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Messages - Cataceous

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1
Testosterone, Hormones and General Men's Health / Re: For guys who had a poor reaction to HCG...
« on: July 16, 2019, 06:26:59 pm »
Quote from: Flyingfool on July 16, 2019, 04:59:43 pm
Quote from: Cataceous on July 16, 2019, 10:32:36 am
...
It's not a dopamine agonist, but PT-141 was recently approved by the FDA for treating low libido in women.

This is of interest to ME. Not so sure for my wife.

TRT has done nothing so far for her libido. Although her free T has not come up past the ministry threshold they list for women.  And part of my wife's issue with libido may be more mental than physiological.  If the driver doesn’t really want to drive to a destination, it doesn’t matter how much fuel is in the tank! 

What is PT-141?

Bremelanotide

FDA approves new treatment for hypoactive sexual desire disorder in premenopausal women

Quote
The U.S. Food and Drug Administration today approved Vyleesi (bremelanotide) to treat acquired, generalized hypoactive sexual desire disorder (HSDD) in premenopausal women.
...
Vyleesi activates melanocortin receptors, but the mechanism by which it improves sexual desire and related distress is unknown. Patients inject Vyleesi under the skin of the abdomen or thigh at least 45 minutes before anticipated sexual activity and may decide the optimal time to use Vyleesi based on how they experience the duration of benefit and any side effects, such as nausea. Patients should not use more than one dose within 24 hours or more than eight doses per month. Patients should discontinue treatment after eight weeks if they do not report an improvement in sexual desire and associated distress.
...

It works for guys too.

2
Testosterone, Hormones and General Men's Health / Re: For guys who had a poor reaction to HCG...
« on: July 16, 2019, 10:32:36 am »
Quote from: Flyingfool on July 16, 2019, 09:40:13 am
Quote from: kregger on July 16, 2019, 12:24:43 am
Dopamine Agonists have reportedly caused hyper sexuality (hyper libido). Apparently they suppress prolactin.

Where can I get dopamine antagonist for my wife who has like zero libido???

It's not a dopamine agonist, but PT-141 was recently approved by the FDA for treating low libido in women.

3
Testosterone, Hormones and General Men's Health / Re: possible to lower high SHBG and increase Free Testosterone by gaining weight?
« on: July 15, 2019, 05:30:29 pm »
The local article doesn't mention gaining weight per se, but it does mention some dietary correlations, including the possibility that "increasing protein intake can lower SHBG."

4
Testosterone, Hormones and General Men's Health / Re: Hcg to help sleep and anxiousness??
« on: July 14, 2019, 11:59:08 am »
Quote from: Flyingfool on July 14, 2019, 08:40:43 am
What age threshold is considered “younger” and “older”?

The link is here. "Younger" means a mean age of 34 year, "older" means a mean age of 74 years.

5
Testosterone, Hormones and General Men's Health / Re: Why is lack of libido so prominent on TRT?
« on: July 14, 2019, 05:17:22 am »
In addition to raising DHT as ghce suggests, have you tried all of the following?

• Test serum progesterone and supplement if low.

• Use a protocol that gives a significant diurnal variation in serum testosterone, such as a 50% drop from peak to trough. This is not necessarily easy, as transdermal testosterone won't create large swings for everyone, and excess DHT is a problem for some. A combination of a testosterone ester and pure testosterone may be injected daily, but it's not something everyone could stay with.

• Experiment with PT-141.

6
Testosterone, Hormones and General Men's Health / Re: Might give the PeakT restart protocol a Shot.
« on: July 14, 2019, 04:50:40 am »
Quote from: StephCurryFtw on July 14, 2019, 03:17:42 am
The Meaning of SERM?  ...

Selective estrogen receptor modulator. A class of drugs that includes clomiphene/Clomid and tamoxifen/Novaldex.

7
Testosterone, Hormones and General Men's Health / Re: Hcg to help sleep and anxiousness??
« on: July 13, 2019, 06:00:27 pm »
One study found that in younger men hCG stimulates progesterone production. The result was not seen in older men.

8
Testosterone, Hormones and General Men's Health / Re: Might give the PeakT restart protocol a Shot.
« on: July 11, 2019, 05:47:24 pm »
Some restart protocols discussed here: https://www.peaktestosterone.com/Testosterone_Restart.aspx

Generally you start with hCG to stimulate the testes, then switch to a SERM. Using hCG with a SERM is questionable, as hCG is suppressive and may override the stimulation of the SERM.

