Peak Testosterone Forum

General Category => Testosterone, Hormones and General Men's Health => Topic started by: Sighalot on April 05, 2015, 06:26:45 am

Title: My Trial With Pregnenolone
Post by: Sighalot on April 05, 2015, 06:26:45 am
2 days ago i started with pregnenolone to see what change it does, dose is currently 50mg a day, i have not felt any positive effects yet but im hoping for a change,

Prior medication is nebido every 6 week, first and second injection had T levels at 14-15 pmol/L 35 days after injection and it was borderline enough for me, got low shbg so both free and bioavailable was decent.

Due to elevated estradiol im also using arimidex at very low dose since im trying to find out how much i actually need so only dosing when i got clear symptoms, last injection was march 11 and so far taken 1.58mg total and im not sure i will even go over 2mg before next injection april 22.

Regards
Sighalot
Title: Re: My Trial With Pregnenolone
Post by: PeakT on April 05, 2015, 05:32:03 pm
2 days ago i started with pregnenolone to see what change it does, dose is currently 50mg a day, i have not felt any positive effects yet but im hoping for a change,

Prior medication is nebido every 6 week, first and second injection had T levels at 14-15 pmol/L 35 days after injection and it was borderline enough for me, got low shbg so both free and bioavailable was decent.

Due to elevated estradiol im also using arimidex at very low dose since im trying to find out how much i actually need so only dosing when i got clear symptoms, last injection was march 11 and so far taken 1.58mg total and im not sure i will even go over 2mg before next injection april 22.

Regards
Sighalot

Good luck.  You might want to split it up into two doses daily?
Title: Re: My Trial With Pregnenolone
Post by: Sighalot on April 06, 2015, 01:23:22 am
One reason why i take one dose in the morning, seems to be a "slow" hormone and also seen 2 users say it worked best when taken in the morning.

Pregnenolone is largely converted into two other "youth-associated" protective hormones, progesterone and DHEA. At the age of 30, both men and women produce roughly 30 to 50 mg. of pregnenolone daily. When taken orally, even in the powdered form, it is absorbed fairly well. One dose of approximately 300 mg (the size of an aspirin tablet) keeps acting for about a week, as absorption continues along the intestine, and as it is "recycled" in the body. Part of this long lasting effect is because it improves the body's ability to produce its own pregnenolone. It tends to improve function of the thyroid and other glands, and this "normalizing" effect on the other glands helps to account for its wide range of beneficial effects.
http://raypeat.com/articles/articles/three-hormones.shtml
Title: Re: My Trial With Pregnenolone
Post by: PeakT on April 06, 2015, 01:32:12 am
One reason why i take one dose in the morning, seems to be a "slow" hormone and also seen 2 users say it worked best when taken in the morning.

Pregnenolone is largely converted into two other "youth-associated" protective hormones, progesterone and DHEA. At the age of 30, both men and women produce roughly 30 to 50 mg. of pregnenolone daily. When taken orally, even in the powdered form, it is absorbed fairly well. One dose of approximately 300 mg (the size of an aspirin tablet) keeps acting for about a week, as absorption continues along the intestine, and as it is "recycled" in the body. Part of this long lasting effect is because it improves the body's ability to produce its own pregnenolone. It tends to improve function of the thyroid and other glands, and this "normalizing" effect on the other glands helps to account for its wide range of beneficial effects.
http://raypeat.com/articles/articles/three-hormones.shtml

So are you a follower of Ray Peat or just happened to come across one of his articles?
Title: Re: My Trial With Pregnenolone
Post by: Sighalot on April 06, 2015, 01:41:08 am
Came across it when i was searching what doses is used with pregnenolone.
Title: Re: My Trial With Pregnenolone
Post by: PeakT on April 06, 2015, 05:52:37 pm
Came across it when i was searching what doses is used with pregnenolone.

Really int'g article from Ray Sahelian.  His dosage is smaller and he has really played with this a lot it sounds like:

http://www.life-enhancement.com/magazine/article/95-exclusive-interview-with-ray-sahelian-md-the-promise-of-pregnenolone
Title: Re: My Trial With Pregnenolone
Post by: tomahawk on April 06, 2015, 10:15:02 pm
thanks for posting this! please give us an update in a few weeks please?

couple of questions, if you take Pregnenolone, does your own "production" suppress or shut down?
guessing... would the body pick up exogenous Preg and therefore Cholesterol levels would raise?
Title: Re: My Trial With Pregnenolone
Post by: tomahawk on April 06, 2015, 10:35:46 pm
from Dr Lam, this is actually for women, but maybe it's similar for men?

