Are there any difficulties with an every other day dose, either in terms of injections/needles, or in getting a doc to approve one? The shorter intervals intuitively make sense as matching closer to the daily rhythm.
I'm one of those who uses Compounded T cream, currently at 10%. I had so much trouble with Androgel, the amount that I ended up applying, the cost, eventual skin thickening, and rotating sites, that I eventually gave up on Androgel. I will readily admit that it worked wonderfully at first. However after a period of time (many months) the dose had to be increased due to lack of absorption. Eventually, I could slather on what seemed like a cup of the stuff and still have T levels in the mid 200's a few hours after application. The time when levels should be highest.
I started to have rashes due to the Androgel and other prescription topical T products, and my dermatologist prescribed the T creme from a known good compounding pharmacy. Knowing it would solve the rash issues.
I had some trouble with injections too. The carrier oil would get into my lungs and cause coughing fits. Even with the Doc doing proper IM injections.
I'm currently using 10% compounded T creme. But not just any creme, one made by a pharmacy that does it right, and gets good T results. I have zero skin trouble with it, and absorption is good, resulting in a very consistent T level of 700 ng/dl. What I'm doing lately is an every other day application. (I tend to experiment a little) and it's been good. I simply apply more, every other day.
I have other health problems, autoimmune disease, and T levels are really the least of my concerns. I also have a failed thyroid, and very low cortisol, using too much T does not help the low Cortisol, so I keep my T levels 450-700 and doc adds in prednisone or hydrocortisone as necessary when AM cortisol drops below 7.
In my case T does 2 main things, I notice muscles respond to adequate T levels, and it drives my libido way, way up. Especially if I cycle on and off creme T. I'm not really sure why this is, but I do not get the same libido results from injections of any dose, type or frequency. But I absolutely get high libido with the compounded 10% creme, with either an every day or an every other day program. I also notice that excessively low T results in a form of worry. I'm a pilot and the best way to describe it is that with near nil T, I needlessly worry that the wing spar will break. With adequate levels I have confidence in the machine and can concentrate on my skills.
It really is too bad my wife is post menopausal and has zero interest, because I'm good to go in that department. It took me years to come to terms with the libido mismatch. But that's another subject entirely.