« on: December 02, 2015, 08:07:57 pm »
Help! Five weeks ago, I started TRT (200mg Test Cyp IM every 2 weeks) for Low T and ED issues. I have felt *no* positive side effects so far, and truthfully, not much of any effects of any kind. This doesn't seem normal at all. Should I get off TRT and look elsewhere, or am I being impatient? If TRT is not the answer, I want to find out as soon as possible.
Really long version:
I'm in my early 40's. About 4.5 years ago (in my late 30's), I started having more difficulty getting erections and within a couple months practically lost the ability to get an erection at all. Before that my sex life had been really amazing, so it was quite a spectacular nosedive. I took some tests and found my T to be very low. Fast forward to the present, and things are somewhat better but nowhere near normal. Thanks to my incredible (and incredibly patient) wife, my sex life is not horrible, but there is always the issue of whether my equipment is going to work at all, and if so, to what extent. At no time in that 4.5 years have I had 100% "normal" sex that just worked like it's supposed to. That is incredibly stressful to bear for years on end, and I swear it will send me to an early grave if things don't improve at some point. At this point, any (even trivial) sexual thoughts literally make me feel ill with anxiety.
My T has fluctuated between 211 and 489 in that time span. My free T has always been low, right around 6. LH is 1.4 mIU/mL. Estadiol between 8 and 11. Prolactin is 6.2ng/mL. So pretty much panhypopituitary. My cholesterol is high (240-ish), but my HDL is also high (75-80) so the ratio is actually pretty decent. I'm not a gym rat, but I'm above-average physically fit for my age. I work out and run about 2-3 times a week. Diet can always be improved, but mine is IMHO very good. I eat practically no sugary or processed foods. I do get morning wood.
I've been avoiding TRT for years, and had checked apnea, hemochromotosis issues, and many other dead ends. I tried to raise my T naturally with weight loss, vigorous lifting, and good eating.
When nothing worked, I finally bit the bullet and resigned myself to TRT. I wasn't happy about the lifelong prospect of it, but I figured it would at least solve my ED problems, right? The endo said I would feel something (or not) within 72 hours. Most studies I've looked at said the first effects of TRT are seen at 3 weeks. I'm at 5 weeks in, and I have felt NO positive effects at all. None. I do have some mild negative effects: shrunken testicles, painful testicles, more body hair, gained about 5 pounds (all belly fat AFAICT), and the desire to break something if I get frustrated (I'm usually a very laid back guy). If I had to rate my ED, I'd actually say it's a hair worse since I started TRT. With a 2 week cycle, I expected to have high high's and low low's, but I've pretty much just felt nothing.
So... am I just being impatient? Shouldn't I feel something in 5 weeks? Should I stay the course, or am I possibly not even on the right road here?
Assuming I should stay on TRT and just need to adjust dose/timing or contain E2, when should I get tests to check T and E2? I've read studies that do the testing the morning before the injection, and again 48-72 hours later, to establish peak and trough. Is that a good plan?