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Rapid weight loss also negatively alters most of the key appetite hormones as I outline in my link on Hormones and Your Appetite. This requires crash dieters to display almost superhuman will power and can easily lead to rebound eating.
By the way, one area of anti-aging research is caloric restriction. Reducting calories by about 30 percent extends maximum lifespan in mice and many animals. (It doesn't seem to work as well in humans.) How does caloric restriction do its magic in animals? Researchers believe it may work in mice by "feminizing" them. In fact, here is the title of one article: "Short-Term Calorie Restriction in Male Mice Feminizes Gene Expression and Alters Key Regulators of Conserved Aging Regulatory Pathways."
Again, I ask if crash dieting really how you want to lose weight?
CAUTION: Rapid weight loss may be desireable for some very obese individuals: discuss with your doctor.
REFERENCES:
1) Metabolism, 1986 Apr, 35(4):289-91, "Decrease in resting metabolic rate during rapid weight loss is reversed by low dose thyroid hormone treatment"
2) The Journal of Clinical Endocrinology & Metabolism, Jun 1 1989, 68(6):1013-1018, "Fasting Alters Pulsatile and Rhythmic Cortisol Release in Normal Man"
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