Peak Testosterone Forum

General Category => Testosterone, Hormones and General Men's Health => Topic started by: PeakT on June 29, 2015, 03:18:09 pm

Title: POLL: DHEA and Pregnenalone Use
Post by: PeakT on June 29, 2015, 03:18:09 pm
Please include a comment as to

a) how much you are taking

b) transdermal, oral, etc.

c) benefits

d) side effects

e) how long you have been taking it

f) daily?

g) did you get a lab read before you started?
Title: Re: POLL: DHEA and Pregnenalone Use
Post by: seppuku on June 29, 2015, 03:27:32 pm
DHEA - 25mg a day, sublingual,  for about 14 years I think.
Pregnenolone - 10mg-50mg a day, not every day though,  also about 14 years

Benefits - I believe the dhea has had a positive effect on my immune system,  and stress levels.  Similar effects from pregnenolone, I tend to use that more for fatigue though.
Title: Re: POLL: DHEA and Pregnenalone Use
Post by: PeakT on June 29, 2015, 03:30:38 pm
I am currently taking 25 mg (oral) DHEA daily as an experiment.  No sides that I have noticed and I believe it has decreased anxiety.  (I was low.)
Title: Re: POLL: DHEA and Pregnenalone Use
Post by: Sighalot on June 29, 2015, 11:06:19 pm
A. 12mg

B. Sublingual

C. Reduces side effects from nebido like weak erections, lower libido and lack of penile sensitivity

D. No side effects with sublingual however got severe side effects from dhea, possibly excessive conversion into estrogens

E. 1 week and will keep taking 12mg a day for several weeks more before i make any changes like adding pregnenolone.

F. Every morning, if i go up to 25mg i might go for 12mg twice a day.

G. No labs done since endo calls this "hocus pocus"
Title: Re: POLL: DHEA and Pregnenalone Use
Post by: Cataceous on June 30, 2015, 02:26:27 am
a) DHEA 12.5 mg x 2

b) oral

c) benefits indeterminate

d) no obvious side effects

e) taken for a month so far

f) two half-tablets, one morning, one evening

g) 3 lab results showed near bottom of scale
Title: Re: POLL: DHEA and Pregnenalone Use
Post by: PeakT on July 01, 2015, 02:43:39 pm
Bump...
Title: Re: POLL: DHEA and Pregnenalone Use
Post by: JustAskin on July 07, 2015, 04:25:16 pm
A:  DHEA  25mg.   (pure encapsulations) mornings   (Dr. Shippen put me on this)
B:  Oral
C:  Benefits, Sleep better, feel better and clear head.
D:  Side affects  None
E:  Daily
F:  Taking for 3 years
G:  I got labs before and I was at 123, and have gotten labs every 6 months, now I stay around 350.
I also take 25mg. Pregnenolone daily, before my lab was 40, now it stays around 180, it also keeps my Progesterone at 110
Title: Re: POLL: DHEA and Pregnenalone Use
Post by: PeakT on July 07, 2015, 06:49:44 pm
A:  DHEA  25mg.   (pure encapsulations) mornings   (Dr. Shippen put me on this)
B:  Oral
C:  Benefits, Sleep better, feel better and clear head.
D:  Side affects  None
E:  Daily
F:  Taking for 3 years
G:  I got labs before and I was at 123, and have gotten labs every 6 months, now I stay around 350.
I also take 25mg. Pregnenolone daily, before my lab was 40, now it stays around 180, it also keeps my Progesterone at 110

So do you know what range he was targetting?  LEF likes 350-500 DHEAS levels for most from what I understand.

