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Author Topic: Steroid Medications Inhibit Testosterone  (Read 2126 times)

werdisback

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Steroid Medications Inhibit Testosterone
« on: April 03, 2017, 08:29:24 pm »
This is interesting to all the asthma sufferers and anyone on chronic cortecosteroid meds out there. They could be a big reason for low T. As cortecosteroids shut down T production in the testicles without affecting the pituary gland.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2561306/#!po=16.6667

"A rapid action of glucocorticoids on Leydig cell function was also demonstrated. A rapid (30-min) decline of testosterone production was seen in mouse Leydig cells when these cells were exposed to 1.44 ÁM corticosterone (CORT), indicating that a non-genomic mechanism of glucocorticoids in Leydig cells [28], since the genomic mechanism of glucocorticoids requires hours to register at the protein level [29]. CORT can inhibit cAMP formation in mouse Leydig cells within 15 min [28]. The rapid action of glucocorticoids has been hypothesized to occur via the putative membrane corticosteroid receptor. For example, stress-induced elevation of glucocorticoid levels in newt suppressing male reproductive behavior was suggested via rapid actions at a putative membrane corticosteroid receptor [30, 31]. It remains to be investigated whether the nongenomic actions of CORT on testosterone production in Leydig cells are via a membrane receptor or other mechanisms. The membrane receptor hypothesis for CORT rapid action may be explainable since our preliminary data has shown that 100 nM CORT-BSA conjugate can inhibit testosterone production during 15 min (Figure 1). "
« Last Edit: April 05, 2017, 06:04:52 pm by PeakT »

PeakT

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Re: Steroid Medications Inhibit Testosterone
« Reply #1 on: April 05, 2017, 06:05:28 pm »
Thx for posting.  We've actually had a couple of interesting threads on this:  I'll see if I can find them later.
If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements. Yes, low T and E.D. are usually medical conditions.  There are potential risk with HRT:  http://www.peaktestosterone.com/testosterone_risks.aspx.
My Health History: http://www.peaktestosterone.com/My_Health_Story.aspx.
And check out my new Peak Testosterone Program on the right side of my home page: http://www.peaktestosterone.com.

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Re: Steroid Medications Inhibit Testosterone
« Reply #1 on: April 05, 2017, 06:05:28 pm »

Marcel_11

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Re: Steroid Medications Inhibit Testosterone
« Reply #2 on: April 20, 2017, 03:32:40 am »
Thanks for this, I am suffering from my chronic asthma problem since I was 10. And I am thinking that is why I still skinny even If I already have 2 children.
Anyone who has never made a mistake has never tried anything new.

PeakT

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Re: Steroid Medications Inhibit Testosterone
« Reply #3 on: April 22, 2017, 12:38:26 am »
Moving this to the other board.  I'm sure a few other guys suspect this has been an issue for them.
If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements. Yes, low T and E.D. are usually medical conditions.  There are potential risk with HRT:  http://www.peaktestosterone.com/testosterone_risks.aspx.
My Health History: http://www.peaktestosterone.com/My_Health_Story.aspx.
And check out my new Peak Testosterone Program on the right side of my home page: http://www.peaktestosterone.com.

JustAskin

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Re: Steroid Medications Inhibit Testosterone
« Reply #4 on: April 22, 2017, 07:49:23 am »
PeakT
I have posted about this with labs to prove.
While on them my T. Levels drop between 200-300 points.

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Re: Steroid Medications Inhibit Testosterone
« Reply #4 on: April 22, 2017, 07:49:23 am »

PLEASE SUPPORT THE SITE AND GIVE AN AMAZON REVIEW IF POSSIBLE:


PeakT

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Re: Steroid Medications Inhibit Testosterone
« Reply #5 on: April 22, 2017, 11:42:56 am »
PeakT
I have posted about this with labs to prove.
While on them my T. Levels drop between 200-300 points.

Hmmm.  I couldn't find it.  What keywords did you use do you think?  Would you write "corticosteroid", "asthma", etc.  I can find it if you give me the likely words you used in your post.
If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements. Yes, low T and E.D. are usually medical conditions.  There are potential risk with HRT:  http://www.peaktestosterone.com/testosterone_risks.aspx.
My Health History: http://www.peaktestosterone.com/My_Health_Story.aspx.
And check out my new Peak Testosterone Program on the right side of my home page: http://www.peaktestosterone.com.

phatphish

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Re: Steroid Medications Inhibit Testosterone
« Reply #6 on: June 02, 2017, 12:06:42 pm »
I don't know about steroids lowering testosterone, but I was on an inhaled steroid for about 15 years and ended up with a prolactinoma. Now I know that it is not proven what causes prolactinomas, but  my Ear ,nose and throat doc told me to NEVER use nasal inhaled steroids again (for allergy relief). I have ran across anecdotal evidence of inhaled  steroids for asthma doing the same. This tumor almost killed me!

PeakT

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Re: Steroid Medications Inhibit Testosterone
« Reply #7 on: June 02, 2017, 04:07:22 pm »
I don't know about steroids lowering testosterone, but I was on an inhaled steroid for about 15 years and ended up with a prolactinoma. Now I know that it is not proven what causes prolactinomas, but  my Ear ,nose and throat doc told me to NEVER use nasal inhaled steroids again (for allergy relief). I have ran across anecdotal evidence of inhaled  steroids for asthma doing the same. This tumor almost killed me!

If you run across any authority based evidence, please post it here.  Case studies included, etc...
If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements. Yes, low T and E.D. are usually medical conditions.  There are potential risk with HRT:  http://www.peaktestosterone.com/testosterone_risks.aspx.
My Health History: http://www.peaktestosterone.com/My_Health_Story.aspx.
And check out my new Peak Testosterone Program on the right side of my home page: http://www.peaktestosterone.com.

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Re: Steroid Medications Inhibit Testosterone
« Reply #7 on: June 02, 2017, 04:07:22 pm »