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Author Topic: Highly considering HCG monotherapy. Does anyone have experience or feedback?  (Read 2523 times)

bbnoob25

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Hi All,

Straight to the point:
I am highly considering HCG monotherapy (with Anastrozole if needed for estradiol control) to combat opioid induced low-t at the age of 28 with fertility as a major concern. Can anyone share his/her experience with HCG monotherapy, or a friends HCG treatment, or really any HCG therapy for that matter, including the pros and cons of the medication? I am most concerned with adverse side effects, so please include those in your description if possible.

A little background:
I have made another post regarding my low-t, which I used Clomid to treat (see link below) and while that seemed to have worked, I began to have visual disturbances, even at a very low dose of 12.5mg EOD, so I stopped it immediately. I am very scared of the visual side effects of any medication now, so it seems Nolvadex is also out of the question, which leaves HCG to be one of the few remaining treatments to ensure fertility is maintained.

Previous post: http://www.peaktestosterone.com/forum/index.php?topic=11517.0


Thanks!
« Last Edit: December 18, 2016, 07:12:07 pm by bbnoob25 »
Current protocol
Test cyp = 80mg E3.5D
hCG = 350iu 3x per week
Anastrozole = .25mg E3.5D

tlatoani

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I am in a similar position as you, though younger 22, but I would be careful about HCG as there are studies that proved and found Prions in HCG, which came from urine.

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Hydranted

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No personal experience with hCG monotherapy, but the success stories seem to be too infrequent for me to really think that it's an effective treatment.  Just seems like an outdated way to treat hypogonadism in my opinion.

Sure fertility is preserved, but we now know that this can be achieved by using lower doses of hCG along with testosterone. 

Many men on hCG monotherapy seem to have an extremely difficult time with their estradiol.  And even when it's well controlled, they often don't achieve much in the way of symptom relief.  There are definitely men out there doing well on hCG monotherapy, but their numbers are dwarfed by those who just can't seem to get right with the drug by itself.


ri.beira

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I am in a similar position as you, though younger 22, but I would be careful about HCG as there are studies that proved and found Prions in HCG, which came from urine.

https://wwwnc.cdc.gov/eid/article/18/1/11-0589_article

"We tested raw urine and 100-fold concentrated and dialyzed urine and assessed the sensitivity of the bioassay along with the effect of concentration and dialysis on prion infectivity. Intracerebral inoculation of transgenic mice with urine from 3 sCJDMM1 patients failed to demonstrate prion disease transmission, indicating that prion infectivity in urine from sCJDMM1 patients is either not present or is <0.38 infectious units/mL."

Do you have any studies that prove that hCG is infectious?

There's always rhCG as an alternative.

tlatoani

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I am in a similar position as you, though younger 22, but I would be careful about HCG as there are studies that proved and found Prions in HCG, which came from urine.

https://wwwnc.cdc.gov/eid/article/18/1/11-0589_article

"We tested raw urine and 100-fold concentrated and dialyzed urine and assessed the sensitivity of the bioassay along with the effect of concentration and dialysis on prion infectivity. Intracerebral inoculation of transgenic mice with urine from 3 sCJDMM1 patients failed to demonstrate prion disease transmission, indicating that prion infectivity in urine from sCJDMM1 patients is either not present or is <0.38 infectious units/mL."

Do you have any studies that prove that hCG is infectious?

There's always rhCG as an alternative.

yeah this one, quite shocking :

https://www.ncbi.nlm.nih.gov/pubmed/21448279


what is rHCG, is it also gained from urine of people?

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Osprey

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I am in a similar position as you, though younger 22, but I would be careful about HCG as there are studies that proved and found Prions in HCG, which came from urine.

https://wwwnc.cdc.gov/eid/article/18/1/11-0589_article

"We tested raw urine and 100-fold concentrated and dialyzed urine and assessed the sensitivity of the bioassay along with the effect of concentration and dialysis on prion infectivity. Intracerebral inoculation of transgenic mice with urine from 3 sCJDMM1 patients failed to demonstrate prion disease transmission, indicating that prion infectivity in urine from sCJDMM1 patients is either not present or is <0.38 infectious units/mL."

Do you have any studies that prove that hCG is infectious?

There's always rhCG as an alternative.

yeah this one, quite shocking :

https://www.ncbi.nlm.nih.gov/pubmed/21448279


what is rHCG, is it also gained from urine of people?

That study does not show that urine derived hcg is infectious, it just shows that prion proteins may be present. Still a little disconcerting though. You would think that hcg has been used for long enough for there to be some epidemiological evidence indicating an actual risk of infection.

 

tlatoani

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I am in a similar position as you, though younger 22, but I would be careful about HCG as there are studies that proved and found Prions in HCG, which came from urine.

https://wwwnc.cdc.gov/eid/article/18/1/11-0589_article

"We tested raw urine and 100-fold concentrated and dialyzed urine and assessed the sensitivity of the bioassay along with the effect of concentration and dialysis on prion infectivity. Intracerebral inoculation of transgenic mice with urine from 3 sCJDMM1 patients failed to demonstrate prion disease transmission, indicating that prion infectivity in urine from sCJDMM1 patients is either not present or is <0.38 infectious units/mL."

Do you have any studies that prove that hCG is infectious?

There's always rhCG as an alternative.

yeah this one, quite shocking :

https://www.ncbi.nlm.nih.gov/pubmed/21448279


what is rHCG, is it also gained from urine of people?

