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Author Topic: Estradiol issues  (Read 946 times)

Smokdu

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Estradiol issues
« on: January 06, 2017, 07:35:05 am »
So I've been on TRT for about 10 weeks now. My baseline T level was 338 with "Ultrasensitive E2 level" of 18 (<29). After being on Anastrazole  (.25mg x 2 weekly) my follow-up labs showed my TT @ 989 & E2 @ 13.

I initially got on TRT due to low libido, lousy EQ, night sweats, mental fog, depression, and gaining fat/losing muscle. But mostly for the libido & erection issues really.

So far, I've noticed little improvement in these two issues. Everything else has improved greatly, and aside from a lousy sex life, I feel pretty good.

After much reading, I thought perhaps my E2 was too LOW, so I quit the AI two weeks ago. I am now having back/joint pain, trouble sleeping, a dull headache (last 4 days) and no real change in libido. EQ seems to have improved, but not necessarily frequency. I've also noticed the last two days it's been harder to breathe, like I have a chest cold, or allergies or something.  Does this likely mean my E2 levels are too high now? Could they really shoot up that fast? Should I start back on the AI? I tried to stop the AI a few weeks back, but had joint pain and shitty sleep almost immediately after stopping, so I started back on it again. I thought maybe it was just coincidence, so I'd try it again.

I just started working with this doctor and I don't want her to think "Oh great, it's one of those guys", you know, self-diagnosing and all that. I just wanted to try to tweak things myself to see if I could solve my own problems.

As always, any suggestions are appreciated.
43 y/o
5'8", 173lbs
Around 13% BF and goin⤵
Started TRT 10/10/16 with a baseline of 338,
Last labs at 989. Still working out the bugs

Sean Mosher

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Re: Estradiol issues
« Reply #1 on: January 06, 2017, 10:19:10 am »
E2 of 13 is definitely on the lower side.
May be something to discuss with your doc (possibly you only need 0.25mg once a week or even a smaller dosage?)....

I don't think your E2 would rebound that quickly.
Usually 4-6 weeks.
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Re: Estradiol issues
« Reply #1 on: January 06, 2017, 10:19:10 am »

Smokdu

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Re: Estradiol issues
« Reply #2 on: January 06, 2017, 10:30:31 am »
Hmmm...Maybe it's an effect of coming off the anastrazole? Whatever it is, it's real. I feel like shit again.

I will definitely discuss it with my doctor. I think I'll give it another week before starting back on the AI.
43 y/o
5'8", 173lbs
Around 13% BF and goin⤵
Started TRT 10/10/16 with a baseline of 338,
Last labs at 989. Still working out the bugs

PeakT

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Re: Estradiol issues
« Reply #3 on: January 06, 2017, 05:37:51 pm »
Hmmm...Maybe it's an effect of coming off the anastrazole? Whatever it is, it's real. I feel like shit again.

I will definitely discuss it with my doctor. I think I'll give it another week before starting back on the AI.

Yeah, some guys are sensitive to Arimidex.  Remember you can get it compounded to any dosage you want just about.  You don't have to use the standard pills which are hard to cut accurately, etc.
If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements. Yes, low T and E.D. are usually medical conditions.  There are potential risk with HRT:  http://www.peaktestosterone.com/testosterone_risks.aspx.
My Health History: http://www.peaktestosterone.com/My_Health_Story.aspx.
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Smokdu

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Re: Estradiol issues
« Reply #4 on: January 08, 2017, 12:06:10 am »
@PeakT- everything I get is compounded; the AI as well as my pellets.

It's been two full weeks now and I'm still having pain in my lower back which showed up right after I quit the AI. I'm going to try to make it til my next appointment on the 30th, and if I don't feel some improvement in libido (and aches) I'll start taking half the dose of AI. If I have low libido either way, I'd rather do it without the aches and pains.
43 y/o
5'8", 173lbs
Around 13% BF and goin⤵
Started TRT 10/10/16 with a baseline of 338,
Last labs at 989. Still working out the bugs

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Re: Estradiol issues
« Reply #4 on: January 08, 2017, 12:06:10 am »

PLEASE SUPPORT THE SITE AND GIVE AN AMAZON REVIEW IF POSSIBLE:


PeakT

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Re: Estradiol issues
« Reply #5 on: January 08, 2017, 08:43:52 am »
@PeakT- everything I get is compounded; the AI as well as my pellets.

