Over and over and over again I read Paleo and Low Carb bloggers state that cholesterol and LDL do not matter. This is incredibly deceptive, because LDL-C and total cholesterol are more often than not related to the LDL Particle Count (LDL-P) and it DOES matter in that case. LDL-P matters, and it matters a lot. Study after study after study has shown that, if your LDL-P is too high, you will build up arterial plaque. This is something I show in my page on LDL-P: The Best Predictor of Heart Disease. And does anyone doubt that it would not also be the best predictor of erectile dysfunction? Clogged penile arteries are not going to help you in the bedroom.
To show you how far we have deviated from our natural physiology, I am going to start with a quote from Loren Cordain, the founder of the modern Paleo movement:
"The normal low-density lipoprotein (LDL) cholesterol range is 50 to 70 mg/dl for native hunter-gatherers, healthy human neonates, free-living primates, and other wild mammals (all of whom do not develop atherosclerosis). Randomized trial data suggest atherosclerosis progression and coronary heart disease events are minimized when LDL is lowered to <70 mg/dl. No major safety concerns have surfaced in studies that lowered LDL to this range of 50 to 70 mg/dl. The current guidelines setting the target LDL at 100 to 115 mg/dl may lead to substantial undertreatment in high-risk individuals." 
Yes, the father of modern Paleo wrote a journal article explaining that ALL Paleo/primal cultures had LDL between 50 to 70! He also admitted that arterial plaque (atherosclerosis) was minimal in these cultures. Also, all of these cultures had total cholesterol below 150.
High cholesterol and high LDL are simply NOT natural for men. Period. Straight from Loren Cordain's research: if you cholesterol is over 150 and your LDL is over 70, you can't really call yourself primal or "Paleo" - period.
Of course, you can call yourself anything you want - I don't care. But you get my point: there is no evidence that Paleo people had cholesterol over 150 consistently. And from Dr. Cordain's study we can clearly come to the conclusion that total cholesterol below 150 and LDL below is 70 is actually natural for human beings on this planet.
And don't let this slip escape your notice: these Paleo cultures had the LDL levels of higher dose statin users. I'm not here to preach statins due to their side effects. But this shows you how high our cholesterol and LDL is due to eating unnatural industrial meats and oils. We have to go on big gun statins just to get our numbers down to where the primal cultures are.
And please don't say "but LDL that low is dangerous!"
Really? So every single Paleo/primal culture was living dangerously?!
Doesn't that strike you as odd? I have read many times Paleo leaders state that low cholesterol and LDL is dangerous not realizing that the father of their movement proved that it is actually natural and healthy. I wonder how many of their followers have had heart attacks, because they got the idea that high cholesterol, LDL and even LDL-P are critical for good health??
"Cholesterol is important for brain health." Well, who on this planet disputes that? But the primal peoples clearly showed that cholesterol in the 100-150 range is ample cholesterol for your brain.
Let me tell you what is NOT good for your brain: calcification. There is a lot of evidence that calcification, i.e. plaque buildup, in the delicate capillaries and tissues of the brain play a role in Parkinson's and Alzheimers. Your brain needs you to keep it clean and clear. Dumping a bunch of industrail oil and meat into your non-carnivore gut/intestine is risky unless you are one of the lucky guys with lower LDL-P levels on that kind of diet.
Again, I realize that LDL-P is a much more important number than LDL and total cholesterol, and I cover that extensively on my site: Regressing Penile and Arterial Plaque Pages. But I also recognize that high cholesterol and LDL are just not something that men experienced here on planet earth until recently.
Please don't object that some men have cholesterol > 150 and have good LDL-P numbers. I know that. However, these men are not common and that is the tragedy. Yes, you can theoretically be okay with medium cholesterol, but the odds are stacked against you. And with irresponsible Paleo bloggers out there telling you that none of this matters, you probably will never even get your LDL-P checked.
The bottom line is that I am putting my money on the primal ("Paleo") cultures with no heart disease.