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Topics - explorer

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[MODERATOR:  In fairness to explorer, he is not asserting that beef is heart healthy necessarily or even that beef lower cholesterol, but here are some things to think about.  And this is split from here: http://www.peaktestosterone.com/forum/index.php?topic=11236.0 ]

You can't just trim off the fat on most modern meats.  Wild game is typically 10-15% fat. Modern beef is about ~2-3X that and is just riddled with saturated fat

Beef fat contains stearic acid, a saturated fat that reduces cholesterol. It's one of the fats highest in stearic acid, so beef meat that is not very fatty will not have a big impact in increasing cholesterol

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Quote
Several companies have stopped using BPA in plastic production due to consumer outrage, but just because a plastic container says it is “BPA Free” doesn’t mean it’s free of potentially harmful chemicals. As a matter of fact, recent research out of Germany indicates there are more than 24,000 of such chemicals in any given bottle of water—with some of them causing serious hormone-disrupting effects.

Link

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High Fructose Corn Syrup is a source of heavy metals, according to these articles:

It contains Mercury:

Quote
The reason why some HFCS contains mercury and other HFCS doesn't has to do with how the sugary product is manufactured. IATP told the Minneapolis Star Tribune that four HFCS plants in Georgia, Tennessee, Ohio and West Virginia still used a technology known as "mercury-cell" that can contaminate the end product.

According to IATP, the process involves adding mercury-grade caustic soda, as well as other ingredients, to a proprietary mix that ultimately separates corn starch from corn kernels. This mercury-tainted caustic soda is manufactured in industrial chlorine plants that use an outdated and highly toxic chlor-alkali process that can leave mercury residue in the final product.


It contains Cobalt:

Quote
The enzyme, Xylose isomerase, is used to turn glucose to fructose in the high fructose corn syrup creation process; what you find out is that it requires cobalt ions to work.

Cobalt is a metal, heavier than iron, that is added to the isomerase to catalyze the process.

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Testosterone, Hormones and General Men's Health / IP6 For Chelation
« on: October 04, 2015, 12:35:02 am »
For those looking to chelate heavy metals, there are a bunch of claims about IP6. Some claim it chelates iron, mercury, lead, and cadmium.

I don't know how truthful the claims are, but if one is willing to self experiment, IP6 seems among the safest substances. Of course, one should take a look at the documented effects and side effects before testing it.

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NON- stick frying pans release chemicals linked to liver disease and cancer into the environment when exposed to heat, warns a study today.

Scientists who tested Teflon and other similar substances used to coat frying pans and ovens have called for a serious examination of the products.

They found that one of the cocktail of substances emitted was perfluoro acid, which accumulates in human tissue and which has been linked by other studies to liver disease and cancer.

Researchers also found that Teflon produces trifluoroacetic acid 'at an incredible rate'. High concentrations of this substance take decades to degrade in water and it can be poisonous to plants.

Read more: http://www.dailymail.co.uk/health/article-61407/The-deadly-toxins-non-stick-frying-pans.html#ixzz3moQwyibD

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Quote
Japanese researchers have successfully grown kidneys from stem cells that worked as they were supposed to after being transplanted into rats and pigs.

Read the rest.

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[MODERATOR SPLIT FROM HERE: http://www.peaktestosterone.com/forum/index.php?topic=7679.0]

Also of note, I got back my recent bloodwork I had done following up on my ferritin levels.

Ferritin alone can give the wrong information about iron stores. It's good to also have transferrin saturation, or transferrin receptor. Ferritin combined with one of these other two is more reliable.

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Testosterone, Hormones and General Men's Health / A DHEA Anecdote
« on: July 07, 2015, 03:58:59 am »
I found a DHEA anecdote on the Ray Peat Forum.

Quote from: Mittir
I have used DHEA regularly for about a year. Started with 2 mg and it gave me extra energy
and good muscle tone. But, in the beginning i had sore knuckle , it is different than joint pain.
I had that for first few weeks. I continued because of other benefits i was getting.
RP recommends taking DHEA with oil, either dissolved in oil or eating some oil with DHEA dose.
Oil makes DHEA processed in a different way by avoiding liver. Excess DHEA is toxic to liver.

It reminded me of RP's experience with DHEA, which increased his height at an older age and
straightening of wisdom tooth. It is possible DHEA did something with my bone fingers.

