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Author Topic: Weight gain coming off Anastrazole?  (Read 514 times)

Nocturne

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Weight gain coming off Anastrazole?
« on: June 14, 2017, 03:40:55 am »
Stopped taking my .25 mg E4D Anastrazole about 2 weeks ago, and have been gradually gaining weight since.  Was keeping it below 165 for a very long time, this morning I was 167 and change.  Could there be a connection?
43 years old
5'7", was 220 pounds when trouble started, now down to 165
Trouble began with abrupt ED Early May '15
Initial T level 130
Started Clomid in hopes of rebooting system June '15
Currently taking 25 mg eod and .25 mg Arimidex every 4 days
T level 480 or so at last reading
ED in check with 2.5 mg Cialis eod and supplements:
POM juice, L-Cit, Pycnogenol

Morning anxiety currently in check with GABA taken every night

Biggest current worry is heart health:
Aortic stenosis (very mild for now)
CAC score 156(!) at age 42
Lp(a) is a shockingly bad 390 nmol/L -- TRIPLE the "extremely high risk" level!
Homozygous for the bad "G" variant of SNP rs10455872, which increases Lp(a) as well as odds for aortic stenosis and coronary artery lesions. 
I think I know what trashed my heart...

40 mg Crestor and baby aspirin every day
CoQ-10, Vitamin K2, and Kyolic Aged Garlic Extract every day too
Walking 10,000 steps a day

IamTheOneWhoKnocks

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Re: Weight gain coming off Anastrazole?
« Reply #1 on: June 14, 2017, 03:52:12 am »

Could be water retention as your E2 levels will surely rise in the absence of your AI.

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Re: Weight gain coming off Anastrazole?
« Reply #1 on: June 14, 2017, 03:52:12 am »

Nocturne

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Re: Weight gain coming off Anastrazole?
« Reply #2 on: June 14, 2017, 05:15:35 am »
E2 makes you retain water?  Like salt?  Damn.
43 years old
5'7", was 220 pounds when trouble started, now down to 165
Trouble began with abrupt ED Early May '15
Initial T level 130
Started Clomid in hopes of rebooting system June '15
Currently taking 25 mg eod and .25 mg Arimidex every 4 days
T level 480 or so at last reading
ED in check with 2.5 mg Cialis eod and supplements:
POM juice, L-Cit, Pycnogenol

Morning anxiety currently in check with GABA taken every night

Biggest current worry is heart health:
Aortic stenosis (very mild for now)
CAC score 156(!) at age 42
Lp(a) is a shockingly bad 390 nmol/L -- TRIPLE the "extremely high risk" level!
Homozygous for the bad "G" variant of SNP rs10455872, which increases Lp(a) as well as odds for aortic stenosis and coronary artery lesions. 
I think I know what trashed my heart...

40 mg Crestor and baby aspirin every day
CoQ-10, Vitamin K2, and Kyolic Aged Garlic Extract every day too
Walking 10,000 steps a day

HRT Guru

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Re: Weight gain coming off Anastrazole?
« Reply #3 on: June 14, 2017, 10:13:43 am »
2lbs...maybe you just need to take a dump.

hello73

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Re: Weight gain coming off Anastrazole?
« Reply #4 on: June 14, 2017, 11:23:24 am »
Best time to weigh yourself is in the AM with nothing on except maybe an underwear. Preferably after bowel movement and urinating. First thing in the morning it too can fluctuate by you will have better results vs weighing yourself during the day. The scale measures the water, food, organs you name it. If you are lifting you could be losing inches before you lose pounds.

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Re: Weight gain coming off Anastrazole?
« Reply #4 on: June 14, 2017, 11:23:24 am »

PLEASE SUPPORT THE SITE AND GIVE AN AMAZON REVIEW IF POSSIBLE:


ChrisCanada

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Re: Weight gain coming off Anastrazole?
« Reply #5 on: June 14, 2017, 09:40:39 pm »
When I become bloated, I am well-aware that my estradiol has gotten too high.  Its one of the most obvious signs of high e2 for me.

Anastrozole lowers E2 which therefore, lowers your water retention caused by high estradiol.

Low E2 can also cause water depletion!

Like the response above, I believe the correlation may be that your E2 is rising again.

Born 1984. ED due to low testosterone began at 15.5 years old.  All typical low T symptoms my entire life (poor concentration, anxiety, lack of sweating, poor metabolism, lack of muscle build despite rigorous gym)
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Nocturne

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Re: Weight gain coming off Anastrazole?
« Reply #6 on: June 16, 2017, 03:32:21 am »
Funny thing -- I had two very vivid dreams last night.  One was horrific and ended when I woke up screaming.  The other was very pleasant -- I was in college and fell in love with a pretty young woman, all fresh romance and tickle-kissy-petty and breathless learning about each other (then I woke up and felt a dim sense of loss that it was all gone, until I felt my wife next to me and remembered that I already had HER).