"Some with Adrenal Fatigue find pregnenolone replacement improves their energy, vision, memory, clarity of thinking, well being, and often sexual enjoyment or libido. Some women report lessening of hot flashes or premenstrual symptoms and this is likely due to the rise of progesterone (the biological daughter of pregnenolone) reduction in estrogen dominance. Others, however, may find pregnenolone worsen existing fatigue and may even trigger adrenal crashes. Such paradoxical reactions are common. The more advanced the adrenal weakness, the more likely such experiences are common."
Title: Re: My Trial With Pregnenolone
Post by: PeakT on April 06, 2015, 10:40:02 pm
from Dr Lam, this is actually for women, but maybe it's similar for men?

"Some with Adrenal Fatigue find pregnenolone replacement improves their energy, vision, memory, clarity of thinking, well being, and often sexual enjoyment or libido. Some women report lessening of hot flashes or premenstrual symptoms and this is likely due to the rise of progesterone (the biological daughter of pregnenolone) reduction in estrogen dominance. Others, however, may find pregnenolone worsen existing fatigue and may even trigger adrenal crashes. Such paradoxical reactions are common. The more advanced the adrenal weakness, the more likely such experiences are common."

Yes, although I think a lot of the problems are because people take too much of most of the these hormones. I see that on the melatonin side all the time.
Title: Re: My Trial With Pregnenolone
Post by: Sighalot on April 07, 2015, 05:34:55 am
thanks for posting this! please give us an update in a few weeks please?
The idea was to write every now and then how it works and side effects.

Quote
couple of questions, if you take Pregnenolone, does your own "production" suppress or shut down?
guessing... would the body pick up exogenous Preg and therefore Cholesterol levels would raise?
Im using exogenous testosterone and it affects the conversion of cholesterol to pregnenolone, i have planned to visit the gp next month to talk about some blood tests so can include cholesterol.

Really int'g article from Ray Sahelian.  His dosage is smaller and he has really played with this a lot it sounds like:
Half capsule under the tongue will be tested.


Yes, although I think a lot of the problems are because people take too much of most of the these hormones. I see that on the melatonin side all the time.
I saw it alot when i read up on dhea, doses up to 400mg was recommended and used...wonder if i would even survive a dose like that considering how much effect i had with 30mg :O
Title: Re: My Trial With Pregnenolone
Post by: PeakT on April 07, 2015, 06:50:27 am
Did you see that other thread i posted?  No one even know what a physiological level is.
Title: Re: My Trial With Pregnenolone
Post by: Sighalot on April 07, 2015, 01:59:33 pm
.......feels like estradiol is on the rise, will take 1/3 of a pill today too see what happens but its the third dosing since march 31st so its a slight increase but if its pregnenolone i can not say for sure.

Did you see that other thread i posted?  No one even know what a physiological level is.
Thread about adrenal fatigue?

Talked too a women in my country which had pregnenolone prescribed, dose was 100mg for 3 months then lower too 50mg.
Title: Re: My Trial With Pregnenolone
Post by: PeakT on April 07, 2015, 06:33:47 pm
.......feels like estradiol is on the rise, will take 1/3 of a pill today too see what happens but its the third dosing since march 31st so its a slight increase but if its pregnenolone i can not say for sure.

Did you see that other thread i posted?  No one even know what a physiological level is.
Thread about adrenal fatigue?

Talked too a women in my country which had pregnenolone prescribed, dose was 100mg for 3 months then lower too 50mg.

