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Messages - Mindscape

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It could be perimenopause which happens years before hitting menopause. Doctors lack of concern is surprising, I wouldn't stop there, I would find a doctor that cares enough to look deeper.

I would push it a little higher, it's not like estrogen sides are an issue.

A 200mg every 2 weeks is terrible protocol and what we call a hormonal roller coaster, it pretty much explains why you quit TRT in the first place. It's amazing you did it for so long and hints that your doctor is rather incompetent.

My TRT protocol is a world apart from yours, I inject 21mg every 2 days. Most men do well on two 50mg injections every 3.5 days, some need more frequent injections.

Estrone and Estrogens Total has no diagnostic value at all. You need the Liquid Chromatography Mass Spectrometry or LC/MS/MS.

Sadly you experience is not uncommon and you will soon learn that the chances of finding a knowledgeable TRT expert under your insurance network will be extremely difficult if not impossible. You may have to go private.

Usually if you're having estrogen sides, you need to inject testosterone multiple times per week. Knowing your SHBG level is another piece of the puzzle, low SHBG men do well on frequent dosing. I'm lower SHBG (22) and feel good on an 21mg EOD and even better on daily dosing.

Defy Medical is another option, a telemedicine clinic that has knowledgeable TRT doctors.

You will get more replies if you break up that wall of text.

The question is where you undosed for your trial of thyroid treatment, pretty common these days, what were you labs?

Perhaps someday stem cell therapy or gene editing will allow a bald man to regrow all the hair he has lost.

Whatever you do stay away from DHT blocking medications, I mean you wouldn't block testosterone.

As I suspected SHBG while not very high is binding up a lot of your testosterone, this wouldn't be the first time I've seen someone with slightly above midrange SHBG and low Free T. There is a variability in the stickiness of SHBG from person to person, I've seen guys with SHBG in the 70's and Free T isn't nearly as low as yours.

SHBG is next to impossible to manipulate other than excess androgens which is where TRT come into play, TRT should lower SHBG quite well and increase Free T as well.

Testosterone production is probably very low and is being inflated by SHBG to look better than it really is and would expect LH to be low.


My experience endocrinologists are terrible at TRT and the problems with most endocrinologists is they were taught to only check TSH and maybe Free T4, they stay out of touch with the latest studies and literature and continue down the road of ignorance. Doctors are just following what they were taught, 10-20 years ago. As medicine evolves, doctors should evolve along with it and sadly that doesn't happen. 

If in the US give Defy Medical a call, they offer telemedicine.

Happy New Year Everyone.

Whenever I start a new TRT protocol I always get palpitations and heart rhythm disturbances at times which completely subsides after levels become stable after 6 weeks.

I heard of micro dosing clomid with TRT for fertility reasons, but what is your doctor trying to achieve?

Your thread title pretty much hints to your problem, you are hypothyroid and is the reason why you feel cold. Free T3 is the active thyroid hormone and soak into every cell in your body speeding it up and in turn increases your metabolic rates and therefore body temperature. Your Free T3 is below the ranges and needs to be midrange or preferably slightly higher to relieve symptoms.

You're low testosterone as well, low estrogen is associated with osteoporosis. Sometimes when testosterone is low, so to is estrogen since testosterone converts over to estrogen. TRT will increase your hemoglobin and RBC to optimal levels. 

You will need a TRT protocol designed around your already high SHBG, you may need a high total testosterone to have enough free testosterone. Probably large injections once or twice weekly, 140mg once weekly and 60mg twice weekly.

You're going to have to provide lab ranges for Free T, by labcorps ranges you are more than double the reference ranges and that doesn't makes sense. If it's the ranges I think it is, it's at the bottom of the ranges and if so you would expect to see hemoglobin on the lower end of the ranges.

You're at an age when testosterone is expected to be sub optimal, I believe your SHBG (produced in liver) may be binding a lot of your testosterone which is probably high normal, therefore decreasing Free T. You cannot restore testosterone levels at 52 years old, you levels have been on the decline ever since your early 30's and will continue to decline as you age, unless you have found a way to reverse the aging process.

You're symptoms are classic low testosterone, but also low thyroid hormone share some of the same symptoms as low testosterone. A lot of doctors fail to test for Free T3, it tells us what's going on at the cellular level, TSH only is useless as it isn't a thyroid hormone.

If you decide to start TRT avoid any doctor wanting to prescribe 200mg every 2 weeks which is very typical, this would be indicating your doctor doesn't specialize in TRT and is inept to be able to help you any further. A clinical study published back in 2005 indicates it doesn't work and actually causes more suffering than when compared to pre-TRT.

The statement, "this is all in your head" is a copout from someone who lacks initiative.

          So my doctor is now recommending I go on TRT. Still very nervous because im only 21, but Ive been dealing with this for 3 years and I dont think my hpta axis will recovery and I'm tired of feeling awful. My doctor is recomending androgel, but I was thinking testosterone DHT in injections would be best. What are your guys thoughts/ recommendations?

You need to find someone who specializes in TRT, typically endocrinologist do not specializes in TRT. Androgel is garbage only works for a very small percentage of men do to poor absorption through the skin.

Injectable testosterone is 100% guaranteed to work and is the least profitable version of TRT, but requires the most skill from your doctor.  Your TRT protocol should be designed around your SHBG levels, sadly the majority of doctors are not skilled enough to design a modern TRT protocol and set men on a path of prolonged suffering.

Be careful of any doctor recommending 200mg every two weeks as there are clinical studies showing it doesn't work. Odds are your doctor doesn't have a clue how to do TRT and is why the androgel was recommended.

Want to know how many members are on androgel, the answer in none, zero.

Muscular responses to testosterone replacement vary by administration route: a systematic review and meta-analysis.
Intramuscular TRT is more effective than transdermal formulations at increasing LBM and improving muscle strength in middle-aged and older men, particularly in the lower extremities.

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