Point is, I've struggled with a lack of dreams since my T shut down, and now this after cutting Adex.  I dunno if there is a correlation.  And it may be that I am still in a honeymoon period.  ???

Morning erections have been passable but not great (like they were 3-4 years ago).  Am unsure if they are worse than before I dropped the Adex or not.
43 years old
5'7", was 220 pounds when trouble started, now down to 165
Trouble began with abrupt ED Early May '15
Initial T level 130
Started Clomid in hopes of rebooting system June '15
Currently taking 25 mg eod and .25 mg Arimidex every 4 days
T level 480 or so at last reading
ED in check with 2.5 mg Cialis eod and supplements:
POM juice, L-Cit, Pycnogenol

Morning anxiety currently in check with GABA taken every night

Biggest current worry is heart health:
Aortic stenosis (very mild for now)
CAC score 156(!) at age 42
Lp(a) is a shockingly bad 390 nmol/L -- TRIPLE the "extremely high risk" level!
Homozygous for the bad "G" variant of SNP rs10455872, which increases Lp(a) as well as odds for aortic stenosis and coronary artery lesions. 
I think I know what trashed my heart...

40 mg Crestor and baby aspirin every day
CoQ-10, Vitamin K2, and Kyolic Aged Garlic Extract every day too
Walking 10,000 steps a day

anton3196

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Re: Weight gain coming off Anastrazole?
« Reply #7 on: June 16, 2017, 06:54:29 am »
if you had too low e2 on adex then stopped - you will gain water which suppose to be there.. water weight on trt is ok to some extent (it's not just about E, having T in high end range will make you retain more water esp on injectables since levels don't fluctuate and you have high T levels every hour every day).. usually after quiting AI's you gain some water retention which goes away after some time (I can't explain this but me and many others have experienced this) and it doesn't mean that your e2 shot too high (well sometimes but not that often on TRT doses of testosterone)
just give it some time it will stabilize
« Last Edit: June 16, 2017, 06:56:31 am by anton3196 »

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Re: Weight gain coming off Anastrazole?
« Reply #7 on: June 16, 2017, 06:54:29 am »


PeakT

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Re: Weight gain coming off Anastrazole?
« Reply #8 on: June 19, 2017, 07:14:48 am »
Funny thing -- I had two very vivid dreams last night.  One was horrific and ended when I woke up screaming.  The other was very pleasant -- I was in college and fell in love with a pretty young woman, all fresh romance and tickle-kissy-petty and breathless learning about each other (then I woke up and felt a dim sense of loss that it was all gone, until I felt my wife next to me and remembered that I already had HER).

Point is, I've struggled with a lack of dreams since my T shut down, and now this after cutting Adex.  I dunno if there is a correlation.  And it may be that I am still in a honeymoon period.  ???

Morning erections have been passable but not great (like they were 3-4 years ago).  Am unsure if they are worse than before I dropped the Adex or not.

As the guys said, any increase in estradiol could increase water retention.  Now I haven't seen any studies tieing in estradiol to erotic dreams, so you're on your own that one.  I will tell you that LOTS of research shows estradiol has a profound and largely beneficial benefit on the brain.  This is one of the reasons that guys who have crashed their estradiol feel so lousy.  Check this out:

https://www.ncbi.nlm.nih.gov/pubmed/25540977

"The gonadal hormone estradiol modulates mesolimbic dopamine systems in the female rat. This modulatory effect is thought to be responsible for the observed effects of estradiol on motivated behaviors. Dopamine acting in the nucleus accumbens is thought to be important for the attribution of incentive motivational properties to cues that predict reward delivery, "

This is on female rats but should be largely the same in males.

I'm sure you've seen the research that shows that low estradiol produces all the classic "low testosterone" sexual symptoms.  Look at the words in the abstract above and so maybe there is something to that after all?

"Elevated concentrations of estradiol are associated with increased motivation for sex or cues associated with access to a mate..."
« Last Edit: June 19, 2017, 07:16:53 am by PeakT »
If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements. Yes, low T and E.D. are usually medical conditions.  There are potential risk with HRT:  http://www.peaktestosterone.com/testosterone_risks.aspx.
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Re: Weight gain coming off Anastrazole?
« Reply #8 on: June 19, 2017, 07:14:48 am »