Peak Testosterone Forum

General Category => Testosterone, Hormones and General Men's Health => Topic started by: mikeek1111 on May 01, 2020, 07:01:08 pm

Title: Gonadorelin alternative to hCG - Kisspeptin a peptide that is not approved
Post by: mikeek1111 on May 01, 2020, 07:01:08 pm
After doing some digging since a clinic i know is no longer using hCG, a called a few pharmacies and found out they are going to be offering Gonadorelin and NOT Kisspeptin. Kisspeptin is a peptide and it is NOT approved to be compounded and states like California will not approve it, while Gonadorelin is allowed to be compounded. Does anyone have any input on this?
Title: Re: Gonadorelin alternative to hCG - Kisspeptin a peptide that is not approved
Post by: Cataceous on May 01, 2020, 10:02:12 pm
I'll include my reply from over at EM:

Gonadorelin may work (https://www.excelmale.com/forum/threads/pituitary-restart-while-on-trt-promising-initial-results.20864/post-176010) with TRT—producing endogenous LH and FSH—if you add a SERM. But it's not clear if even daily injections would be enough.

Kisspeptin is untested in this capacity, as far as I know. It's an interesting peptide, as its suppression in TRT could be detrimental to us, which may also (https://www.excelmale.com/forum/threads/is-gnrh-suppression-hurting-us.20407/) be the case with gonadorelin/GnRH. For kisspeptin alone to stimulate production of gonadotropins it must first overcome negative feedback at the hypothalamus to produce endogenous GnRH. If this does happen then you still need a SERM to allow the endogenous GnRH to stimulate the pituitary. The hypothalamus has negative feedback from both androgens and estrogens. If we're lucky, all of this negative feedback is upstream of kisspeptin production, so that exogenous kisspeptin would lead to GnRH production. I'm not sure if infrequent injections of kisspeptin would be sufficient for this; it does have a short half-life.

Bottom line: I think you must use a SERM to get either of these possible hCG replacements to do something useful while on TRT. I've shown that gonadorelin is viable, though not necessarily practical. The situation with kisspeptin is less clear.
Title: Re: Gonadorelin alternative to hCG - Kisspeptin a peptide that is not approved
Post by: doin it on February 09, 2021, 02:01:27 am

Interesting

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369329/





Title: Re: Gonadorelin alternative to hCG - Kisspeptin a peptide that is not approved
Post by: Cataceous on February 09, 2021, 02:30:28 am
Thanks for the link. It's nice to get more details about what's going on at the top of the hormonal cascade.

On the general subject of gonadorelin it's worth mentioning that Royal Medical Center (https://www.royalmedicalcenters.com/gonadorelin/) has been conducting some informal research. They say that dose titration has led them to a protocol of injecting either 50 or 100 mcg of gonadorelin twice a week. They claim that these injections produce a subsequent LH pulse of normal amplitude. Not much has been said yet about specific subjective benefits, though they are suggesting results comparable to hCG. I am reserving judgment until there are more reports from guys on this protocol.
Title: Re: Gonadorelin alternative to hCG - Kisspeptin a peptide that is not approved
Post by: doin it on February 09, 2021, 03:05:41 am

The article references Inhibin A in which I am intensely interested.  If anyone has any info on male (only male) disease states involving Inhibin A, I would appreciate the sharing of the info.
Thanks
Title: Re: Gonadorelin alternative to hCG - Kisspeptin a peptide that is not approved
Post by: Oberin on April 06, 2021, 09:21:59 pm
Not sure why Kisspeptin is not approved, I've seen some states where it is. As far as I know, they're used for different things. One solves women issues, like menstruation and the other one is dedicated to 'sex problems if I can call them like that. Anyway, you can always take an alternative to it such as [edited by moderator]. But it's best to talk to a doctor first, it's safer this way. I wouldn't take anything without consulting my doctors first as they have my medical history and of course, they know best.
Title: Re: Gonadorelin alternative to hCG - Kisspeptin a peptide that is not approved
Post by: ghce on April 06, 2021, 10:04:52 pm
. I wouldn't take anything without consulting my doctors first as they have my medical history and of course, they know best.

I wouldn't be relying on the last part of that sentence as it is an exception going on what the consensus is with guys here on TRT or experiencing hormonal related issues and absolutely flies in the face of my own personal experiences with all of the endos and gps I have consulted in the last 6 years.