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Author Topic: Can You Regrow New Leydig Cells?  (Read 6357 times)

D-55

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Can You Regrow New Leydig Cells?
« on: July 03, 2012, 05:30:58 pm »
Actually, the study says that varicocele surgery will, on average, raise T a bit.  Some urologists state otherwise though, but I'm just letting you know what the study says.

Does the body have the ability to grow new LEYDIG CELLS?

(Edited - I said Sertoli cells initially!)
« Last Edit: July 03, 2012, 05:46:02 pm by Dermotm55 »
Age: early thirties.
Not on any TRT.
Have Ulcerative Colitis and two significant varicoceles with significant testicular atrophy but a good T level apparently.

PeakT

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Re: Can You Regrow New Leydig Cells?
« Reply #1 on: July 03, 2012, 06:36:39 pm »
You can definitely regenerate new Leydig cells according to this animal study:

http://www.andrologyjournal.org/cgi/content/abstract/12/5/295

http://www.andrologyjournal.org/cgi/reprint/12/5/295.pdf

If you read this article, it looks like estrogen plays a key role in limiting Leydig cell regeneration.

What I'm struggling to find is how late in life you can regenerate them.
« Last Edit: July 03, 2012, 09:43:16 pm by PeakT »
THE MOST COMPREHENSIVE BOOK ON TRT/TESTOSTERONE:
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If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements.  And low testosterone is a medical condition.

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Re: Can You Regrow New Leydig Cells?
« Reply #1 on: July 03, 2012, 06:36:39 pm »

D-55

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Re: Can You Regrow New Leydig Cells?
« Reply #2 on: July 13, 2012, 07:21:32 am »
This paper suggests that v correction should be done before age 30. I am 30 so I wonder if it's worth getting it fixed now. Testicles are small (4.5cm or less in length) and usually soft. Sometimes very soft, like 'mush'.

http://ir2.nul.nagoya-u.ac.jp/jspui/bitstream/2237/16083/1/v58n12p47_50.pdf

I face a battle with my GPs simply to be referred. They look at me as if I am insane when I mention this as being a problem. They probably won't freely refer me under the NHS so I will have to ask them to refer me privately at my own cost.
Age: early thirties.
Not on any TRT.
Have Ulcerative Colitis and two significant varicoceles with significant testicular atrophy but a good T level apparently.

PeakT

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Re: Can You Regrow New Leydig Cells?
« Reply #3 on: July 13, 2012, 10:21:05 am »
Great paper!  Thx for posting that.  I can't believe you have to pay for that - ouch!
THE MOST COMPREHENSIVE BOOK ON TRT/TESTOSTERONE:
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And check out my New Peak Testosterone Program: http://www.peaktestosterone.com/peak_testosterone_program.aspx
If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements.  And low testosterone is a medical condition.

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Re: Can You Regrow New Leydig Cells?
« Reply #3 on: July 13, 2012, 10:21:05 am »


D-55

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Re: Can You Regrow New Leydig Cells?
« Reply #4 on: July 13, 2012, 11:45:36 am »
I feel pretty bad about the whole thing.

I may have to resign myself to living with the condition and making the best of whatever is left of my life. That may well involve diminishing T levels. I could only afford TRT if I won the lottery.

Hopefully, I will get referred to a urologist. I'll see what he has to say, and then I might have the option of surgery or maybe embolization.

Peak T, in order to get a fair result from the T blood test (which I hope to get done next week), I thought it would make sense to get a normal night's sleep. At present, I am getting up at around 2pm and going to bed at around 4am. For the T test, I'd like to go to sleep at or before 12 midnight and get up at 815am or so in order to go and get the blood test at 9am (as the centre does not open 'til 9am). Would it affect the T test results if I'd taken a Melatonin tablet the night before or even the preceding few nights before? I may or may not need the tablet to get to sleep but it is quite likely that I will lie worrying about not sleeping, knowing I need a good night's sleep to get a fair T test result...

Part of me is actually hoping for a disappointing T result, if only to confirm that there is justification for feeling crap and to prove that small testicles because of V is causing problems, and this might prompt the GP to refer me. I'd be surprised if my results were about 500, but we shall see next week. Of course, it would be nice to see healthy levels, but I can't expect they will be.
« Last Edit: July 13, 2012, 12:34:05 pm by Dermotm55 »
Age: early thirties.
Not on any TRT.
Have Ulcerative Colitis and two significant varicoceles with significant testicular atrophy but a good T level apparently.

PeakT

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Re: Can You Regrow New Leydig Cells?
« Reply #5 on: July 13, 2012, 12:39:05 pm »
I encourage to just go about your regular routine and see where your T lands.  Melatonin can affect T a little but not enough to likely make a difference.

But you want to see where your T is at "living your life".

Also, I know some U.K. folks go to France and are able to enroll in the French system.  Could that possibly help?
THE MOST COMPREHENSIVE BOOK ON TRT/TESTOSTERONE:
https://www.amazon.com/Natural-Versus-Testosterone-Therapy-Myer/dp/1523210532/ref=sr_1_1?ie=UTF8&qid=1499116128&sr=8-1&keywords=natural+versus+testosterone+therapy
And check out my New Peak Testosterone Program: http://www.peaktestosterone.com/peak_testosterone_program.aspx
If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements.  And low testosterone is a medical condition.

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Re: Can You Regrow New Leydig Cells?
« Reply #5 on: July 13, 2012, 12:39:05 pm »