So DHEA boost progesterone typically or just in you?
Title: Re: POLL: DHEA and Pregnenalone Use
Post by: PeakT on July 07, 2015, 06:51:44 pm
UPDATE:  I found my lab results and my DHEAS prior to supplementation was 108 mcg/dl.  That's pretty low - I don't think too many men get down this low.  So, yeah, I'm special...
Title: Re: POLL: DHEA and Pregnenalone Use
Post by: Cataceous on July 07, 2015, 07:50:27 pm
UPDATE:  I found my lab results and my DHEAS prior to supplementation was 108 mcg/dl.  That's pretty low - I don't think too many men get down this low.  So, yeah, I'm special...
Can we both be special? My two blood results were 102.7 and 87.2 mcg/dl. Next week I'll see if supplementing has helped.
Title: Re: POLL: DHEA and Pregnenalone Use
Post by: JustAskin on July 07, 2015, 08:27:53 pm
Dr. Shippen likes 300-450.
No DHEA did not raise Progesterone,  Pregnenolone will raise Progesterone.
I also take 25mg. Pregnenolone daily, before my lab was 40, now it stays around 180, it also keeps my Progesterone at 110
Title: Re: POLL: DHEA and Pregnenalone Use
Post by: explorer on July 07, 2015, 08:30:14 pm
No DHEA did not raise Progesterone,  Pregnenolone will raise Progesterone.

I wonder if taking DHEA frees up pregnenolone to make progesterone, because DHEA is also made of pregnenolone.
Title: Re: POLL: DHEA and Pregnenalone Use
Post by: fun2drive on July 07, 2015, 08:56:05 pm
25mg as an experiment orally

2nd day of use

Nothing to report to date

Labs taken last week so current information for comparison in a month
Title: Re: POLL: DHEA and Pregnenalone Use
Post by: PeakT on July 07, 2015, 09:02:49 pm
Dr. Shippen likes 300-450.
No DHEA did not raise Progesterone,  Pregnenolone will raise Progesterone.
I also take 25mg. Pregnenolone daily, before my lab was 40, now it stays around 180, it also keeps my Progesterone at 110

Noted.  Did you get any rise in cortisol do you know?

What I like about Kurzweil is his optimism.  Kind of hard to find people that are jaded...
Title: Re: POLL: DHEA and Pregnenalone Use
Post by: timmy11 on July 07, 2015, 09:57:53 pm
Just started 50mg of pregnenolone oral pill. Trying to raise progesterone which was at 0.4. I am tapering off clonazepam and want to get my progesterone up before further tapering.  Hcg did not raise my progesterone at all! Benzo tapering sucks!! Any advice on above material welcomed!!
Title: Re: POLL: DHEA and Pregnenalone Use
Post by: PeakT on July 08, 2015, 04:02:07 pm
Anyone else?
Title: Re: POLL: DHEA and Pregnenalone Use
Post by: ThyroidPatient on July 08, 2015, 11:19:32 pm
I voted for just Pregnenolone use. 

I have hashimoto's and low testosterone like many others on this board.  I'm on 125mcg Levoxyl, 4mg Slow Release compounded T3, 60mg T-Cypionate E3.5days, 500IU hCG 3x week & .25mg Arimidex within 24 hours of each test shot.  Stats:  39yo, 6'0", 210lbs.  Somewhere around 15-17% body fat.  I like to lift weights.  I feel really good lately.  Everything is working properly finally after a year.

I've been lurking for a little while and reading up on everything for the past year and this forum and the two other big ones have been very educational.

My endo (Dr. Arem if anyone's heard of him) gave me an ATCH stim test and diagnosed me with borderline adrenal insufficiency.  I then had blood work done from LabCorp and my Pregnenolone was 16 ng/dL with the range being <151.  I showed that lab to my endo and I said it seems low but I have absolutely no basis for that opinion.  I asked about supplementing it but didn't really know if it would make a difference (which is also the majority opinion on the internet).  He suggested I keep it clean and not use it because no one really knows about long term side effects. 

