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Author Topic: How High Is High Estradiol?  (Read 628 times)

PeakT

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How High Is High Estradiol?
« on: May 04, 2017, 06:58:39 pm »
Nelson Vergel did a great interview with Dr. Ramasamy.  Dr. Ramasamy basically echoes everything that I have said about estradiol, so I was pretty happy with that, i.e. he points out some of the risks of overly high estradiol including gyno, water retention (and high bloood pressure), clotting, atherosclerosis and he also mentions a new one - venous leak.  All of that said, he does not put his patients on anastrozole unless they have quite high (by most guy's standards on here) estradiol around 60 pg/ml.  So you'll have to read his justification for that and discuss with your doc:

https://www.excelmale.com/showthread.php?10539-Estradiol-in-Men-Interview-with-Urology-Professor-Dr-Ranjith-Ramasamy

Interesting stuff and let me know what you think.
If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements. Yes, low T and E.D. are usually medical conditions.  There are potential risk with HRT:  http://www.peaktestosterone.com/testosterone_risks.aspx.
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sh1209

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Re: How High Is High Estradiol?
« Reply #1 on: May 04, 2017, 07:25:05 pm »
Very interesting article.

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Re: How High Is High Estradiol?
« Reply #1 on: May 04, 2017, 07:25:05 pm »

electrify

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Re: How High Is High Estradiol?
« Reply #2 on: May 04, 2017, 07:57:53 pm »
Good interview. My E2 has generally been normal in the low 30s. I dont feel great but doubt its E2 related.

We need a webinar or interview on the impact of TRT on non gonadal axis hormones. For some reason its just never talked about much except on these anecdotal forums! But something has gotta be happening there!
Cortisol, Serum AM (4.0-22.0 mcg/dL):
Testosterone, Total (250-1100 ng/dL): 420
DHEA-S: 550 (24-537 mcg/dL)
Estradiol: 16
DHT: 31 ng/dL (30-85)

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Sportsfan8724

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Re: How High Is High Estradiol?
« Reply #3 on: May 04, 2017, 08:48:03 pm »
Is he saying the ideal ratio of testosterone to estradiol is only ten to one??? That seems really low!

PeakT

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Re: How High Is High Estradiol?
« Reply #4 on: May 04, 2017, 09:50:46 pm »
Is he saying the ideal ratio of testosterone to estradiol is only ten to one??? That seems really low!

Well, I am not sure about 10:1 but pretty close if I understand right.
If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements. Yes, low T and E.D. are usually medical conditions.  There are potential risk with HRT:  http://www.peaktestosterone.com/testosterone_risks.aspx.
My Health History: http://www.peaktestosterone.com/My_Health_Story.aspx.
And check out my new Peak Testosterone Program on the right side of my home page: http://www.peaktestosterone.com.

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Re: How High Is High Estradiol?
« Reply #4 on: May 04, 2017, 09:50:46 pm »

PLEASE SUPPORT THE SITE AND GIVE AN AMAZON REVIEW IF POSSIBLE:


electrify

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Re: How High Is High Estradiol?
« Reply #5 on: May 04, 2017, 11:21:55 pm »
Is he saying the ideal ratio of testosterone to estradiol is only ten to one??? That seems really low!

Well, I am not sure about 10:1 but pretty close if I understand right.

10:1?? Does that mean for 600-700 T he is saying 60-70 E2? That seems quite high...
Cortisol, Serum AM (4.0-22.0 mcg/dL):
Testosterone, Total (250-1100 ng/dL): 420
DHEA-S: 550 (24-537 mcg/dL)
Estradiol: 16
DHT: 31 ng/dL (30-85)

Age:22

anton3196

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Re: How High Is High Estradiol?
« Reply #6 on: May 05, 2017, 03:38:53 am »
you know what guys it makes perfect sense for me (ratio 10:1).. i was never able to feel right when i had total t 1000~ and e2 20-30pg/ml.. didn't have any benefit from having testosterone that high thought something is wrong with my body.. but having total t 700~ and e2 50+ actually felt fantastic

53chevy

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Re: How High Is High Estradiol?
« Reply #7 on: May 05, 2017, 04:28:09 am »
If he thinks an E of 60+ is right for everybody then I feel sorry for some of his patients. Not everybody is the same. When my e gets in the low 30s it's very very bad for me. Treat the symptoms not numbers.

