Quantcast

Author Topic: Calcium D-Glucarate Can Really Increase Libido  (Read 6144 times)

Dr. John Crisler

  • Full Member
  • ***
  • Posts: 104
    • View Profile
Calcium D-Glucarate Can Really Increase Libido
« on: January 09, 2017, 08:50:45 pm »
I've seen--and felt--500mg twice per day do wild things for guys' libidos.

Estrogen builds up because (1) too much conversion from T (2) not enough metabolization and break down (3) both.

Ca-d-G helps with the breakdown.

For those on Clomid, it's many times helpful.
« Last Edit: January 10, 2017, 05:41:43 pm by PeakT »
Physician in Age Management Medicine private practice. www.DrJohnCrisler.com

NOTE: Comments on this forum are NOT medical advice and are no substitute for individualized patient care. Please consult your personal physician prior to initiating or changing ANY treatment regimen.

Kierkegaard

  • Moderator
  • Hero Member
  • *****
  • Posts: 3384
  • Hormone Shrink
    • View Profile
Re: Calcium D-Glucarate Can Really Increase Libido
« Reply #1 on: January 09, 2017, 08:59:58 pm »
I've seen--and felt--500mg twice per day do wild things for guys' libidos.

Estrogen builds up because (1) too much conversion from T (2) not enough metabolization and break down (3) both.

Ca-d-G helps with the breakdown.

For those on Clomid, it's many times helpful.

Dr Crisler,

Without having to get too nerdy (unless you want to, by all means), how does CDG compare to DIM in terms of breakdown -- i.e., how does it work in contrast to DIM, which works its magic through increasing the 2- (but also unfortunately 4-, meaning carcinogenic) hydroxyestrone pathway? 

Do you prefer one over the other?  How much of a drop in E2 do you tend to see for the 500mg twice per day dose?

Thanks!
« Last Edit: January 10, 2017, 05:41:53 pm by PeakT »
"The same thing that makes you live can kill you in the end." -- Neil Young

March 2014: Dx low T (158ng/dl)
September 2015: Dx hypothyroidism, other adrenal hypofunction/low cortisol
Treatment: 30-35 mg cypionate subq E3D, 50 mcg levothyroxine QD; adaptogens
Supplements: fish oil, vitamin D3, magnesium, copper (low in serum), DIM, coq10, B vitamins (including hydroxyb12), probiotic, astaxanthin, iodine
Depression and anxiety guide: http://www.peaktestosterone.com/Help_Anxiety_Depression.aspx

Peak Testosterone Forum

Re: Calcium D-Glucarate Can Really Increase Libido
« Reply #1 on: January 09, 2017, 08:59:58 pm »

vvs1

  • Sr. Member
  • ****
  • Posts: 262
    • View Profile
Re: Calcium D-Glucarate Can Really Increase Libido
« Reply #2 on: January 09, 2017, 09:04:03 pm »
I take CDG on occasion since my SHBG is higher. It went from 35 to 55 in a couple years with no TRT either time.

If my serum estradiol is normal, and T3, T4 are on the lower end of normal, what causes my high SHBG?

The only other causes ive read are dehydration, starvation/malnutrition, which aren't the case.
« Last Edit: January 10, 2017, 05:42:02 pm by PeakT »

Kierkegaard

  • Moderator
  • Hero Member
  • *****
  • Posts: 3384
  • Hormone Shrink
    • View Profile
Re: Calcium D-Glucarate Can Really Increase Libido
« Reply #3 on: January 09, 2017, 09:10:09 pm »
I take CDG on occasion since my SHBG is higher. It went from 35 to 55 in a couple years with no TRT either time.

If my serum estradiol is normal, and T3, T4 are on the lower end of normal, what causes my high SHBG?

The only other causes ive read are dehydration, starvation/malnutrition, which aren't the case.

Peak has a great list of possibilities here: http://www.peaktestosterone.com/High_SHBG.aspx
« Last Edit: January 10, 2017, 05:42:11 pm by PeakT »
"The same thing that makes you live can kill you in the end." -- Neil Young

March 2014: Dx low T (158ng/dl)
September 2015: Dx hypothyroidism, other adrenal hypofunction/low cortisol
Treatment: 30-35 mg cypionate subq E3D, 50 mcg levothyroxine QD; adaptogens
Supplements: fish oil, vitamin D3, magnesium, copper (low in serum), DIM, coq10, B vitamins (including hydroxyb12), probiotic, astaxanthin, iodine
Depression and anxiety guide: http://www.peaktestosterone.com/Help_Anxiety_Depression.aspx

Electrisio

  • Newbie
  • *
  • Posts: 6
    • View Profile
Re: Calcium D-Glucarate Can Really Increase Libido
« Reply #4 on: January 10, 2017, 05:28:03 am »
How long does it typically take CDG to start working/ become at peak effectiveness?
« Last Edit: January 10, 2017, 05:42:20 pm by PeakT »

Peak Testosterone Forum

Re: Calcium D-Glucarate Can Really Increase Libido
« Reply #4 on: January 10, 2017, 05:28:03 am »

PLEASE SUPPORT THE SITE AND GIVE AN AMAZON REVIEW IF POSSIBLE:


