Finding the right protocol is a time-consuming process, which is frustrating when you want improvements. When is your next set of lab work? On the one hand, some guys respond strongly to anastrozole, and 0.125 mg per day could be too much. But I'm sure Defy has found this to be a good starting dose for the majority. Another consideration is that anastrozole doesn't affect the estrogenic zuclomiphene isomer of Clomid. So until you have new numbers there's not much to say about which way your treatment should go. What were your last SHBG and LH values? Current dose of Clomid?
The main takeaway is that if you stick with it there's a good chance Defy will find a treatment that works for you. It may not be Clomid, but there are other options, including TRT + hCG, which seems to have a much higher rate of success than Clomid. Regardless, think of it as a process that will take many months, but it will be worthwhile if you achieve improvements that persist for years.