That study does not show that urine derived hcg is infectious, it just shows that prion proteins may be present. Still a little disconcerting though. You would think that hcg has been used for long enough for there to be some epidemiological evidence indicating an actual risk of infection.


the researchers of the study concluded however that this fact is so significant that the "The risks of urine-derived fertility products could now outweigh their benefits" !,that should mean something - and that " intramuscular injection is a relatively efficient route of transmission of human prion disease"
and as every urine donor is NOT checked thoroughly for prion diseases there is definitly a small percentage of people that will get infected with prions,especially if it is used for years, decades...

also, just because there arent any studies that made a connection between prion disease and HCG it doesnt mean that HCG could not have been the cause-its all a matter of time, there are so many things happening in our bodies that will still be discovered -doesnt mean they re not happening.
And most prion disease really fuck someone up big time so definilty worth it to look into this more.
« Last Edit: December 19, 2016, 07:24:10 am by tlatoani »

Osprey

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the researchers of the study concluded however that this fact is so significant that the "The risks of urine-derived fertility products could now outweigh their benefits" !,

Nothing in that paper supports that conclusion. To come to that conclusion they would need some actual cases of disease that were proven to be caused by injecting HCG.

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PeakT

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So, if I am understanding right, it has "misfolded proteins" in it and the concern is that it could cause this:

https://en.wikipedia.org/wiki/Creutzfeldt%E2%80%93Jakob_disease

So the question I guess is whether or not these misfolded proteins can actually be incorporated intracellularly and cause damage and so far there is no sign of that?  Am I reading that right guys?
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ri.beira

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So, if I am understanding right, it has "misfolded proteins" in it and the concern is that it could cause this:

https://en.wikipedia.org/wiki/Creutzfeldt%E2%80%93Jakob_disease

So the question I guess is whether or not these misfolded proteins can actually be incorporated intracellularly and cause damage and so far there is no sign of that?  Am I reading that right guys?

Yes, I think the researchers found these "misfolded proteins".

Here is a comment on that study:

http://journals.plos.org/plosone/article/comment?id=10.1371/annotation/a7997963-87c7-48bb-be3a-cb0d3ecf11fe

They come to this conclusion:
"The authors suggest that ‘the risks of urine-derived fertility products could now outweigh their benefits.’ This theoretical risk has not been borne out in reality and in our opinion, is therefore unjustified."

bbnoob25

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Guys, is there a single case of someone  contracting any type of disease of even an illness from HCG? Why do I feel like this is up there with coffee causing cancer. HCG was my last hope, so I'm obviously rationalizing here, but still. It seems far fetched that the FDA would allow this to happen in the same era they ban anti bacterial soap.
Current protocol
Test cyp = 80mg E3.5D
hCG = 350iu 3x per week
Anastrozole = .25mg E3.5D

PeakT

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Guys, is there a single case of someone  contracting any type of disease of even an illness from HCG? Why do I feel like this is up there with coffee causing cancer. HCG was my last hope, so I'm obviously rationalizing here, but still. It seems far fetched that the FDA would allow this to happen in the same era they ban anti bacterial soap.

Not that I know of.  Of course it's always wise to know your compounder.
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And check out my New Peak Testosterone Program: http://www.peaktestosterone.com/peak_testosterone_program.aspx
If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements.  And low testosterone is a medical condition.

bbnoob25

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Speak of the devil and he shall appear. New blood test has been confirmed 100% accurate to test for prion disease.

"Blood Tests for Prion Disease
Two studies describe methods for detecting these misfolded proteins in human blood samples."
http://www.the-scientist.com/?articles.view/articleNo/47841/title/Blood-Tests-for-Prion-Disease/
Current protocol
Test cyp = 80mg E3.5D
hCG = 350iu 3x per week
Anastrozole = .25mg E3.5D

PeakT

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Speak of the devil and he shall appear. New blood test has been confirmed 100% accurate to test for prion disease.

"Blood Tests for Prion Disease
Two studies describe methods for detecting these misfolded proteins in human blood samples."
http://www.the-scientist.com/?articles.view/articleNo/47841/title/Blood-Tests-for-Prion-Disease/

"Thousands of Europeans may be asymptomatic carriers of variant Creutzfeldt-Jakob disease (vCJD), a fatal prion disease that is the human variant of Mad Cow disease. But now, two studies published December 21 in Science Translational Medicine describe new methods for detecting even latent vCJD, which could make blood transfusions safer and help early detection and treatment of the disease.

The blood tests accurately diagnosed 32 patients between the two studies, distinguishing those with the disease from 391 healthy controls. In both cases, the tests were 100 percent sensitive and 100 percent specific and, in one of the studies, the test managed to identify vCJD prion particles in a blood donation more than a year before the onset of symptoms—a first for prion disease detection.

“There is new technology to go forward, and it looks promising,” Jonathan Wadsworth, a prion disease expert at University College London, who was not involved in the study, told Science. “These are definitely very welcome papers.”"
THE MOST COMPREHENSIVE BOOK ON TRT/TESTOSTERONE:
https://www.amazon.com/Natural-Versus-Testosterone-Therapy-Myer/dp/1523210532/ref=sr_1_1?ie=UTF8&qid=1499116128&sr=8-1&keywords=natural+versus+testosterone+therapy
And check out my New Peak Testosterone Program: http://www.peaktestosterone.com/peak_testosterone_program.aspx
If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements.  And low testosterone is a medical condition.

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