One of the side effect or benefit of dhea is increased libido. If i took DHEA at night
it disrupts my sleep. I took DHEA in the day time. Now i can take 5 mg of DHEA without
the kind of bad effects i had in past with 2 mg. It is definitely a very powerful hormone
even at lose dose of 2 mg. I am guessing my improved thyroid function and diet
has helped me with tolerating DHEA without any problem.

When i tried with larger dose of DHEA, i had breathing difficulty after waking up. This possibly mean
DHEA increased use of sugar and that lowered glycogen storage.

http://www.raypeatforum.com/forum/viewtopic.php?f=56&t=7168&p=88810#p88802

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Testosterone, Hormones and General Men's Health / Fatty Acids Test
« on: June 11, 2015, 01:01:30 am »
I noticed that blood testing is pretty big in this forum. How does my approach affect my blood levels? I noticed an exception though. A lot of people supplement fish oil, or flax seed, yet they don't do the fatty acid profile test to see where they are.

It's not like excess isn't a problem. Fatty liver disease is associated with having a lot of some types.

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Some guys might have someone they care about, so...

Quote
Breast cancer in women has been associated with elevated iron for the past thirty years. For example, in a study of
229 women with early breast cancer as compared with 250 healthy women of similar age, the mean serum ferritin of the
patients was 97 ng/mL; of the healthy persons, 57 ng/mL. Moreover, those patients with serum ferritin levels greater
than 200 ng/mL had a significantly greater recurrence rate than patients with lower serum ferritin values

Source

Maybe bloodletting is good not only for men...

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Testosterone, Hormones and General Men's Health / Fatigue and Iron
« on: May 23, 2015, 04:46:17 am »
When some of us investigate the cause of fatigue, it might be good to know that fatigue can be caused by both low and high iron. For males, though, excess iron is much more frequent, especially among those who don't donate blood.

More info here from the Iron Disorders Institute: Link

They also list hypogonadism as a symptom of excess iron.

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I think the question is not solved, but I want to point out that there exists data suggesting low levels are good. For example:

Quote
An interesting finding from our study is that inverse associations between the serum ferritin and antioxidant vitamin levels were observed even among subjects in the lower deciles of serum ferritin. This observation is, at first thought, counterintuitive because one might expect that relatively low ferritin levels may not contribute to iron-related oxidative stress. However, our observations correspond to those of Zheng et al, who showed clear improvement in flow-mediated brachial artery dilation in otherwise healthy frequent blood donors with a median ferritin of 17 ng/mL as compared with equally healthy but less frequent donors with a median ferritin of 57 ng/mL ( P = .001). Nakano et al

In other words, the study suggests that it's better to have ferritin of 17 than 57.

The study is "Comparison of the serum ferritin and percentage of transferrin saturation as exposure markers of iron-driven oxidative stress–related disease outcomes". You might be able to access the whole study if you're in an university.

Another piece of data is that a ferritin of 200 is considered within the range, but diabetic people with that level of ferritin who underwent blood extraction (which causes lower ferritin) reduced their symptoms of diabetes.

In one specific person, ferritin by itself is not always reliable because other factors such as hypothyroidism can cause both abnormal high and low numbers. Combining the ferritin reading with the transferrin saturation can help to determine the iron stores more reliably.

Hemoglobin is another main marker. If the main function of iron is formation of hemoglobin, adequate levels of hemoglobin suggest that one isn't deficient in iron (whether one has an ideal amount of stores is another question).

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High iron increases risk of diabetes.
If you already have diabetes and high iron, removing iron reduces symptoms, with benefits lasting even 12 months after phlebotomy.

Elevated serum ferritin levels predict new-onset type 2 diabetes
Blood Letting in High-Ferritin Type 2 Diabetes
Cross-Talk Between Iron Metabolism and Diabetes

===============================================

In animals, the cells of the pancreas that produce insulin regenerate when polyunsaturated fats are low, and sugar helps with that regeneration. So if I had diabetes, I would reduce iron, polyunsaturated fats, and gradually add sugar from fruits or honey as it's comfortable. Coconut oil also protected from diabetes in some animals experiments. All this is completely natural by the way.

It's well established that iron and polyunsaturated fats enhance each other's effects, so something that is damaged by iron is likely to be damaged by polyunsaturated fats as well, and vice versa.

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