Quantcast

Author Topic: Started with defy Ed issues high estradiol and low gh  (Read 154 times)

Riverman1985

  • Newbie
  • *
  • Posts: 5
    • View Profile
Started with defy Ed issues high estradiol and low gh
« on: September 16, 2018, 07:18:16 am »
 http://www.peaktestosterone.com/forum/index.php?topic=14655.msg131645#msg131645
Update from this post

Im a 32 year old married male with ed issues that started in 2016 but before my ed came I started having up and down libido issues, my libido would be normal thru the roof then I'd go a week or 2 with no libido but never any erection issues. I started with defy medical about 5 weeks ago and the phone appointment with the doctor went very well. They pointed out my testosterone and free testosterone looked good (around 560) so continue using the clomid that my urologist prescribed me. My estogen level was at 56 which they stated was way too high it should be between 20-30 range.  They also pointed out my gh is low it was at 94 and it should be in the 200+ range. So I was prescribed Anastrozole and have been on it for 4 weeks now I noticed a delay in ejaculation around the 2nd week but that went away now I'm on week 5 and still dont see much of any improvements on erection quality and loses my erection during intercourse. I'm on 0.125 dose daily. My achy joints did improve a lil. Libido is still down also. I asked about tackling the growth hormone issue but they said they will start that on the next appointment. My erection quality is hit and miss with or without cialis. Clomid resolved my issue when I first started it in 2016 but 3 weeks later it stopped  so i up the dose and it worked again but after 2 weeks the results vanished. Defy said that's probably when my estradiol levels went up after my testosterone went up. Any suggestions?
« Last Edit: September 16, 2018, 07:31:07 am by Riverman1985 »

Cataceous

  • Administrator
  • Hero Member
  • *****
  • Posts: 4568
    • View Profile
Re: Started with defy Ed issues high estradiol and low gh
« Reply #1 on: September 16, 2018, 08:19:06 am »
Finding the right protocol is a time-consuming process, which is frustrating when you want improvements. When is your next set of lab work? On the one hand, some guys respond strongly to anastrozole, and 0.125 mg per day could be too much. But I'm sure Defy has found this to be a good starting dose for the majority. Another consideration is that anastrozole doesn't affect the estrogenic zuclomiphene isomer of Clomid. So until you have new numbers there's not much to say about which way your treatment should go. What were your last SHBG and LH values? Current dose of Clomid?

The main takeaway is that if you stick with it there's a good chance Defy will find a treatment that works for you. It may not be Clomid, but there are other options, including TRT + hCG, which seems to have a much higher rate of success than Clomid. Regardless, think of it as a process that will take many months, but it will be worthwhile if you achieve improvements that persist for years.
I am not a medical doctor; any suggestions are meant to be discussed with your doctor.
Age: 57, Ht: 5'10", Wt: 158 lbs
Protocol: 18 mg T enanthate subQ qod, 250 IU hCG subQ qod, 50 mcg anastrozole qod, 6.25 mg DHEA orally bid
7/2018 test results: TT: 800 ng/dL, E2: 50 pg/mL immunoassay, DHEA-S: 264 ug/dL (49-344)—SHBG ~30 nmol/L

Peak Testosterone Forum

Re: Started with defy Ed issues high estradiol and low gh
« Reply #1 on: September 16, 2018, 08:19:06 am »


Mindscape

  • Hero Member
  • *****
  • Posts: 534
    • View Profile
Re: Started with defy Ed issues high estradiol and low gh
« Reply #2 on: September 16, 2018, 01:49:05 pm »
I'm one of those over-responders to anastrozole, half of a .125 is enough to knock estrogen down too low. There are other compounding pharmacies through Defy Medical who offer lower dose AI's and you can even dissolve anastrozole in vodka and buy graduated dropper pipettes and dose that way.

It will take time a patience to dial in your TRT protocol, 5 weeks is nothing and will take months to feel dramatic changes if your other hormones are in a healthy range.