Osprey

  • Hero Member
  • *****
  • Posts: 1007
    • View Profile
Re: Calcium D-Glucarate Can Really Increase Libido
« Reply #5 on: January 10, 2017, 06:32:22 am »
My current TRT provider has me on low dose anastrozole. E2 level is in the lower 20's. Might CDG still be helpful in terms of boosting libido?
« Last Edit: January 10, 2017, 05:42:29 pm by PeakT »

Dr. John Crisler

  • Full Member
  • ***
  • Posts: 104
    • View Profile
Re: Calcium D-Glucarate Can Really Increase Libido
« Reply #6 on: January 10, 2017, 07:47:19 am »
I've seen--and felt--500mg twice per day do wild things for guys' libidos.

Estrogen builds up because (1) too much conversion from T (2) not enough metabolization and break down (3) both.

Ca-d-G helps with the breakdown.

For those on Clomid, it's many times helpful.

Dr Crisler,

Without having to get too nerdy (unless you want to, by all means), how does CDG compare to DIM in terms of breakdown -- i.e., how does it work in contrast to DIM, which works its magic through increasing the 2- (but also unfortunately 4-, meaning carcinogenic) hydroxyestrone pathway? 

Do you prefer one over the other?  How much of a drop in E2 do you tend to see for the 500mg twice per day dose?

Thanks!

Different pathways, and several for Ca-d-G.

I don't see any reason to not take both, but DIM would be first.
« Last Edit: January 10, 2017, 05:42:38 pm by PeakT »
Physician in Age Management Medicine private practice. www.DrJohnCrisler.com

NOTE: Comments on this forum are NOT medical advice and are no substitute for individualized patient care. Please consult your personal physician prior to initiating or changing ANY treatment regimen.

eddy88

  • Full Member
  • ***
  • Posts: 236
    • View Profile
Re: Calcium D-Glucarate Can Really Increase Libido
« Reply #7 on: January 10, 2017, 12:09:29 pm »
I've seen--and felt--500mg twice per day do wild things for guys' libidos.

Estrogen builds up because (1) too much conversion from T (2) not enough metabolization and break down (3) both.

Ca-d-G helps with the breakdown.

For those on Clomid, it's many times helpful.

But what about guys on clomid only who retain E2 between 20-30?  My last test showed an E2 of 26, I think this is a good level, no?
« Last Edit: January 10, 2017, 05:42:46 pm by PeakT »
28 years old
ED started Feb. 2016.

Pre-clomid lab numbers:
Total T --> 313/349/258 (249-836)
Free T --> 79.87/59.65 (30-150)
SHBG --> 22/19 (10-57)
LH --> 4.3/3.1 (1.7-8.6)
FSH --> 1.7/1.6 (1.5-12.4)
Prolactin --> 5.1 (4-15.2)
Estradiol --> 11.42/24.06 (7.02-49.06)

Started taking clomid September 2016.  Tested Oct 5 and November 30:

Total T --> 649/502 (249-836)
Free T --> 149/123 (30-150)
SHBG --> 26/21 (10-57)
LH --> 7.7/7.3 (1.7-8.6)
FSH --> 2.3/1.9 (1.5-12.4)
Prolactin --> 11.3/9.4 (4-15.2)
Estradiol --> 29.49/26.32 (7.02-49.06)

Off clomid Jan 16, 2017 due to no improvement in symptoms.

Current symptoms:  low libido and erectile dysfunction.
Currently seeking a functional medicine solution.

Peak Testosterone Forum

Re: Calcium D-Glucarate Can Really Increase Libido
« Reply #7 on: January 10, 2017, 12:09:29 pm »



Dr. John Crisler

  • Full Member
  • ***
  • Posts: 104
    • View Profile
Re: Calcium D-Glucarate Can Really Increase Libido
« Reply #9 on: January 10, 2017, 08:03:29 pm »
I've seen--and felt--500mg twice per day do wild things for guys' libidos.

Estrogen builds up because (1) too much conversion from T (2) not enough metabolization and break down (3) both.

Ca-d-G helps with the breakdown.

For those on Clomid, it's many times helpful.
The C-d-G and DIM help break down the estrogen in Clomid, too.
But what about guys on clomid only who retain E2 between 20-30?  My last test showed an E2 of 26, I think this is a good level, no?
Physician in Age Management Medicine private practice. www.DrJohnCrisler.com

NOTE: Comments on this forum are NOT medical advice and are no substitute for individualized patient care. Please consult your personal physician prior to initiating or changing ANY treatment regimen.

kregger

  • Full Member
  • ***
  • Posts: 184
    • View Profile
Re: Calcium D-Glucarate Can Really Increase Libido
« Reply #10 on: January 11, 2017, 05:39:29 pm »
I'm curious about CDG too. Can someone lists some brands which they've tried and had positive results?
1st Labs:
Total Testosterone: 497 (range is 348 - 1197)
Free Testosterone: 6.1 (range is 8.7 - 25.1)
DHEA: 204.2 (range is 102.6 - 416.3)
Luteinizing Hormone: 9.8 (range is 1.7 - 8.6)
Estradiol: 16.2 (range is 8.0 - 35.0)