I ended up starting 50mg tablet every night with my other vitamins about 3 months ago.  I've since had a 4 tube saliva cortisol test and a blood progesterone test.  Cortisol was at the top for all 4 time periods and Progesterone came back in the upper 1/4 of the range.  I can't say I've noticed any side effects or benefits and I can't prove it's actually doing anything.  There's at least 5 possibilities or some combination of these:

1.  ATCH stim test was wrong.
2.  Cortisol saliva test was wrong.
3.  Pregenenolone is actually working.
4.  My hCG I was on was stale at the time of the ATCH stim test. 
5.  My diet is more plant and fish based (lots of salads and salmon now) and I've been a bit more aggressive working out since I've recovered from my snowboarding injury this past winter.
Title: Re: POLL: DHEA and Pregnenalone Use
Post by: PeakT on July 09, 2015, 05:18:30 am
My two cents:  pregnenalone works best on the brain and guys feel better often mentally.  And sometimes will raise hormones.  But it seems very unpredictable as far as what it will do in the case of the latter. 
Title: Re: POLL: DHEA and Pregnenalone Use
Post by: ATXHawk on July 09, 2015, 11:19:32 pm
Will be starting a DHEA and Pregnenalone regimen tomorrow. 25mg of each, will report back.
Title: Re: POLL: DHEA and Pregnenalone Use
Post by: PeakT on July 10, 2015, 03:48:11 am
Will be starting a DHEA and Pregnenalone regimen tomorrow. 25mg of each, will report back.

Remember to measure yourself first and make sure you are low if you haven't.
Title: Re: POLL: DHEA and Pregnenalone Use
Post by: Cronos on July 10, 2015, 03:31:17 pm
Back up to 50 mg of DHEA a day. Oral kind instead of sublingual and feel great!
Title: Re: POLL: DHEA and Pregnenalone Use
Post by: PeakT on July 10, 2015, 06:27:45 pm
Back up to 50 mg of DHEA a day. Oral kind instead of sublingual and feel great!

Nice.  So let me guess:  anxiety levels are done and you feel more peaceful?
Title: Re: POLL: DHEA and Pregnenalone Use
Post by: Cronos on July 10, 2015, 06:44:22 pm
Back up to 50 mg of DHEA a day. Oral kind instead of sublingual and feel great!

Nice.  So let me guess:  anxiety levels are done and you feel more peaceful?

Yes. Anxiety has dropped. Libido is back up. Erectile function back up. I feel quite a bit like I did when I first started the HCG/DHEA combo. Except now I'm just on the DHEA
Title: Re: POLL: DHEA and Pregnenalone Use
Post by: PeakT on July 10, 2015, 08:28:33 pm

Yes. Anxiety has dropped. Libido is back up. Erectile function back up. I feel quite a bit like I did when I first started the HCG/DHEA combo. Except now I'm just on the DHEA

Yeah, I'm feeling very good myself.  Now imo you should keep the 50 mg going for a bit and then taper back to 25 mg and see if that will work for you, i.e. play around with dosage.  I'm double your age and doing good with 25 mg for example.
Title: Re: POLL: DHEA and Pregnenalone Use
Post by: Cronos on July 11, 2015, 03:50:25 pm

Yes. Anxiety has dropped. Libido is back up. Erectile function back up. I feel quite a bit like I did when I first started the HCG/DHEA combo. Except now I'm just on the DHEA

Yeah, I'm feeling very good myself.  Now imo you should keep the 50 mg going for a bit and then taper back to 25 mg and see if that will work for you, i.e. play around with dosage.  I'm double your age and doing good with 25 mg for example.

I've done that already. Barely budged my DHEA levels and I felt like garbage. 25 mg only got my levels up around 220
Title: Re: POLL: DHEA and Pregnenalone Use
Post by: PeakT on July 11, 2015, 05:45:11 pm

Yes. Anxiety has dropped. Libido is back up. Erectile function back up. I feel quite a bit like I did when I first started the HCG/DHEA combo. Except now I'm just on the DHEA

Yeah, I'm feeling very good myself.  Now imo you should keep the 50 mg going for a bit and then taper back to 25 mg and see if that will work for you, i.e. play around with dosage.  I'm double your age and doing good with 25 mg for example.

I've done that already. Barely budged my DHEA levels and I felt like garbage. 25 mg only got my levels up around 220

Understood.  LEF says 15-50 will do usually it and you are obviously on the upper end.. 
Title: Re: POLL: DHEA and Pregnenalone Use
Post by: Sighalot on July 12, 2015, 08:09:42 pm
Im up on 25mg sublingual every morning since a couple of days and feel a slight improvement but to early to tell if its dhea or not but no side effects at least.
Title: Re: POLL: DHEA and Pregnenalone Use
Post by: PeakT on July 12, 2015, 08:12:36 pm
Im up on 25mg sublingual every morning since a couple of days and feel a slight improvement but to early to tell if its dhea or not but no side effects at least.

