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Topics - doin it

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1
Testosterone, Hormones and General Men's Health / Where ?
« on: December 29, 2020, 01:36:47 am »
I have not been very active for awhile until lately, but when I was active a while back, there were regular comments from guys like boxcar and joe sixpack (I miss their comments) and others.  Not to mention the moderators (Moderators: Cronos, Kierkegaard, Hydranted, euphorixx1) who NEVER comment anymore, are they still alive and read this forum ???

THANK YOU CAT for doing the heavy lifting !!!

(Glad ghce, flyong fool and others have hung in)

2

Cat,

I am going to change from T Cyp 2x/week to T prop. every day.

Please check me on the following.

 I am doing 44 mg TC per week which is 70 % T
(100 mg = 70 mg actual T)

0.11 ml x 2 per week = 0.22 ml = 44 mg per week
44 x .7 = 30.8 mg actual T per week
At 200 mg/ ml

This would be 4.4 mg actual T per day if I were injecting daily
(30.8 / 7 = 4.4)

---

So, to get the equiv. with TP,

TP is actually 80 % T

Empower is 100 mg /mL

10 mg = 0.1 mL or 0.1 cc
1 mg = 0.01 mL or 0.01 cc
So
11 mg = 0.11 mL or 0.11 cc
So
31 mg = 0.31 mL or 0.31 cc
And
38.5 mg = 0.385 mL or 0.385 cc

But 31 mg is actually 24.8 mg T
And
38.5 mg = 30.8 actual T
So
38.5 mg = 0.385 mL or 0.385 cc

Proof
100 mg/mL x .8 = 80 mg actual T
= 80 actual mg T per mL

30.8 mg/ 80 mg = 0.385 mL or 0.385 cc per week

0.385 / 7 days a week = 0.055 mL (cc) per day

---

So
In a 3/10 syringe where
3/10cc (0.3 ml) or 30 units

0.01 mL equals 1/100 cc (0.01 cc) , 1 unit

0.055 mL (cc) = 0.055 cc or 5.5 units per day

1) Is all this correct ?

2) After stopping T Cyp, how many days should I wait to start TP ? (40 days (5 half lives ?))

3) After starting TP, how many days should I wait for the first T, etc. tests ?

4) How many hours should I wait to test after injecting ?

Thanks in advance.

3

A couple weeks ago, I saw that I would need alcohol prep pads in a few weeks so went looking.  As you can guess, there is no such thing at stores ( and alcohol same story).
My goto is BD which has been non-exsistent for months.
So went to Walgreens looking and happened to pass the manager and commented to her that people are hoarding alcohol and prep pads and leave none for me and I NEED them.
She said you can just use alcohol and a gauze pad and I said yes I know, where can you buy alcohol ?
She said "come with me, I think I can help you".
She went into a side door to, I guess, a store room, and came out with, can you believe it, a bottle of 91 % rubbing alcohol.

She said she keeps a few bottles for people like me.
I profusely thanked her, another hero, and carried my treasure home.
So, if you guys cannot find alcohol or prep pads, check with a Walgreens manager.  Maybe it is is an internal directive ?

Good luck !

4

Interesting;  vote for consuming raw milk?

 https://www.realmilk.com/health/tale-of-two-calves/

Most significantly, the testicles of the pasteurized milk calf appeared to be about 30 percent smaller than the testicles of the raw milk calf.

5

Just a note regarding LH and FSH shutdown with TRT.

I am Primary and I tuned my T Cyp dose (SubQ abdomen, 2 x/ wk) into the "normal" range while maintaining T and E2 at about 650 and 25 respectively.
Note: I am high SHBG.

It CAN be done but takes a patient and understanding doctor as not shutting down LH and FSH was my goal.  Also several lab panels.

6
Testosterone, Hormones and General Men's Health / T Cream Concentration
« on: November 22, 2019, 04:58:52 pm »

So, in the past, I have taken topical T (Alc and creams) and it did not work well for me as DHT was too high (850 +) and T was not improved much, also E2 was lower (7).
So went to T Cyp SubQ 2x per week (abdomen) for a year and it worked very good ( all parameters were good).