Riverman1985

  • Newbie
  • *
  • Posts: 5
    • View Profile
Re: Started with defy Ed issues high estradiol and low gh
« Reply #3 on: September 16, 2018, 07:57:42 pm »
Finding the right protocol is a time-consuming process, which is frustrating when you want improvements. When is your next set of lab work? On the one hand, some guys respond strongly to anastrozole, and 0.125 mg per day could be too much. But I'm sure Defy has found this to be a good starting dose for the majority. Another consideration is that anastrozole doesn't affect the estrogenic zuclomiphene isomer of Clomid. So until you have new numbers there's not much to say about which way your treatment should go. What were your last SHBG and LH values? Current dose of Clomid?

The main takeaway is that if you stick with it there's a good chance Defy will find a treatment that works for you. It may not be Clomid, but there are other options, including TRT + hCG, which seems to have a much higher rate of success than Clomid. Regardless, think of it as a process that will take many months, but it will be worthwhile if you achieve improvements that persist for years.

Shbg was 26.3 on a 16.5-55.3 scale
LH was 8.9
25mg clomid.

Peak Testosterone Forum

Re: Started with defy Ed issues high estradiol and low gh
« Reply #3 on: September 16, 2018, 07:57:42 pm »


Cataceous

  • Administrator
  • Hero Member
  • *****
  • Posts: 4568
    • View Profile
Re: Started with defy Ed issues high estradiol and low gh
« Reply #4 on: September 17, 2018, 04:38:48 am »
If it comes to the point where you're going to give up on Clomid anyway then you might see if a dose reduction helps. In doing this some guys have reported higher testosterone levels, and reduced estrogenic effects would also be expected. Any protocol changes should be given plenty of time to work; the zuclomiphene isomer of Clomid has a half life of 30 days.
I am not a medical doctor; any suggestions are meant to be discussed with your doctor.
Age: 57, Ht: 5'10", Wt: 158 lbs
Protocol: 18 mg T enanthate subQ qod, 250 IU hCG subQ qod, 50 mcg anastrozole qod, 6.25 mg DHEA orally bid
7/2018 test results: TT: 800 ng/dL, E2: 50 pg/mL immunoassay, DHEA-S: 264 ug/dL (49-344)—SHBG ~30 nmol/L

Riverman1985

  • Newbie
  • *
  • Posts: 5
    • View Profile
Re: Started with defy Ed issues high estradiol and low gh
« Reply #5 on: September 17, 2018, 08:35:58 am »
I cycled off of clomid once last year because I felt like it wasnt working anymore and my testosterone dropper to 350 range and estrodiol was 53. Lh was also still elevated. 2018 my testosterone is at 550-600 and estrodiol is at 56 on clomid. I was originally put on clomid as a estrogen blocker but it didnt help my estrogen only helped my testosterone. I feel the same rather my testosterone is at 350 or 550-600. When I first started clomid I felt great and like myself again. My local urologist only checked testosterone and lipid panels. I guess I have to give Anastrozole some more time. I'm also having issues losing weight I'm eating right and exercising but I really dont lose anything but if I dont go I'd gain weight easily so I go pretty consistently

Cataceous

  • Administrator
  • Hero Member
  • *****
  • Posts: 4568
    • View Profile
Re: Started with defy Ed issues high estradiol and low gh
« Reply #6 on: September 17, 2018, 10:33:52 am »
Something's bugging me about your estradiol numbers. So to confirm: Originally you had total testosterone of 358 ng/dL and estradiol via the standard test of 53.6 pg/mL. When starting with Defy you were on 25 mg/day of Clomid and had total testosterone of 560 ng/dL and estradiol via the sensitive test of 56 pg/mL. Is this correct?