It's been two full weeks now and I'm still having pain in my lower back which showed up right after I quit the AI. I'm going to try to make it til my next appointment on the 30th, and if I don't feel some improvement in libido (and aches) I'll start taking half the dose of AI. If I have low libido either way, I'd rather do it without the aches and pains.

Got it.  Sorry but many men don't think of that option.
If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements. Yes, low T and E.D. are usually medical conditions.  There are potential risk with HRT:  http://www.peaktestosterone.com/testosterone_risks.aspx.
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Smokdu

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Re: Estradiol issues
« Reply #6 on: January 10, 2017, 10:03:15 am »
So I quit taking the weekly .5mg of Anastrazole 2 and a half weeks ago in the hopes that my low E2 level was the reason for my low libido. Since I stopped the AI, my lower back and knees have been killing me, which of course affects my sleep, which affects my energy level, workouts, productivity,  etc. Of a bigger concern however, was the fact that I haven't had morning wood for 4 consecutive mornings. Before I quit the AI, when my E2 level was @ 13, I had GREAT morning wood EVERY morning.
This morning, I noticed my stomach was "puffy". I have been working on my 6-pack, and it was noticeably missing. So I jumped on the scale and I was 5 pounds heavier than a week ago. I figure it must be water retention.
That being said, I threw in the towel, and took .125mg (half of a half dose) of the AI. Strange that although my E2 level has no doubt risen over the 2.5 weeks to supposed "normal levels", I have felt worse and worse.
So what does a man do, when you only feel decent at "dangerously low" E2 levels?
43 y/o
5'8", 173lbs
Around 13% BF and goin⤵
Started TRT 10/10/16 with a baseline of 338,
Last labs at 989. Still working out the bugs

PeakT

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Re: Estradiol issues
« Reply #7 on: January 10, 2017, 02:21:10 pm »
So what does a man do, when you only feel decent at "dangerously low" E2 levels?

Don't know.  You've got to talk to a smart doc about that one.  My only comment is that you should be able to get an erection even if your estradiol is 20-25 pg/ml - something does not seem right there.
If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements. Yes, low T and E.D. are usually medical conditions.  There are potential risk with HRT:  http://www.peaktestosterone.com/testosterone_risks.aspx.
My Health History: http://www.peaktestosterone.com/My_Health_Story.aspx.
And check out my new Peak Testosterone Program on the right side of my home page: http://www.peaktestosterone.com.

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Re: Estradiol issues
« Reply #7 on: January 10, 2017, 02:21:10 pm »


Smokdu

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Re: Estradiol issues
« Reply #8 on: January 10, 2017, 07:13:57 pm »
It's not that I couldn't get it up, it was a sudden lack of NPT & morning wood that had me concerned. I'll see if things improve now that I'm back on super low-dose AI.
43 y/o
5'8", 173lbs
Around 13% BF and goin⤵
Started TRT 10/10/16 with a baseline of 338,
Last labs at 989. Still working out the bugs

PeakT

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Re: Estradiol issues
« Reply #9 on: January 10, 2017, 08:43:51 pm »
It's not that I couldn't get it up, it was a sudden lack of NPT & morning wood that had me concerned. I'll see if things improve now that I'm back on super low-dose AI.

OK sorry if I overstated. But the same principle still applies in my opinion that something just doesn't seem right.  One Thing that I wonder about is if the old 15 pg/ml corresponds to a lower value with lc-msms. Dont know
If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements. Yes, low T and E.D. are usually medical conditions.  There are potential risk with HRT:  http://www.peaktestosterone.com/testosterone_risks.aspx.
My Health History: http://www.peaktestosterone.com/My_Health_Story.aspx.
And check out my new Peak Testosterone Program on the right side of my home page: http://www.peaktestosterone.com.

Smokdu

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Re: Estradiol issues
« Reply #10 on: January 10, 2017, 09:07:46 pm »
@PeakT- No worries my friend, no apologies necessary. I agree, something is not right.

Like I said, E2 started at 18, dropped to 13 after starting TRT & AI. NPT & morning wood came back instantly, and only stopped when I quit the AI for 2.5weeks. I guess I will know if it's my E2 causing the issues if that all comes back.

