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Topics - ht

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My last 2 blood draws have returned a T value of 994 and 1016.  I have the blood draw on the last day of my 4 day cycle.  My values seems a little high, and I'm a bit concerned about hair loss and high hematocrit, both of which seem to be heading in the wrong direction lately.  I'd like to bump things down a bit, so that I end up no higher than the 700's on the last day of the cycle.  I'm currently taking 56mg (.28cc) per injection.  If I want to lower my values by 15 to 20%, is it as simple as just cutting the dose by 15 to 20%, or is it more complicated than that?  Any other suggestions?

2
There is plenty of good research on the benefits of glycine for anti-aging (1), sleep (2), restoring youthful glutithione levels (3), etc.  I've been taking 3g every day before bed, and I do sleep noticeably better when I take it.

However, after taking it like this for about 2 or 3 weeks straight, I start to get extreme daytime sleepiness.  Even after a perfect 8 hours of sleep, I'm groggy all day and can't wait to crawl in bed at night.  I'm not 100% sure it's the glycine, but I'm 90% sure.  The only other real possibilities are some transient sickness, or worse than usual allergies.  I've just finished my 3rd try of supplementing with glycine, and each time I've have to quit for a while just to be able to function like a normal person again.  I think the health benefits are pretty clear cut, so I'd like to continue with it, but I can't handle the fatigue.  The thing is, I can't find any study or even an anecdotal report that talks about fatigue associated with glycine.  The glycine sleep study even reported an improvement in daytime sleepiness due to the better sleep, so I'm baffled.

Does anyone else take glycine regularly, and have you experienced fatigue?

1. http://www.fasebj.org/content/25/1_Supplement/528.2
2. http://holisticprimarycare.net/topics/topics-o-z/vitamins-a-supplements/1249-a-new-approach-to-promoting-healthy-sleep-
3. http://www.ncbi.nlm.nih.gov/pubmed/21795440

3
I'm on Test Cyp.  I tried going subQ back in December, going from IM 200mg E14D, playing around with a few different dosages and schedules, and currently at SQ 54mg E4D.  I had just started feeling pretty good from the TRT right before I went SQ, so naturally I had to throw a wrench in things and switch it up.  I felt amazing -- by far the best ever -- for about 3 weeks after going SQ, and then it all faded away.  Now I literally don't even feel like I'm on TRT at all, in any way.  I've come to the conclusion that maybe that successful period was the tail end of my IM doses.  In the midst of feeling great (Mid-December) my T was around 650.  By mid-January, on a smaller dose of SQ it was around 420.  I've since raised the dose back to the same amount (per day) as when I was on IM, but without any noticeable change in how I feel.

I'm going to give this full SQ dosage 40 days to reach steady state, but my hopes are low since I'm at about 20 days and feel *nothing*.

Has anyone else tried SubQ and found it ineffective, and went back to IM with success?

4
I've been doing E4D subq injections for the past month.  I use .18cc in a 1/2" 30g needle, injecting into the fatty area about 1.5 to 2 inches to the left or right of my belly button.  I alternate the left and right sides.  I don't go straight in, but fairly close (maybe 60 deg angle?)

The majority of times, I have no pain and no redness after the injection.  A couple times though, I've had a small lump that is a bit tender.  My last one is the worst so far.  I'm already due for another injection today, and the lump from the last injection is still as large and tender as I've ever had.  The lump is about the size of a nickel (but thicker and rounded), and is slightly pink, and as I mentioned, quite tender to the touch.

Is this normal?  Am I doing anything wrong?  I'm still pretty new at this.

I've had a lot of success with subq, symptom-wise, but my doctor tried to talk me out of it initially.  "Fatty necrosis" was what he mentioned.  I think his concern was probably on the assumption that I would do his recommended E14D 1cc dosage subq, which I obviously don't.  Unfortunately, I can't find anything about fatty necrosis and T injections online.

5
[MODERATOR SPLIT FROM HERE: http://www.peaktestosterone.com/forum/index.php?topic=8670.0.]

Do you have any standard hypothyroid symptoms with that low T3?

Nothing that unmistakably points to hypothyroidism.