Okay, I wrote a post for this, but I think I forgot to hit send!  Here is the article - I think you'll find it interesting.  I'm gonna make a separate thread now and make sure I hit send.
Title: Re: My Trial With Pregnenolone
Post by: Sighalot on April 08, 2015, 12:16:58 pm
.......feels like estradiol is on the rise, will take 1/3 of a pill today too see what happens but its the third dosing since march 31st so its a slight increase but if its pregnenolone i can not say for sure.
Estradiol it was alright, took 1/3 arimidex yeasterday, when i went to sleep i opened up a ball of tinfoil and dipped my finger in some white powder and rubbed on my gum hopping i got the right amount of melatonin and went to bed, melatonin doses lower then 1mg are not available over here.
Feel asleep in a matter of minutes, sleeped through the night woke up after 6 hours for a visit to the toilet, then i went back to bed half asleep half awake feeling very comfortable for 1 hours then i went up 1 minute before my alarm went off.
Walked out in the kitchen, feeling the sun on my face knowing summer is just around the corner whistling christmas songs with a quite ok morning wood.
Took my bike out for a ride and feeling better then usual, i even noticed the cars before running into them lol but i wonder if 50mg may be on the high side since it noticeably rises estradiol.

May buy me a scale that can measure down to 0.01gram so i can split a capsule into smaller doses.
Title: Re: My Trial With Pregnenolone
Post by: VinnAY on April 08, 2015, 03:32:28 pm
I've been using the Pharm grade I think 30mg for about a month, one in the morning without anything noticeable (along with 10mg DHEA). Something I did do today, different, was do both of those sublingual holding the capsules under my tongue for 5-10 minutes. Didn't taste bad, but need to do that steady to see if that works better for me.
Title: Re: My Trial With Pregnenolone
Post by: Sighalot on April 08, 2015, 03:50:07 pm
Didn't taste bad, but need to do that steady to see if that works better for me.
Tasted a bit like chalk, did it too today.
Title: Re: My Trial With Pregnenolone
Post by: Sighalot on April 09, 2015, 11:09:28 pm
Starting to suspect 50mg is too much, twice now in 3 days i had to use arimidex to push down estradiol, tomorrow im going with half a capsule a day.
Title: Re: My Trial With Pregnenolone
Post by: Sighalot on April 13, 2015, 11:06:42 pm
Suspecting T is getting low, erections not what they used to be and ddint get any real improvement when i used arimidex yeasterday, 5 weeks since last injection next injection is next week :(

Got a year supply of testogel so will use 100mg a day the next couple of days to see what happens, if T is low then i should notice an improvement which indicates its not pregnenolone causing this.
Title: Re: My Trial With Pregnenolone
Post by: PeakT on April 13, 2015, 11:14:02 pm
Suspecting T is getting low, erections not what they used to be and ddint get any real improvement when i used arimidex yeasterday, 5 weeks since last injection next injection is next week :(

Got a year supply of testogel so will use 100mg a day the next couple of days to see what happens, if T is low i should notice an improvement.

You sure you are not too low with estadiol?  That can be an erection killer.
Title: Re: My Trial With Pregnenolone
Post by: Sighalot on April 13, 2015, 11:31:04 pm
Sure i can not be since i have no way of testing it but a couple of weeks before last injection i didnt use arimidex at all and after the injection i only used it when i felt symptoms in an attempt to find lowest dose necessary, last injection was taken march 11 and have used 2.58mg arimidex since then.

Title: Re: My Trial With Pregnenolone
Post by: VinnAY on April 14, 2015, 05:38:26 pm
I simply feel better dissolving the Preg and DHEA capsules under my tongue. Not energized but much more able to get things done around the house, more motivated, more positive outlook. I'm sleeping better at night, too.
Title: Re: My Trial With Pregnenolone
Post by: timmy11 on April 14, 2015, 06:07:18 pm
I simply feel better dissolving the Preg and DHEA capsules under my tongue. Not energized but much more able to get things done around the house, more motivated, more positive outlook. I'm sleeping better at night, too.
[/quote
What brand and/or type do you use? My pregnenonlone was low, Dr is hoping hcg will help that but if not would like to have that in my back pocket!]
Title: Re: My Trial With Pregnenolone
Post by: Sighalot on April 14, 2015, 08:43:21 pm
Got another brand of pregnenolone on the way, dont feel any improvements with testogel :(
Title: Re: My Trial With Pregnenolone
Post by: VinnAY on April 14, 2015, 08:55:04 pm
@Timmy11, I'm using the Pure Encapsulations pharm grade capsules. It takes 5-10 minutes to dissolve then you just rinse down the remains.
Title: Re: My Trial With Pregnenolone
Post by: Sighalot on April 17, 2015, 07:14:58 pm
Sensitivity was increased both yeasterday and today, more to what i would call normal levels.
Been using testogel twice a day, morning and evening.