I'm keeping a log of everything to present to my doc so she can see what I've tried, so we're not chasing our tails.
43 y/o
5'8", 173lbs
Around 13% BF and goin⤵
Started TRT 10/10/16 with a baseline of 338,
Last labs at 989. Still working out the bugs

PeakT

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Re: Estradiol issues
« Reply #11 on: January 11, 2017, 01:53:34 pm »
@PeakT- No worries my friend, no apologies necessary. I agree, something is not right.

Like I said, E2 started at 18, dropped to 13 after starting TRT & AI. NPT & morning wood came back instantly, and only stopped when I quit the AI for 2.5weeks. I guess I will know if it's my E2 causing the issues if that all comes back.

I'm keeping a log of everything to present to my doc so she can see what I've tried, so we're not chasing our tails.

Yeah, but a comment:  If I understand right, you are saying that at 18, things sucked and at 13 everything was great.  Not that could be the underlying factor, but I find it hard to believe that five points in e2 would make that much difference.  I would dig and think if there was any other change that could explain that.  Again, not saying your wrong - just want you to consider things outside of T/E2.
If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements. Yes, low T and E.D. are usually medical conditions.  There are potential risk with HRT:  http://www.peaktestosterone.com/testosterone_risks.aspx.
My Health History: http://www.peaktestosterone.com/My_Health_Story.aspx.
And check out my new Peak Testosterone Program on the right side of my home page: http://www.peaktestosterone.com.

Smokdu

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Re: Estradiol issues
« Reply #12 on: January 11, 2017, 10:02:52 pm »
No what I'm saying is as soon as I started TRT, NPT & morning wood came back. My baseline E2 level at that time was 18. By the time I retested 6 weeks later I was at 13. I felt the same, but was still struggling with lousy EQ and low libido, just like when I was at 18. It was when I quit taking Anastrazole for 2.5 weeks, theoretically raising E2 somewhat, that the NPT & morning wood disappeared. Sorry if I didn't explain it very well.

As an update, I started taking the AI again yesterday morning,  and woke up today with good wood. First time in 4 days. Now I do not really understand the science of this stuff, and have no preconceived ideas of how fast or slow it works. I just report the facts. I know my Base Metabolic Rate is 1800 calories a day, so things usually kick in quite fast for me.
43 y/o
5'8", 173lbs
Around 13% BF and goin⤵
Started TRT 10/10/16 with a baseline of 338,
Last labs at 989. Still working out the bugs

Balderdasher

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Re: Estradiol issues
« Reply #13 on: January 12, 2017, 07:04:29 am »
No what I'm saying is as soon as I started TRT, NPT & morning wood came back. My baseline E2 level at that time was 18. By the time I retested 6 weeks later I was at 13. I felt the same, but was still struggling with lousy EQ and low libido, just like when I was at 18. It was when I quit taking Anastrazole for 2.5 weeks, theoretically raising E2 somewhat, that the NPT & morning wood disappeared. Sorry if I didn't explain it very well.

As an update, I started taking the AI again yesterday morning,  and woke up today with good wood. First time in 4 days. Now I do not really understand the science of this stuff, and have no preconceived ideas of how fast or slow it works. I just report the facts. I know my Base Metabolic Rate is 1800 calories a day, so things usually kick in quite fast for me.

Did you have any other labs pulled after you went on TRT?  Might be helpful to check those out.

It can definitely take awhile to get a good protocol figured out, so don't give up hope.  Hard for anyone to say for sure what the next move should be without seeing updated labs with every protocol change, keeping in mind that it can take weeks for an adjustment to take effect.
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Smokdu

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Re: Estradiol issues
« Reply #14 on: January 12, 2017, 09:11:56 am »
@Balderdasher, yes I did have follow-up labs done, but I won't see my doc until the 30th to see all the numbers. She was nice enough to give me my TT, E2, & SHBG while at my wife's appointment.
43 y/o
5'8", 173lbs
Around 13% BF and goin⤵
Started TRT 10/10/16 with a baseline of 338,
Last labs at 989. Still working out the bugs

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Re: Estradiol issues
« Reply #14 on: January 12, 2017, 09:11:56 am »