That would be much appreciated!  This is definitely on my to do list.  I just found out that high dose niacin can negatively impact methylation:

http://mthfr.net/overmethylation-and-undermethylation-case-study/2012/06/27/

Here's what I have on links between Niacin and homocysteine, & homocysteine and ED:

http://www.ncbi.nlm.nih.gov/pubmed/17142125
There was a significant negative correlation between mean Hcys level and mean International Index of Erectile Function domain score (P < .001). The penile color Doppler ultrasound findings showed that there was a negative significant correlation between mean Hcys level and the 1st, 5th, and 10th minute's peak-systolic velocity. Logistic regression analysis revealed that age and Hcys levels were the main determinants in ED. Hyperhomocysteinemia, known to be an important risk factor in endothelial dysfunction, seems to be an important determinant in ED. These data suggest that slightly elevated Hcys levels are significantly related with arterial and probably endothelial dysfunction in patients with ED.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1994037/
A first analysis in humans whether niacin may also influence homocysteine was made in the Arterial Disease Multiple Intervention Trial (ADMIT). Homocysteine was measured in subgroups treated either with niacin (n = 24) or placebo (n = 22). After 18 and 48 weeks of treatment with niacin, average homocysteine levels were 21.1 and 19.9 Ámol/L in the niacin group and 11.5 and 11.6 Ámol/L in the placebo group, respectively.

http://www.ncbi.nlm.nih.gov/pubmed/19694922
Hyperhomocysteinemia in patients homozygous for the C677T mutation may interfere with erection mechanisms and thus be responsible for ED. In case of hyperhomocysteinemia associated with low levels of folates, the administration of PDE5 inhibitors may fail if not preceded by the correction of the alterated levels of Hcy and folates.

6
TL;DR version:

Help!  Five weeks ago, I started TRT (200mg Test Cyp IM every 2 weeks) for Low T and ED issues.  I have felt *no* positive side effects so far, and truthfully, not much of any effects of any kind.  This doesn't seem normal at all.  Should I get off TRT and look elsewhere, or am I being impatient?  If TRT is not the answer, I want to find out as soon as possible.

Really long version:

I'm in my early 40's.  About 4.5 years ago (in my late 30's), I started having more difficulty getting erections and within a couple months practically lost the ability to get an erection at all.  Before that my sex life had been really amazing, so it was quite a spectacular nosedive.  I took some tests and found my T to be very low.  Fast forward to the present, and things are somewhat better but nowhere near normal.  Thanks to my incredible (and incredibly patient) wife, my sex life is not horrible, but there is always the issue of whether my equipment is going to work at all, and if so, to what extent.  At no time in that 4.5 years have I had 100% "normal" sex that just worked like it's supposed to.  That is incredibly stressful to bear for years on end, and I swear it will send me to an early grave if things don't improve at some point.  At this point, any (even trivial) sexual thoughts literally make me feel ill with anxiety.

My T has fluctuated between 211 and 489 in that time span.  My free T has always been low, right around 6.  LH is 1.4 mIU/mL.  Estadiol between 8 and 11.  Prolactin is 6.2ng/mL.  So pretty much panhypopituitary.  My cholesterol is high (240-ish), but my HDL is also high (75-80) so the ratio is actually pretty decent.  I'm not a gym rat, but I'm above-average physically fit for my age.  I work out and run about 2-3 times a week.  Diet can always be improved, but mine is IMHO very good.  I eat practically no sugary or processed foods.  I do get morning wood.

I've been avoiding TRT for years, and had checked apnea, hemochromotosis issues, and many other dead ends.  I tried to raise my T naturally with weight loss, vigorous lifting, and good eating.

When nothing worked, I finally bit the bullet and resigned myself to TRT.  I wasn't happy about the lifelong prospect of it, but I figured it would at least solve my ED problems, right?  The endo said I would feel something (or not) within 72 hours.  Most studies I've looked at said the first effects of TRT are seen at 3 weeks.  I'm at 5 weeks in, and I have felt NO positive effects at all.  None.  I do have some mild negative effects: shrunken testicles, painful testicles, more body hair, gained about 5 pounds (all belly fat AFAICT), and the desire to break something if I get frustrated (I'm usually a very laid back guy).  If I had to rate my ED, I'd actually say it's a hair worse since I started TRT.  With a 2 week cycle, I expected to have high high's and low low's, but I've pretty much just felt nothing.

So... am I just being impatient?  Shouldn't I feel something in 5 weeks?  Should I stay the course, or am I possibly not even on the right road here?

Assuming I should stay on TRT and just need to adjust dose/timing or contain E2, when should I get tests to check T and E2?  I've read studies that do the testing the morning before the injection, and again 48-72 hours later, to establish peak and trough.  Is that a good plan?

7
5 weeks ago, my endo started me on 200mg T Cypionate IM every 2 weeks.  I'd like to switch to equivalent weekly subq injections, but when should I switch over?  When I'm due for my next injection on the 2 week schedule?  Or sooner?

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