Peak Testosterone Forum

General Category => Testosterone, Hormones and General Men's Health => Topic started by: PeakT on August 14, 2015, 05:13:10 pm

Title: When Will Androxal Be Available?
Post by: PeakT on August 14, 2015, 05:13:10 pm
Here is my best guess:

http://www.peaktestosterone.com/Androxal_When_FDA_Approval

(For those who don't know, Androxal is the new "Clomid" with just enclomphine, which should produce much better results for the guys who respond well to Clomid.)
Title: Re: When Will Androxal Be Available?
Post by: electrify on August 14, 2015, 05:25:06 pm
Doubt it but if it does come out next month according to your optimistic prediction that would be amazing for me.
Title: Re: When Will Androxal Be Available?
Post by: PeakT on August 14, 2015, 05:28:27 pm
Doubt it but if it does come out next month according to your optimistic prediction that would be amazing for me.

Me too.  But my crystal ball is a little dusty...
Title: Re: When Will Androxal Be Available?
Post by: Nocturne on August 14, 2015, 06:02:20 pm
Doubt it but if it does come out next month according to your optimistic prediction that would be amazing for me.

Me too.  There has to be something to the fact that both when I first went on Clomid and again when I doubled my original dose, I felt great and had almost complete remission of ED for about a week before losing those gains.  Was the loss due to zuclomiphine?  Would be worth finding out.
Title: Re: When Will Androxal Be Available?
Post by: OS on August 14, 2015, 06:11:52 pm
Is it anticipated that Androxal might be used in conjunction with topical/injected testosterone, as a way to combat testicular shrinkage, or any other reason?   Would it be effective for that?  Or will Androxal be a stand-alone therapy?
Title: Re: When Will Androxal Be Available?
Post by: PeakT on August 14, 2015, 06:18:10 pm
Is it anticipated that Androxal might be used in conjunction with topical/injected testosterone, as a way to combat testicular shrinkage, or any other reason?   Would it be effective for that?  Or will Androxal be a stand-alone therapy?

I don't think so.  For example, no one really uses Clomid with TRT.  The goals of the two imo are directly opposing each other. 
Title: Re: When Will Androxal Be Available?
Post by: electrify on August 14, 2015, 11:56:13 pm
Hopefully androxal isn't like Nolvadex either where blocking E2 negates the effects of the increased T. I literally feel nothing on Nolvadex and maybe even somewhat worse on it than before starting.

At least Androxal has a shorter half life so the molecule won't just sit there in the brain for long periods blocking E2 recptors in the brain. On the other hand Nolvadex would tend to accumulate in the brain with each dose.
Title: Re: When Will Androxal Be Available?
Post by: PeakT on August 15, 2015, 05:43:25 am
Hopefully androxal isn't like Nolvadex either where blocking E2 negates the effects of the increased T. I literally feel nothing on Nolvadex and maybe even somewhat worse on it than before starting.

At least Androxal has a shorter half life so the molecule won't just sit there in the brain for long periods blocking E2 recptors in the brain. On the other hand Nolvadex would tend to accumulate in the brain with each dose.

Yeah, I'm super curious about a lot of things with Androxal.  I'm wondering if some guys will feel a lot better on it since it's keeping the pituitary and hypothalamus in the loop.  And I'm wondering, though, if it will really boost testosterone that much as you may know from one of my pages.
Title: Re: When Will Androxal Be Available?
Post by: Nocturne on August 15, 2015, 01:38:42 pm
I could swear I recently saw a study that showed enclomiphene (Androxal) raising T more than Clomid did in monkeys.  IIRC it performed better than a gel too.  I'll look for it.

Also, if you've been on Clomid, an important factor might be FEELING better due to the removal of zuclomiphene from the equation.  If I could feel as good on Androxal long-term as I felt for my first week or so on Clomid (and again after doubling my dose), I'd have my preferred treatment right there with no reason to look anywhere else.  Of course that hinges on the loss of effectivity after the first week or so being due to the effects of zuclomiphene somehow...  But I'd be pushing my doc to switch me over right now if Androxal were available.
Title: Re: When Will Androxal Be Available?
Post by: PeakT on August 15, 2015, 03:11:08 pm
I could swear I recently saw a study that showed enclomiphene (Androxal) raising T more than Clomid did in monkeys.  IIRC it performed better than a gel too.  I'll look for it.

Also, if you've been on Clomid, an important factor might be FEELING better due to the removal of zuclomiphene from the equation.  If I could feel as good on Androxal long-term as I felt for my first week or so on Clomid (and again after doubling my dose), I'd have my preferred treatment right there with no reason to look anywhere else.  Of course that hinges on the loss of effectivity after the first week or so being due to the effects of zuclomiphene somehow...  But I'd be pushing my doc to switch me over right now if Androxal were available.

Sure.  A lot of guys feel that way.  Let me know if you run across that study.
Title: Re: When Will Androxal Be Available?
Post by: xrayguy on August 15, 2015, 03:29:26 pm
Interesting that Androxal is actually being marketed as a treatment for male hypogonadism. This would be good news for us in Canada because other drugs are for use in women only and are considered "off label" for men, and therefore are not used here.

I just found this info FYI:

THE WOODLANDS, Texas, June 8, 2015 (GLOBE NEWSWIRE) -- Repros Therapeutics Inc.(Nasdaq:RPRX) today announced that the Division of Bone, Reproductive and Urologic Products of the U.S. Food and Drug Administration (FDA) has scheduled the advisory committee to review the Company's New Drug Application (NDA) for its enclomiphene product candidate, formerly known as Androxal, on November 3, 2015. The Company submitted the NDA on January 30, 2015. The FDA accepted the NDA for review on April 1, 2015 and later assigned a Prescription Drug User Fee Act (PDUFA) goal date of November 30, 2015.
Title: Re: When Will Androxal Be Available?
Post by: Nocturne on August 15, 2015, 06:25:03 pm
How long after the PDUFA date would we be able to expect it to become available at local pharmacies?
Title: Re: When Will Androxal Be Available?
Post by: electrify on August 15, 2015, 07:52:39 pm
I'm sure it will raise T quite a bit provided you are young....
Title: Re: When Will Androxal Be Available?
Post by: PeakT on August 15, 2015, 11:14:16 pm
How long after the PDUFA date would we be able to expect it to become available at local pharmacies?

I believe it will go to market pretty rapidly - within a few months - but it could be under post-market surveillance.  I'm not sure how much that affects availability.  I've got a relative I can ask.  Will ask about that and let you know what he says...
Title: Re: When Will Androxal Be Available?
Post by: DKC24 on August 16, 2015, 03:37:48 am
what is the difference between this and clomid? less side effects?
Title: Re: When Will Androxal Be Available?
Post by: PeakT on August 16, 2015, 05:00:52 pm
what is the difference between this and clomid? less side effects?

Should be...