Sex Hormone Binding Globulin (SHBG) is the major serum carrier of sex hormones. However, growing evidence suggests that SHBG is internalised and plays a role in regulating intracellular hormone action. This study was to determine whether SHBG plays a role in testosterone uptake, metabolism, and action in the androgen sensitive LNCaP prostate cancer cell line.
Oh my goodness, what a gem. This explains a heck of a lot in my opinion.
The thesis of this article is that you need SHBG INSIDE your cells for protection and inhibition of androgens. Check out this statement:
"Testosterone was rapidly taken up and effluxed as testosterone-glucuronide; however this effect was reduced by the presence of SHBG. Addition of SHBG, rather than reducing testosterone bioavailability, further increased testosterone-induced expression of prostate specific antigen and enhanced testosterone-induced reduction of androgen receptor mRNA expression. Following 38 hours of testosterone treatment cell morphology changed and growth declined; however, cotreatment with SHBG abrogated these inhibitory effects. These findings clearly demonstrate that internalised SHBG plays an important regulatory and intracellular role in modifying testosterone action and this has important implications for the role of SHBG in health and disease."
Also, notice that they added SHBG! Maybe I am missing something, but it sounds like SHBG could be compounded and given to men just like testosterone or the hormones?
Anyway, I will probably incur the wrath of some of the low SHBG guys on here, but I think that most low SHBG guys often struggle and quite often react badly to TRT. I think this explains what is going on there.
Check out my pages on low SHBG if you are interested:http://www.peaktestosterone.com/low_shbg.aspx