Better to start on the low side if you ask me...
Title: Re: POLL: DHEA and Pregnenalone Use
Post by: PeakT on August 02, 2015, 07:41:34 am
Bump...
Title: Re: POLL: DHEA and Pregnenalone Use
Post by: Tropicaldaze on August 05, 2015, 09:22:25 pm
Thrid week on pregnenolone.  Started at 500mg daily, mixed in some olive oil, (Came to that dose per my reading and feedback on Ray Peat Forum, and as I've said, I'm a mad scientist!).  It definitely broke my long standing depression after three weeks.  Also has raised my libido but only slight improvement in erectile function.  My wife and I were making out.(A perfectly good term, lol)and I did get a good, strong erection but I didn't make it to the finals...sigh.  We had a good time and I still left her with a smile on her face.  No further comments. 8)

I was thinking about adding transdermal DHEA, 10 to 20mg in order to avoid excessive E2 conversion, which happened when I did 25mg oral a couple of years ago.  But DHEA, as I've previously written, had a most positive effect on libido and erectile function, as well as mood.
Title: Re: POLL: DHEA and Pregnenalone Use
Post by: PeakT on August 06, 2015, 03:36:03 am
Thrid week on pregnenolone.  Started at 500mg daily, mixed in some olive oil, (Came to that dose per my reading and feedback on Ray Peat Forum, and as I've said, I'm a mad scientist!).  It definitely broke my long standing depression after three weeks.  Also has raised my libido but only slight improvement in erectile function.  My wife and I were making out.(A perfectly good term, lol)and I did get a good, strong erection but I didn't make it to the finals...sigh.  We had a good time and I still left her with a smile on her face.  No further comments. 8)

I was thinking about adding transdermal DHEA, 10 to 20mg in order to avoid excessive E2 conversion, which happened when I did 25mg oral a couple of years ago.  But DHEA, as I've previously written, had a most positive effect on libido and erectile function, as well as mood.

500 mg?!?  Wow.  Can you show me the links that advise that?

We just had a guy on here that jacked up his progesterone supraphysiological, which slammed his DHT down and he seemed stuck in that state.
Title: Re: POLL: DHEA and Pregnenalone Use
Post by: Tropicaldaze on August 08, 2015, 03:52:05 pm
Peak,

This is from the site Ray Peat Forum.  Though this isn't an abstract or direct quote from Ray Peat, the poster states that he has used high doses of preg and states that RP also used high doses for several years to reverse long standing health problems related to poor metabolic function, since RP is an endocrine physiologist who uses himself as a test subject.

I truly feel better, mood wise, than I have in many years.  Between Testopel and preg, my libido is closer to what it was in my 20s and there has been a small improvement in erectile function though I've got a way to go.  I'm certainly not advocating my approach to anyone else, but HPTA axis malfunction is an established fact in bipolar illness and poor mitochondrial function is also implicated. The aforementioned problems need to be dealt with and preg, IMO, is the perfect pro hormone to begin my physical and psychiatric restoration.  I'll search RP Forum for a direct quote from Ray Peat stating that pregnenolone, alone, can restore function and balance to the entire endocrine system.


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Contact haidut

Pregnenolone likely effective for schizophrenia

 Postby haidut Mon Feb 17, 2014 2:30 am

I have been following this for some time now. The pharma industry is quickly running out of options for managing drug-resistant schizophrenia so it is turning to therapies from the beginning of the 20th century. Either way, if this makes it through the clinical trials it would be a huge win for Ray's ideas but bad news for us b/c I can guarantee you that pregnenolone's status as a dietary supplement will end the moment FDA realizes it works for a variety of "untreatable" brain conditions including all types of dementia (hint: AD) and psychiatric diseases.

