Thank you all for your suggestions. Yes, the symptoms are physically keeping me up.
Very interesting about the norepinephrine. I haven't tried l-theanine and glycine at night.
Do you take them together or separately? I haven't had a lot of success with the Gaba.
How much do you recommend? I think I have brain inflammation causing the symptoms and they are only made worse with lack of sleep. I took two Aspirins and that helped with the inflammation and lessening symptoms, but after four hours symptoms came back. I was taking a low dose of doxeypin (6 - 8 mg), on and off, which helped at first, but it stopped working, so I quit using it. Meditation and mantras help.
I'm not planning TRT therapy. I'll look into CBD. I hear good things as well. Thank you.
Sorry for the delay!
I'd try taking them separately at first, then together. I'd start with your lowest dose of 1000 mg of glycine, then add 1000 mg the next night and another 1000 the following, but wouldn't go past this although many people do. Doxepin stops working for lots of people. It's an antihistamine tricylclic, so you might look into the doxylamine succinate which you can get over the counter, but I wouldn't take it more than a few times per week given that it has a pretty long half life (10-12 hours, like doxepin). My fancy doc (Dr Mariano) prescribed guanfacine, a blood pressure med which works through lowering norepinephrine, off label for sleep, with the assumption that my problem is high norepinephrine/inflammation. However, for me, despite it knocking out lots of people who take it during the day for blood pressure (which is why it's not usually prescribed for BP, now more for autism and off label for sleep), I didn't notice much if anything even after doubling the dose with his supervision, meaning my issues may not be norepinephrine related (which was also backed up through other testing you could get, called fractionated catecholamine testing, but doesn't test actual neurotransmitter levels of norepinephrine, epinephrine, and dopamine, only levels in the blood, and those aren't necessarily the same).
According to him (and so far given my research he's right), inflammation and norepinephrine are in a positive feedback loop, meaning each increase the other to some degree, and his great advice is that if my illness is inflammation-related, the goal is to decrease the size of the feedback loop through multiple supplements that lower inflammation, such as fish oil/krill oil, astaxanthin, vitamin A, B12, D, K2, E, and a few others. So if you're suspecting inflammation -- and it's promising that you're onto something if you feel better with aspirin, but it could possibly be something else -- you might give these a shot. So far the ones listed haven't seen to have made a noticeable difference, but his two other recommendations, iodine and quercetin, have helped pretty well. The latter is known to reduce inflammation through reducing mast cell release.
Also, if you suspect brain inflammation, you gotta make sure your gut health is in line, as the brain and gut (strangely) work together, with "leaky gut" leading to "leaky brain" (i.e., perfused blood-brain barrier, causing inflammation). Chris Kresser has the amazing claim, backed by research, that lots of depression is likely leaky brain related, related to poor gut health. Probiotics are a great place to start (get a good quality one online that has 40-50 billion CFU). I recently got into kombucha, rich in probiotics, and love the stuff for the taste.