This is interesting to all the asthma sufferers and anyone on chronic cortecosteroid meds out there. They could be a big reason for low T. As cortecosteroids shut down T production in the testicles without affecting the pituary gland. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2561306/#!po=16.6667
"A rapid action of glucocorticoids on Leydig cell function was also demonstrated. A rapid (30-min) decline of testosterone production was seen in mouse Leydig cells when these cells were exposed to 1.44 ÁM corticosterone (CORT), indicating that a non-genomic mechanism of glucocorticoids in Leydig cells , since the genomic mechanism of glucocorticoids requires hours to register at the protein level . CORT can inhibit cAMP formation in mouse Leydig cells within 15 min . The rapid action of glucocorticoids has been hypothesized to occur via the putative membrane corticosteroid receptor. For example, stress-induced elevation of glucocorticoid levels in newt suppressing male reproductive behavior was suggested via rapid actions at a putative membrane corticosteroid receptor [30, 31]. It remains to be investigated whether the nongenomic actions of CORT on testosterone production in Leydig cells are via a membrane receptor or other mechanisms. The membrane receptor hypothesis for CORT rapid action may be explainable since our preliminary data has shown that 100 nM CORT-BSA conjugate can inhibit testosterone production during 15 min (Figure 1). "