http://www.sciencedirect.com/science/ar ... 0786X?np=y
http://www.ncbi.nlm.nih.gov/pubmed/24496044
http://www.ncbi.nlm.nih.gov/pubmed/23240026

The human studies used pregnenolone as adjunctive therapy and saw very positive results with the low dose of 50mg/day. The last study is a rodent study and used only pregnenolone, and it completely stopped the diseases. The human dosage equivalent from that study is 400mg-500mg per day. Though high, it is considered quite safe. Ray has taken 1g for extended period of time with no complaints and I have gone even higher with no side effects. The study I posted on pregnenolone's stimulatory effect on the thyroid used a human dose equivalent of 2.5g per day.
Title: Re: POLL: DHEA and Pregnenalone Use
Post by: PeakT on August 08, 2015, 07:17:35 pm
Just started 50mg of pregnenolone oral pill. Trying to raise progesterone which was at 0.4. I am tapering off clonazepam and want to get my progesterone up before further tapering.  Hcg did not raise my progesterone at all! Benzo tapering sucks!! Any advice on above material welcomed!!

I'd start lower and I'd measure yourself first including progesterone.
Title: Re: POLL: DHEA and Pregnenalone Use
Post by: PeakT on October 15, 2015, 12:47:56 pm
Bump...

Trying to get new members to vote.
Title: Re: POLL: DHEA and Pregnenalone Use
Post by: PeakT on January 19, 2016, 05:25:26 pm
Bump...
Title: Re: POLL: DHEA and Pregnenalone Use
Post by: Torrential on January 20, 2016, 02:31:47 pm
500mg of preg is more than I've even heard of anyone using. However, oral is poorly adsorbed so maybe the net effective dose is more reasonable.

I take DHEA, 25mg oral morning and evening. I started with one pill, got a nice bump in DHEA-S, and added a second pill at my dr's suggestion. FWIW, I use preg only rarely these days and only sublingual. The Source Naturals brand has worked very well for me in the 10mg and 25mg dosages.
Title: Re: POLL: DHEA and Pregnenalone Use
Post by: PeakT on January 20, 2016, 03:36:03 pm
500mg of preg is more than I've even heard of anyone using. However, oral is poorly adsorbed so maybe the net effective dose is more reasonable.

I take DHEA, 25mg oral morning and evening. I started with one pill, got a nice bump in DHEA-S, and added a second pill at my dr's suggestion. FWIW, I use preg only rarely these days and only sublingual. The Source Naturals brand has worked very well for me in the 10mg and 25mg dosages.

Why did you stop using pregnenalone?

And, yes, I agree that 500 mg is way too much.
Title: Re: POLL: DHEA and Pregnenalone Use
Post by: Sighalot on January 20, 2016, 04:24:47 pm
500mg of preg is more than I've even heard of anyone using.
Ray Peat have tried 1500mg.
Quote
However, oral is poorly adsorbed so maybe the net effective dose is more reasonable.
Thats the reason why i went over to sublingual, i needed ~200mg to feel a difference but with sublingual it was enough with 6mg and even that may have been to much.

Title: Re: POLL: DHEA and Pregnenalone Use
Post by: PeakT on January 20, 2016, 05:01:19 pm
500mg of preg is more than I've even heard of anyone using.
Ray Peat have tried 1500mg.
Quote
However, oral is poorly adsorbed so maybe the net effective dose is more reasonable.
Thats the reason why i went over to sublingual, i needed ~200mg to feel a difference but with sublingual it was enough with 6mg and even that may have been to much.

Okay, but we have now had two guys go supraphysiological in progesterone with about a fifth of the dosage that you took.  And they did not do well by the way with the high progesterone as you might expect. 
Title: Re: POLL: DHEA and Pregnenalone Use
Post by: Joe Sixpack on January 25, 2016, 01:12:40 am
I take both
Please include a comment as to

a) how much you are taking
    25 MG DHEA Oral/day.  12MG Preg Sublingual drops/day