Started 25mg daily Clomid (through Defy Medical) on 11/03/16

2nd Labs:
Total Testosterone: 962 (range is 348 - 1197)
Free Testosterone: 12.0 (range is 8.7 - 25.1)
DHEA: 377.5 (range is 102.6 - 416.3)
Luteinizing Hormone: 11.4 (range is 1.7 - 8.6)
Estradiol: 26.1 (range is 8.0 - 35.0)

PakMan

  • Full Member
  • ***
  • Posts: 100
    • View Profile
Re: Calcium D-Glucarate Can Really Increase Libido
« Reply #11 on: January 11, 2017, 07:21:11 pm »
I've seen--and felt--500mg twice per day do wild things for guys' libidos.

Estrogen builds up because (1) too much conversion from T (2) not enough metabolization and break down (3) both.

Ca-d-G helps with the breakdown.

For those on Clomid, it's many times helpful.

Is the increase in libido only due to lowered E or is there some other thing going on?

Roger

  • Full Member
  • ***
  • Posts: 215
    • View Profile
Re: Calcium D-Glucarate Can Really Increase Libido
« Reply #12 on: January 11, 2017, 08:40:23 pm »
I've seen--and felt--500mg twice per day do wild things for guys' libidos.

Estrogen builds up because (1) too much conversion from T (2) not enough metabolization and break down (3) both.

Ca-d-G helps with the breakdown.

For those on Clomid, it's many times helpful.

Is the increase in libido only due to lowered E or is there some other thing going on?

That's my question too? Is the increase in libido from Ca-d-G due to the lowering of E2? Or is the increase in libido independent of a lower E2 level? Also, if one's E2 is already in the 20-30 range (which is supposed to be optimal), wouldn't taking Ca-d-G be unwise?
Age: 51
Height: 5'8"
Weight: 175-180 lbs
Body Fat: 10-13%

40 mg test cyp every 3.5 days IM


Kierkegaard

  • Moderator
  • Hero Member
  • *****
  • Posts: 3384
  • Hormone Shrink
    • View Profile
Re: Calcium D-Glucarate Can Really Increase Libido
« Reply #14 on: January 12, 2017, 01:44:20 am »
Interesting stuff here with sources from the Bulletproof blog:

  • High levels of beta-glucuronide increase the number of estrogen receptors.  This means estrogen that would have been excreted is now able to bind to more receptors.  This can cause increased tissue growth, cancer, and even man boobs.

    Estrogen dominance is one of the leading causes of infertility, cancer, and other health problems in women.  One of the most common treatments for high estrogen levels in a drug called tamoxifen.  Tamoxifen has numerous side effects including stroke, blood clots, uterine cancer, and cataracts.

    New research is showing that CDG could be just as effective as Tamoxifen in treating estrogen dominance.1  CDG allows excess estrogen to be passed out of the body.  A review in 2003 said calcium-d-glucarate could be as effective in preventing cancer as Tamoxifen.
    In one study, calcium-d-glucarate was able to reduce the number of estrogen receptors by 48 percent.  Itís also been shown to lower serum estrogen levels by 23 percent.1


    High estrogen is also a problem for men.  Whether your a man or woman, calcium-d-glucarate will help maintain proper hormone balance.

The post also has other big health benefits for CDG, like cancer prevention, liver detox, and dropping LDL cholesterol.

Nerdier stuff here in a medical journal (but very readable): http://www.altmedrev.com/publications/7/4/336.pdf

Main excerpt:

    Estrogen Metabolism Calcium-D-glucarateís inhibition of betaglucuronidase activity allows the body to excrete hormones such as estrogen before they can become reabsorbed. Oral administration of large doses of calcium-D-glucarate have been shown to lower serum estrogen levels in rats by 23 percent.21 Because many breast cancers are estrogen-dependent, calcium-D-glucarateís ability to affect estrogen and other hormone levels has led to Phase I clinical trials at several major cancer centers in the United States. Results of these studies are pending.

Also on betglucuronidase: "Elevated beta-glucuronidase activity is associated with an increased risk for various cancers, particularly hormone-dependent cancers such as breast, prostate, and colon cancers.2"

So basically CDG appears to reduce the number of estrogen receptors as well as how much estrogen the body clears out via inhibition of betaglucuronidase.  Plus a few other big benefits. 

Cool.
"The same thing that makes you live can kill you in the end." -- Neil Young

March 2014: Dx low T (158ng/dl)
September 2015: Dx hypothyroidism, other adrenal hypofunction/low cortisol
Treatment: 30-35 mg cypionate subq E3D, 50 mcg levothyroxine QD; adaptogens
Supplements: fish oil, vitamin D3, magnesium, copper (low in serum), DIM, coq10, B vitamins (including hydroxyb12), probiotic, astaxanthin, iodine
Depression and anxiety guide: http://www.peaktestosterone.com/Help_Anxiety_Depression.aspx

Peak Testosterone Forum

Re: Calcium D-Glucarate Can Really Increase Libido
« Reply #14 on: January 12, 2017, 01:44:20 am »