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Re: How High Is High Estradiol?
« Reply #7 on: May 05, 2017, 04:28:09 am »


Osprey

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Re: How High Is High Estradiol?
« Reply #8 on: May 05, 2017, 06:48:14 am »
If he thinks an E of 60+ is right for everybody then I feel sorry for some of his patients. Not everybody is the same. When my e gets in the low 30s it's very very bad for me. Treat the symptoms not numbers.

In the transcript of the interview he says this:

"... And we use basically that same concept, and looked at our patients on testosterone to see if men who were receiving Arimidex, or who have lower estradiol level would report differences in libido and that's basically what we've found. So, for men on testosterone therapy their estrogen levels should not just brought down just because they may go often to the abnormal range. You should use it carefully and base it on symptoms."

PeakT

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Re: How High Is High Estradiol?
« Reply #9 on: May 05, 2017, 06:55:04 am »
you know what guys it makes perfect sense for me (ratio 10:1).. i was never able to feel right when i had total t 1000~ and e2 20-30pg/ml.. didn't have any benefit from having testosterone that high thought something is wrong with my body.. but having total t 700~ and e2 50+ actually felt fantastic

Hydranted wrote once he feels better in the low 40s. Maybe he'll chime in
If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements. Yes, low T and E.D. are usually medical conditions.  There are potential risk with HRT:  http://www.peaktestosterone.com/testosterone_risks.aspx.
My Health History: http://www.peaktestosterone.com/My_Health_Story.aspx.
And check out my new Peak Testosterone Program on the right side of my home page: http://www.peaktestosterone.com.

Cataceous

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Re: How High Is High Estradiol?
« Reply #10 on: May 05, 2017, 07:50:23 am »
It's interesting that Dr. Ramasamy doesn't see a correlation between excess adipose tissue and higher estradiol.
I am not a medical doctor; any suggestions are meant to be discussed with your doctor.
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53chevy

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Re: How High Is High Estradiol?
« Reply #11 on: May 05, 2017, 11:34:59 am »
If he thinks an E of 60+ is right for everybody then I feel sorry for some of his patients. Not everybody is the same. When my e gets in the low 30s it's very very bad for me. Treat the symptoms not numbers.

In the transcript of the interview he says this:

"... And we use basically that same concept, and looked at our patients on testosterone to see if men who were receiving Arimidex, or who have lower estradiol level would report differences in libido and that's basically what we've found. So, for men on testosterone therapy their estrogen levels should not just brought down just because they may go often to the abnormal range. You should use it carefully and base it on symptoms."

At least he has enough sense to go by symptoms. That's a huge plus.

Sportsfan8724

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Re: How High Is High Estradiol?
« Reply #12 on: May 05, 2017, 11:50:09 am »
If any two doctors had the same viewpoint this topic would be more understandable lol

HRT Guru

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Re: How High Is High Estradiol?
« Reply #13 on: May 05, 2017, 06:18:46 pm »
remember from the article to get a 10:1 you have to convert the normal E of pg/mL to ng/dl and then do the ratio. still seems hinky to me though. I've been up over 50 to as much as 88 the night sweats/overly warm plus being PMSish and aggressive were negatively impacting my life.
But then I have low SHBG and (specualate) high Free E so I have a particular part that may have me as an outlier.

Dr Justin Saya, MD

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Re: How High Is High Estradiol?
« Reply #14 on: May 05, 2017, 06:27:06 pm »
remember from the article to get a 10:1 you have to convert the normal E of pg/mL to ng/dl and then do the ratio. still seems hinky to me though. I've been up over 50 to as much as 88 the night sweats/overly warm plus being PMSish and aggressive were negatively impacting my life.
But then I have low SHBG and (specualate) high Free E so I have a particular part that may have me as an outlier.

That would actually be even worse for the 10:1 ratio.

Let's say a total T of 800ng/dl

A 10:1 ratio would be 80ng/dl, which would equate (once converted to the standard pg/ml E2 units) to 800pg/ml.

Although mathematically speaking you should match units for consistency, in these situations one must assume folks are referring to ratios of unadjusted/unmatched units.

I'm assuming the doctor must have misspoke when referring to 10:1 ratio with SAME units.
« Last Edit: May 05, 2017, 06:49:00 pm by Dr Justin Saya, MD »
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Re: How High Is High Estradiol?
« Reply #14 on: May 05, 2017, 06:27:06 pm »