c) benefits - None Noted

d) side effects - None Noted

e) how long you have been taking it:  4 months

g) did you get a lab read before you started? 
Preg was 32 at start,
DHEA 93 at start. 
Had a follow up lab of DHEA at 3 months, when it was measured at 129
Title: Re: POLL: DHEA and Pregnenalone Use
Post by: PeakT on January 25, 2016, 03:40:49 am
I'm assuming you meant DHEAS and I'm surprised I didn't bump you up higher
Title: Re: POLL: DHEA and Pregnenalone Use
Post by: Joe Sixpack on January 25, 2016, 04:11:48 am
I'm assuming you meant DHEAS and I'm surprised I didn't bump you up higher
Yes I did mean DHEA-S.  Lazy typing.  I am disappointed by the lack of progress on that as well.   I'm thinking I want to jack it up to 50MG.  Or change to sublingual DHEA.  The sublingual pregnenalone worked pretty well for me. 
Title: Re: POLL: DHEA and Pregnenalone Use
Post by: PeakT on January 25, 2016, 04:39:37 am
I'm assuming you meant DHEAS and I'm surprised I didn't bump you up higher
Yes I did mean DHEA-S.  Lazy typing.  I am disappointed by the lack of progress on that as well.   I'm thinking I want to jack it up to 50MG.  Or change to sublingual DHEA.  The sublingual pregnenalone worked pretty well for me.

25 mg was supposed to triple min roughly.  I am going to do some measurements here and so we will see what happens.
Title: Re: POLL: DHEA and Pregnenalone Use
Post by: Joe Sixpack on January 26, 2016, 01:26:19 am
I'm assuming you meant DHEAS and I'm surprised I didn't bump you up higher
Yes I did mean DHEA-S.  Lazy typing.  I am disappointed by the lack of progress on that as well.   I'm thinking I want to jack it up to 50MG.  Or change to sublingual DHEA.  The sublingual pregnenalone worked pretty well for me.

25 mg was supposed to triple min roughly.  I am going to do some measurements here and so we will see what happens.

Let us know what you find out.  25 MG didn't do much for me.  It's possible that my brand of DHEA is just not any good.  I am using Country Life brand. 
Title: Re: POLL: DHEA and Pregnenalone Use
Post by: PeakT on January 26, 2016, 03:05:12 am

Let us know what you find out.  25 MG didn't do much for me.  It's possible that my brand of DHEA is just not any good.  I am using Country Life brand.

Dr. Saya said that that is a big advantage that you get with compounded DHEA/preg.  He said the brands just don't work that well often (for reasons unknown).
Title: Re: POLL: DHEA and Pregnenalone Use
Post by: Joe Sixpack on January 28, 2016, 02:40:55 am
I just got some new labs back today.  I was still taking 25MG of Country Life DHEA at the time of the blood draw. 

New DHEA-S figure = 296 (range 38-313) 

I guess this brand works after all. 
Title: Re: POLL: DHEA and Pregnenalone Use
Post by: PeakT on February 27, 2016, 04:12:39 pm
I am doing a page on this subject and so, if you haven't voted, can you answer this poll?
Title: Re: POLL: DHEA and Pregnenalone Use
Post by: PeakT on February 28, 2016, 05:02:20 pm
Bump...
Title: Re: POLL: DHEA and Pregnenalone Use
Post by: electrify on February 28, 2016, 07:25:14 pm
I think Pregnenolone may have helped me get out of the post exam derealization I was experiencing. I had a ridiculous stress reaction remember.

I can't be totally sure it was that and not just body recuperating with time (and also higher fat diet for more cholesterol) but I think it couldv'e sped it up. I also had tests done showing that my pregnenolone had dropped a bit due to the stressor.

So I do use it but its more of an on/off thing not persistently. If I were to do TRT again then I would have to use it consistently
Title: Re: POLL: DHEA and Pregnenalone Use
Post by: Sighalot on February 28, 2016, 10:30:18 pm
I quit when i started with hcg but thinking of maybe trying preg+dhea sometimes during the spring.
Title: Re: POLL: DHEA and Pregnenalone Use
Post by: PeakT on January 23, 2017, 06:39:12 am
I split out a partial cure of bipolar disorder with pregnenolone:

http://www.peaktestosterone.com/forum/index.php?topic=11916.0