9
Testosterone, Hormones and General Men's Health / Re: cortisol/prednisone/aldosterone/DHEA/adreanals
« on: July 11, 2019, 05:41:52 pm »
Quote from: HRT Guru on July 11, 2019, 11:03:34 am
How would one treat Aldosterone? (rhetorical). ...

Fludrocortisone, brand name Florinef.

10
Testosterone, Hormones and General Men's Health / Re: Thyroid issues or more complex?
« on: July 10, 2019, 07:47:29 pm »
The Tru-T free testosterone calculator yields a value of 11 ng/dL. This is with a normal range of 16-31 ng/dL. Therefore low testosterone does seem to be the most pressing issue.

11
Testosterone, Hormones and General Men's Health / Re: how much actual sodium in Bac Water?
« on: July 10, 2019, 05:54:09 pm »
Quote from: Mr.L on July 10, 2019, 11:15:35 am
Quote from: Cataceous on July 10, 2019, 07:10:34 am
It is 0.9% benzyl alcohol and water. No sodium in the versions that I've seen/read about.

Do you know how long the vial is safe to use? ...

Unopened it would be at least as long as the date given, and probably a good bit longer, though I wouldn't go nearly as long with water-based stuff as I might with oil-based. I keep these vials refrigerated, especially after using them, and have probably pushed things by continuing to use them for a few more months, but without incident. Official instructions probably say either to use immediately, or possibly to refrigerate and use in less than a month.

12
Testosterone, Hormones and General Men's Health / Re: Had enough of Sustanon x2 weekly want try NEBIDO
« on: July 10, 2019, 07:39:31 am »
Aside from testosterone undecanoate, Nebido contains benzyl benzoate and castor oil.

Note that a 4 mL vial contains a total of 1,000 mg testosterone undecanoate. This is on the light side for 12 weeks. The dose is equivalent to 90 mg testosterone cypionate per week, which would be fine for some, but not for others.

As long as sterile storage is possible, there's no reason that one couldn't injection smaller doses more often. Wikipedia puts the half-life at about a month, so it's hard to see how guys do well with one injection every three months, In theory serum testosterone could drop up to eight-fold over that period.

Serum testosterone levels achieved with Nebido will be very individual, and based on factors such as SHBG, body weight, metabolism, etc.

13
Testosterone, Hormones and General Men's Health / Re: how much actual sodium in Bac Water?
« on: July 10, 2019, 07:10:34 am »
It is 0.9% benzyl alcohol and water. No sodium in the versions that I've seen/read about.

14
Testosterone, Hormones and General Men's Health / Re: New to the Site: Intro and Stats
« on: July 09, 2019, 07:40:30 am »
Do retest prolactin. It is capable of suppressing testosterone production on its own. However, although yours was elevated, I don't think it was high enough to suggest high risk for a pituitary tumor, or to cause so much testosterone suppression.
https://www.peaktestosterone.com/Prolactin_In_Men.aspx
https://www.peaktestosterone.com/Causes_High_Prolactin.aspx
https://www.peaktestosterone.com/Hypothyroidism_High_Prolactin.aspx

Re: high vitamin D, likely at 10K IU/day
https://www.peaktestosterone.com/Dangers_High_Vitamin-D.aspx

A "honeymoon" phase with TRT is quite common, and it's disappointing when it ends. One of the reasons for it is that initially you have an additive effect, with the injected testosterone combining with your own production. Over time your production shuts down. Although you can compensate for lower testosterone by increasing the dose, this can cause side effects, including excess estradiol, high hemoglobin/hematocrit, and it doesn't address other effects of an HPTA shutdown, including reduced progesterone. Adding hCG to a protocol can help in many cases. Progesterone supplementation is something to consider if you end up with low levels.

15
Testosterone, Hormones and General Men's Health / Re: New to the Site: Intro and Stats
« on: July 09, 2019, 05:23:02 am »
Welcome to the site. Here are some of my thoughts: Was anything done to address your initial elevated prolactin level? Did it improve? Did you have an MRI? In my opinion 50 mg is too much Clomid, especially as a starting dose. It should be slowly titrated upwards from 12.5 mg daily or EOD. I personally would be uncomfortable taking such large doses of pregnenolone. You're probably overdosing on vitamin D as well. Pushing serum levels above 50 ng/mL may have risks. Combining Clomid with testosterone cypionate is most likely going to be counterproductive. There are a few scattered reports of HPTA activity with this kind of treatment, but in most cases the exogenous testosterone overrides the stimulation provided by Clomid. Overall it seems like too much at once. I'd have preferred to see the prolactin addressed first, then maybe thyroid, and finally testosterone if it hadn't improved with the other treatments.

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