Its said gels increases DHT, perhaps it is one factor of how stimulation is perceived.
Title: Re: My Trial With Pregnenolone
Post by: Sighalot on April 19, 2015, 06:21:57 pm
Sighs a lot  :( only lasted 2 days, yeasterday it was more like someone had rubbed lidokain all over my penis :/

Sleep is ok, had not had a decent morning erection since i tried dhea, testogel is applied when waking up and after shower, using melatonin prior to sleep and feels like it increases quality a little.
Expect to receive pregnenolone from another manufacture next week, will use testogel 2 more days then stop when i get the next injection with nebido.

As it looks today sensitivity is the main issue, erections are mostly ok to good.
Title: Re: My Trial With Pregnenolone
Post by: Sighalot on April 23, 2015, 04:37:25 pm
Yeasterday i got an injection with nebido and if i dont feel any improvement in the next couple of days i will quit since erections are pretty bad, difficult to get hard, dont last long and go soft very easy  and also fail to notice women in skin tight clothes on the bicycle lane(first week with summer temperatures).

17 hours ago i took 1/3mg arimidex and does not seem to help, have not decided yet if i will take another dose before quitting or not to rule out high estradiol.
Testogel had temporary ok effect then it dropped off to about nothing at all.
Title: Re: My Trial With Pregnenolone
Post by: PeakT on April 23, 2015, 06:49:37 pm
Yeasterday i got an injection with nebido and if i dont feel any improvement in the next couple of days i will quit since erections are pretty bad, difficult to get hard, dont last long and go soft very easy  and also fail to notice women in skin tight clothes on the bicycle lane(first week with summer temperatures).

17 hours ago i took 1/3mg arimidex and does not seem to help, have not decided yet if i will take another dose before quitting or not to rule out high estradiol.
Testogel had temporary ok effect then it dropped off to about nothing at all.

You might want to pull DHEA, DHT and/or thyroid?
Title: Re: My Trial With Pregnenolone
Post by: Sighalot on April 23, 2015, 08:09:34 pm
Have no way of checking dhea and dht due to public health care, expecting a letter with latest tests for tsh and free t4 tomorrow but i seriously doubt they are off since i use 100mcg levothyroxine and 10mcg triiodthyronin a day.

Might add that im feeling grumpy today which have been listed as a symptom of high estradiol  ???

Since there is alot of writing about vitamin D, have taken 100.000 UI the last 2 months, pushed me from 24.4->52nmol/L which is barely in range, below 50 is at risk of deficiency.
Title: Re: My Trial With Pregnenolone
Post by: PeakT on April 23, 2015, 10:16:11 pm
Have no way of checking dhea and dht due to public health care, expecting a letter with latest tests for tsh and free t4 tomorrow but i seriously doubt they are off since i use 100mcg levothyroxine and 10mcg triiodthyronin a day.

Might add that im feeling grumpy today which have been listed as a symptom of high estradiol  ???

Since there is alot of writing about vitamin D, have taken 100.000 UI the last 2 months, pushed me from 24.4->52nmol/L which is barely in range, below 50 is at risk of deficiency.

Have you seen the other cautiionary thread on Vitamin D?  I guess there's a study that says that fertility declines at about 50 or something.
Title: Re: My Trial With Pregnenolone
Post by: Sighalot on April 24, 2015, 09:28:20 pm
Have you seen the other cautiionary thread on Vitamin D?
I read Kierkergard's thread.

Was told today my Tsh is about 0.42, range 0.4-4.2 and target value 0.5-1 so its pretty much spot on where i want it.
Free t3 was not checked, still waiting for result on free T4.

Considering to lower levothyroxine from 100->75mcg and increase triiodthyronine 10->20mcg.
Title: Re: My Trial With Pregnenolone
Post by: PeakT on April 24, 2015, 09:37:50 pm

Considering to lower levothyroxine from 100->75mcg and increase triiodthyronine 10->20mcg.

Let us know if this helps.
Title: Re: My Trial With Pregnenolone
Post by: Sighalot on April 24, 2015, 10:51:01 pm
I will, been alot of changes lately and im not entirely sure what the effects are so i intend to try pregnenolone once more in the future when its stabilized which may take time since i received a couple of new meds today.