mitochondria to get churned and burned. HCA helps this same process
by shifting your body's balance from carbohydrate to fat burning as well.
And both Calcium Pyruvate and L-Carnitine have been associated with an increased
base metabolic rate as well, i.e. more calories are burned by one's system
throughout the day.  The bottom line is that all of these appear to work together
to accelerate weight loss in a
semi-dramatic fashion, at least for those who are significantly overweight.
Med Hypotheses, 1999 May, 52(5):407-16, "Pyruvate and hydroxycitrate/carnitine
may synergize to promote reverse electron transport in hepatocyte mitochondria,
effectively 'uncoupling' the oxidation of fatty acids"
2) Nutrition Research Reviews (2003), 16: 267-275, "Chromium and insulin
3) Fitoterapia, 2003 Apr, 74(3):267-73, "Garcinia cambogia extract on serum
leptin and insulin in mice"
4) J Nutr, 2000 Dec, 130(12):2990-5, "Chronic (-)-hydroxycitrate administration
spares carbohydrate utilization and promotes lipid oxidation during exercise in
5) Metabolism, 1986 Feb, 35(2):182-6, "Inhibition of lipid accumulation and
enhancement of energy expenditure by the addition of pyruvate and
dihydroxyacetone to a rat diet"
6) J. Nutr, Aug 1 1996, 126(8):1937-1950, "Atlantic Salmon (Salmo salar) Fed
L-Carnitine Exhibit Altered Intermediary Metabolism and Reduced Tissue Lipid,
but No Change in Growth Rate"
7) Medicine and Science in Sport and Exercise, 1998, 15(5):337-340, "Effects of
Exogenous Pyruvate on Body Composition and Energy Levels"