From Dr. Kendrick's blog: https://drmalcolmkendrick.org/
Kendrick tends towards a theory of clots and plaque being related. And in the end he seems to indicate that clotting factors increase CVD and plaque (coronary vascular disease)
Non-steroidal anti-inflammatories e.g. brufen, naproxen
Biomechanical stress (within arteries)
Systemic Lupus Erythematosus
Antiphospholipid syndrome (Hughes syndrome)
Vitamin C deficiency
Raised fibrinogen levels (key clotting factor)
Bacterial infections inc. gingivitis
Increased plasminogen activator inhibitor – (1 PAI-1) levels (critical factor in blood clot repair/breakdown)
I could have kept going, but that is enough for now. What do all of these things have in common. They increase the risk of atherosclerotic plaque formation, death from CVD. Most importantly, of course, they cause endothelial damage and/or increased blood coagulability. And I could not, and cannot, think of anything else that links them all together.
Then I started to think about factors that reduce the risk of CVD.
Exercise (overall, not whilst doing it)
Moderate alcohol consumption
Clopidogrel (expensive aspirin)
ACE- inhibitors (a blood pressure lowering agent)
Von Willibrand disease (lack of a specific clotting factor in platelets)
B vitamins (enough to reduce homocysteine)
Adequate Vit C (no idea what the correct intake should be)
Potassium (higher consumption reduces platelets sticking together)
Nitric Oxide (through sunlight – and other nutrients e.g. l-arginine)
Magnesium (and other micronutrients)
What do all of these things have in common. Well, once again, they either protect the endothelium, or they reduce blood clotting. And they all reduce the risk of CVD.
To my mind there was, and is, an almost perfect correlation. But, as I said earlier. Looking for supportive data is all very well. Can you find the black swan? Or black swans. Are there facts that completely contradict the ‘it’s all to do with blood clots’ hypothesis of CVD?