Why Doesn't Viagra Work?
Viagra is a miracle pill, right? Actually, it is suprising how often Viagra and
the other PDE5 Inhibitors do not work for men with erectile dysfunction. Many
guys are left asking, "Why doesn't Viagra work for me?"
Just how common is this issue? PDE5 Inhibitors, such
Viagra, Levitra and/or Cialis, are unsuccessful in about a fourth of all men
with erectile dysfunction. Furthermore,
in certain at-risk subpopulations, there is an even greater chance for failure. For
example, only about half of all diabetics are able to use one of these
medications successfully. 
So why, pray tell, would a powerful drug such as Viagra and Cialis, not work?
Well, the research has uncovered some interesting and not-necessarily-obvious
reasons for this stressful phenomenon:
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1. Resistance. You can actually become resistant to PDE5 Inhibitors over
time.  Of course, that means you must up the dosage to get the same effect
and this is problematic because Viagra, Cialis and Levitra have so many side
effects. See my link on Viagra and Cialis Resistance
for more details.
(In addition, you may want to read on
The Side Effects of PDE5 Inhibitors
Dangers of Cialis for more information.)
2. Low Testosterone/Venous Leakage. Some guys actually have atrophy of various
peniles tissues, including nerve, connective and muscular. This most often
occurs in a low testosterone environment and I have covered in detail in my link
on Venous Leakage. This can usually be
greatly improved through
3. Lack of Baseline Nitric Oxide. One major reason, and I cover
solutions for this condition in my link on Viagra Failure, is the lack of
baseline nitric oxide. Many men with endothelial dysfunction simply do not
supply enough raw materials into this biochemical pathway to make up for the
age-related loss in this compound, a term called "nitric oxide insufficiency."
You can't "squeeze blood out of a turnip" as they say.
NOTE: One way to solve this lack of baseline nitric oxide is through the consumption of high nitrate foods. See my
links on Beetroot Juice
and A Review of Beet the Odds
for more information.
4. Psychology (Fear, Anxiety, etc.). Some guys have normal erectile
strength, yet have erectile dysfunction during intercourse. This is termed
psychogenic (psychological) erectile dysfunction and can be very difficult to
overcome. Interestingly enough, Viagra and other PDE5 Inhibitors can be
used as partial or even complete treatment as I document in my link on
Psychogenic Erectile Dysfunction. However, for those who experience
failure, obviosly no amount of these medications will help.
5. Major Medical.
Certain major medical conditions such as prostate procedures, pelvic surgeries,
back injuries and advanced cardiovascular disease can negate all normal
drug-related attempts to acheive an erection.
1) Current Vascular Pharmacology, 2006, 4:89-93, "The Management of
Phosphodiesterase-5 (PDE5) Inhibitor Failure"
2) J Urol, 2001 Sep, 166(3):927-31, "Long-term efficacy of sildenafil and