If the estradiol test methodologies were the same then these results would be unusual, because Clomid stimulates estradiol production, and testosterone, the source material for estradiol, is 56% higher. But I figure Defy would insist on the sensitive test, so this suggests that the standard test was falsely elevated. If these were my numbers I think I would have my C-reactive protein tested (hsCRP). It's a marker for systemic inflammation that can falsely raise the standard estradiol test. If your level is high then it would be good to take steps to bring it down.
I am not a medical doctor; any suggestions are meant to be discussed with your doctor.
Age: 57, Ht: 5'10", Wt: 158 lbs
Protocol: 18 mg T enanthate subQ qod, 250 IU hCG subQ qod, 50 mcg anastrozole qod, 6.25 mg DHEA orally bid
7/2018 test results: TT: 800 ng/dL, E2: 50 pg/mL immunoassay, DHEA-S: 264 ug/dL (49-344)—SHBG ~30 nmol/L

Riverman1985

  • Newbie
  • *
  • Posts: 5
    • View Profile
Re: Started with defy Ed issues high estradiol and low gh
« Reply #7 on: September 17, 2018, 01:25:35 pm »
Well when the erection issues came out of no where in 2016 my testosterone was in the 200 range which was tested at my local urologist but he never checked estradiol. He prescribed me clomid and in about 2 weeks my libido and erections went back to normal. But after 2-3 weeks it stopped working and erections were weaker so my urologist said to take the whole tablet (50mg) and see what happens so I did and my libido and erections came back for another 2-3 weeks  then it stopped working as well again so I got my testosterone checked and it was in 500 range so he said just keep taking it he never checked my estradiol even after after me asking for it to be checked. So 2017 I stopped taking the clomid for a month or 2 because I felt it didnt work anymore and it was a waste of money to keep buying and i went to a male health clinic and had labs done and my testosterone was in the 358, estrodiol was 53.6, LH was 9.4, free testosterone was a 14.1 with a 8.7-25.1  normal range. They told me I needed THT and a estrogen blocker clomid doesnt raise testosterone. I got back on the clomid and had my testosterone and lipid panel checked at my local urologist 4 months later and my testosterone was at 590 and lipid panels looked great so my local urologist said the male clinic just wanted to sell me their THT program. About 3 months after that I went to Defy after reading around about them. Testosterone was a 545 free testosterone was  22 on a 8.7-25.1 scale. Lh was 8.9, prolactin was a 6.2 on a 4.0-15.2 scale, dhea was 318 on a 138-475 scale, growth hormone was 94 on a 88-246 scale, estradiol sensitive was 56.8,  Shbg was 26.3 on a 16.5-55 scale. My creatinine was high also 1.37 on a 76-1.27 scale. I went to my primary care doctor to report my creatinine level and they said my urine looked good. I've had 2 or 3 diabetes test since this ed came about and they came back normal. Creatinine was at 1.16 on a 76-1.27 scale 96% in November 2017. My primary care physician said the elevated levels could have came from dehydration or a hard workout the day before but urine looked fine.
« Last Edit: September 17, 2018, 01:36:40 pm by Riverman1985 »

Cataceous

  • Administrator
  • Hero Member
  • *****
  • Posts: 4568
    • View Profile
Re: Started with defy Ed issues high estradiol and low gh
« Reply #8 on: September 17, 2018, 03:06:12 pm »
Arguably the standard estradiol test result was elevated because there was still some residual influence from the Clomid after a "month or two," even though testosterone was low. But I'd still check CRP to be sure. The test is only $22 through Defy, and it would be simple to add to the next set of lab work.
I am not a medical doctor; any suggestions are meant to be discussed with your doctor.
Age: 57, Ht: 5'10", Wt: 158 lbs
Protocol: 18 mg T enanthate subQ qod, 250 IU hCG subQ qod, 50 mcg anastrozole qod, 6.25 mg DHEA orally bid
7/2018 test results: TT: 800 ng/dL, E2: 50 pg/mL immunoassay, DHEA-S: 264 ug/dL (49-344)—SHBG ~30 nmol/L

Peak Testosterone Forum

Re: Started with defy Ed issues high estradiol and low gh
« Reply #8 on: September 17, 2018, 03:06:12 pm »