As some of you may know, my PSA shot up from about 1.4 ng/ml to a high of 6.3 in early December of 2013. Yeah, Merry Christmas! I was immediately forced off of HRT (testosterone therapy) for a month and ended up with a prostate biopsy. Fortunately, they found Only Inflammation and No Cancer.
This was a sobering experience for me as I consider myself to be very healthy overall. To this day, I still do not really know what caused the prostate inflammation. However, I do have good news: last week (4/25/2014) I found that my PSA was down to 2.0! So it took about five months, but I almost have my PSA back down to my original baseline levels. I had an interim read of 3.9 as well, even though my prostate was likely still inflamed from the biopsy, so I was showing improvement almost right away.
Of course, I’d like to have a baseline PSA less than 1.0 like some of the young guys on the Peak Testosterone Forum, but I’m on HRT, am sexually active – hallelujah! – and exercise every day. All of these will tend to raise PSA and so a PSA of 1.4 is not too unreasonable for a guy in his early 50’s in my opinion.
And, of course, I am very excited that I have reduced my PSA now by over three times in just a few months and thought I’d share – humbly of course – what I have done. Before I go on, let me say thanks to Mike Shedlock who gave me the core ideas for a good deal of what you see below on the supplement side of things and who was a role model for all of us by dropping his PSA with an innovative nutraceutical solution. I cover all this in my link on A Cure For Prostate Cancer and am a regular reader of Mike Shedlock’s blog at Global Economic Analysis.
CAUTION: I want to caution anyone reading this with actual prostate cancer. PC is a tricky disease and you have to be careful. I highly recommend that you run anything that you are considering below by your urologist and a good oncologist. (Most urologists are woefully ignorant on the underlying cancer mechanisms behind prostate cancer from what I have seen.) And, of course, stay up on the latest research and share it with me!
- Turmeric Extract (400 mg as extract with 93% curcuminoids of 372 mg twice per day)
- IP6 & Inositol (800 mg and 220 mg, respectively, once per day)
- Quercetin (250 mg once per day)
- Bromelain (125 mg once per day)
- Red Tart Cherry – Freeze Dried Skin Concentrate in Capsules (1000 mg once per day)
NOTE: Almost everything in my current regimen is anti-inflammatory. Both prostatitis and prostate cancer are, in general improved by anti-inflammatory strategies, so this is a pretty safe bet in my opinion. I should point out that the long term effects of supplements, especially megadosing are largely unknown.
- Curry once per day
- Soy Protein once per day. (For a few cautions, see my link Soy and Men. In addition, keep in mind that some study work shows that soy increases IGF-1 and higher IGF-1 levels are linked with increased prostate cancer risk. )
- I put 3-4 tablespoons of flaxseed in my smoothie every day. (See my link on Flaxseed and Prostate Cancer for some additional information.)
- Diet is completely vegan except for
- a) (BPA-free) sardines three times per week and
- b) Undenatured whey which one study showed did not increase IGF-1
NOTE: I am not anti-meat as you can see in my link on Low Fat Meats. However, some study work shows that veganism lowers IGF-1 to more natural cancer-protecting levels, so I am currently playing it safe.
NEWS FLASH: My latest PSA in mid late 2015 was 1.75. I was very please with that, because this is almost to my old levels when I first started testosterone cypionate. Lately, the only direct PSA-lowering strategies have been turmeric extract and flaxseed, along with my standard plant-based flexitarian diet, exercise routines and anti-aging supplement strategy.
- MODIFICATIONS from MISH’s PSA-Lowering Protocol:
As you can see,I took MISH’s PSA-lowering protocol as my starting point and simply did a few tweaks. Keep in mind, though, that he dropped his PSA dramatically and he had actual prostate cancer detected, so his results are particularly impressive.
- Resveratrol: I do not use Resveratrol, because there is one study out there that showed that initially it reversed prostate cancer and later fueled it. Many nutraceuticals are just as potent as pharmaceuticals and can have unexpected side effects and this is one where I am waiting for more study work to be done.
- I3C: As mentioned above, I eat a lot of cabbage every day, which has a goodly amount of I3C. And the Japanese, for example, consume near-supplement proportions of I3C in their diet (112 mg).  However, I do not consume I3C as a supplement, because it has been shown in some studies to be dependent on timing. The Linus Pauling Institute points out that “I3C has been found to inhibit the development of cancer in animals when given before or at the same time as a carcinogen. However, in some cases, I3C enhanced the development of cancer in animals when administered after a carcinogen.”  However, there is abundant epidemiolical evidence tying cruciferous vegetable consumption to lowered prostate cancer risk, so I feel this is the more safe route to go.
1) Nutr Cancer, 2007, 58(1):35-42, “Relationship of dietary protein and soy isoflavones to serum IGF-1 and IGF binding proteins in the Prostate Cancer Lifestyle Trial”