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Author Topic: Steroid Medications Inhibit Testosterone  (Read 406 times)

werdisback

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Steroid Medications Inhibit Testosterone
« on: April 03, 2017, 08:29:24 pm »
This is interesting to all the asthma sufferers and anyone on chronic cortecosteroid meds out there. They could be a big reason for low T. As cortecosteroids shut down T production in the testicles without affecting the pituary gland.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2561306/#!po=16.6667

"A rapid action of glucocorticoids on Leydig cell function was also demonstrated. A rapid (30-min) decline of testosterone production was seen in mouse Leydig cells when these cells were exposed to 1.44 ÁM corticosterone (CORT), indicating that a non-genomic mechanism of glucocorticoids in Leydig cells [28], since the genomic mechanism of glucocorticoids requires hours to register at the protein level [29]. CORT can inhibit cAMP formation in mouse Leydig cells within 15 min [28]. The rapid action of glucocorticoids has been hypothesized to occur via the putative membrane corticosteroid receptor. For example, stress-induced elevation of glucocorticoid levels in newt suppressing male reproductive behavior was suggested via rapid actions at a putative membrane corticosteroid receptor [30, 31]. It remains to be investigated whether the nongenomic actions of CORT on testosterone production in Leydig cells are via a membrane receptor or other mechanisms. The membrane receptor hypothesis for CORT rapid action may be explainable since our preliminary data has shown that 100 nM CORT-BSA conjugate can inhibit testosterone production during 15 min (Figure 1). "
« Last Edit: April 05, 2017, 06:04:52 pm by PeakT »

PeakT

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Re: Steroid Medications Inhibit Testosterone
« Reply #1 on: April 05, 2017, 06:05:28 pm »
Thx for posting.  We've actually had a couple of interesting threads on this:  I'll see if I can find them later.
If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements. Yes, low T and E.D. are usually medical conditions.  There are potential risk with HRT:  http://www.peaktestosterone.com/testosterone_risks.aspx.
My Health History: http://www.peaktestosterone.com/My_Health_Story.aspx.
And check out my new Peak Testosterone Program on the right side of my home page: http://www.peaktestosterone.com.

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Re: Steroid Medications Inhibit Testosterone
« Reply #1 on: April 05, 2017, 06:05:28 pm »

Marcel_11

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Re: Steroid Medications Inhibit Testosterone
« Reply #2 on: April 20, 2017, 03:32:40 am »
Thanks for this, I am suffering from my chronic asthma problem since I was 10. And I am thinking that is why I still skinny even If I already have 2 children.
Anyone who has never made a mistake has never tried anything new.

PeakT

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Re: Steroid Medications Inhibit Testosterone
« Reply #3 on: April 22, 2017, 12:38:26 am »
Moving this to the other board.  I'm sure a few other guys suspect this has been an issue for them.
If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements. Yes, low T and E.D. are usually medical conditions.  There are potential risk with HRT:  http://www.peaktestosterone.com/testosterone_risks.aspx.
My Health History: http://www.peaktestosterone.com/My_Health_Story.aspx.
And check out my new Peak Testosterone Program on the right side of my home page: http://www.peaktestosterone.com.

JustAskin

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Re: Steroid Medications Inhibit Testosterone
« Reply #4 on: April 22, 2017, 07:49:23 am »
PeakT
I have posted about this with labs to prove.
While on them my T. Levels drop between 200-300 points.

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Re: Steroid Medications Inhibit Testosterone
« Reply #4 on: April 22, 2017, 07:49:23 am »

PLEASE SUPPORT THE SITE AND GIVE AN AMAZON REVIEW IF POSSIBLE:


PeakT

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Re: Steroid Medications Inhibit Testosterone
« Reply #5 on: April 22, 2017, 11:42:56 am »
PeakT
I have posted about this with labs to prove.
While on them my T. Levels drop between 200-300 points.

Hmmm.  I couldn't find it.  What keywords did you use do you think?  Would you write "corticosteroid", "asthma", etc.  I can find it if you give me the likely words you used in your post.
If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements. Yes, low T and E.D. are usually medical conditions.  There are potential risk with HRT:  http://www.peaktestosterone.com/testosterone_risks.aspx.
My Health History: http://www.peaktestosterone.com/My_Health_Story.aspx.
And check out my new Peak Testosterone Program on the right side of my home page: http://www.peaktestosterone.com.

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Re: Steroid Medications Inhibit Testosterone
« Reply #5 on: April 22, 2017, 11:42:56 am »