But, I want to go to a diurnal T routine ( instead of steady-state) but do not want to do daily injects (would not work anyway because of T Cyp 5 to 7 day half life) , so am going back to a cream, 1 mL daily ( 100 mg/ mL) for a dose of 100 mg a day.

First part of my question is, should I do a concentration of 100 mg/ mL and do 1 mL, or, 10 mg/mL (like Androgel) and apply 10 mL to obtain an effective dose?
(Ignoring the messiness and volume)

Before you answer, note that one of the major complaints about Androgel (1 %) is that guys do not llke having to apply so much liquid ( 5 to 10 mL for a 50 to 100 mg dose respectively).

You would think that after so many complaints about Androgel having to apply so much liquid, that they would  increase the concentration to lower the amount of liquid required.

They did increase to 1.62 % but even with  that small concentration increase, a large amount of liquid is still required.

Second part of my question is, do you think that they cannot make Androgel "work"* unless it has a small concentration ( no greater than 1.62) with a large amount of liquid?
(Spread over a large skin surface)

* "Work" means T increases to "normal" with all other parameters staying within "normal" ranges.

Thanks
Doin it

7
A compounding pharmacist asked if I wanted any particular T (compounded) skin delivery vehicle as there are now several new ones that increase the amount of T delivered through the skin.  I am now researching the various delivery vehicles, does anyone know what their compounded gel/cream delivery vehicle is and does anyone have any recommendations?
Thanks

8
Testosterone, Hormones and General Men's Health / Inject T USP ?
« on: April 17, 2018, 03:37:35 am »
Does anyone inject T USP IM as TRT ?
 (Recognizing that it cannot be injected SQ as it would aroamatize immediately)
TRT, not roid abusers (no offense intended).


9
Testosterone, Hormones and General Men's Health / Milk ?
« on: April 06, 2018, 09:33:22 pm »
Pasteurized Milk gets a bad rap for a lot of reasons.  Raw, unpasteurized milk is said to be much better but still gets bad-mouthed for fat, etc. content.
Many guys on this forum either lift or are very health concious or both, I'm wondering how many of you guys drink milk and how much every day and is it raw and unpasteurized?

I read once that humans are the only creatures on Earth that drinks the milk of a different species.

10

I have not seen this movie YET, it was recommended highly, but have ordered the DVD.  The following review further inspired me to buy it, along with 14,816 others (that rated it 88 % "1" and "2".  I am always looking for inspirational movies.

" This was my cure for cancer. No joke. After chemo, after radiation, there comes the anxiety of how to live "cancer free." When will it come back? Will my life every be the same? Will I ever be normal? If the Martian can live with all his uncertainty about survival, I sure can too! Didn't expect this movie to be life-changing or a cancer healing message, but maybe if you're struggling with any kind of anxiety, this movie and how its main character faces his problems head on, without worrying about when the next one will come, can be inspirational to you too"

The Martian

 https://www.amazon.com/Martian-Blu-ray-Matt-Damon/dp/B017S3OP34/ref=sr_1_3?s=movies-tv&ie=UTF8&qid=1521860436&sr=1-3&keywords=The+martian&dpID=51pSxH8tGRL&preST=_SY300_QL70_&dpSrc=srch


11



My LDLs are, at this time, unfortunately, of the predominately small, angry variety instead of the large, fluffy, friendly type.  In looking for ways to reverse this situation, I ran accross the connection of Fatty Acids to LDLs.

Also, if fatty acid levels are abnormal, it can cause a whole range of issues, so I  recently got aa ARUP Fatty Acids blood test that shows the status of 20 fatty acids.  The results are listed for each one and they characterize your status in several ways ( look at the example report) and you also get a really groovy color graph (kinda like a polar graph), link follows:

(after going to link, click on the "Example Report " for "Fatty Acids Profile, Essential Serum or Plasma", test number 2013518 in the table), it is a download.

 https://www.aruplab.com/testing/enhanced-reports

These acids affect the body in SO many ways, I cannot offer links.  Just Google (and pubmed) your particular health issue with "Fatty acids" to see if it is applicable to you.

12
Testosterone, Hormones and General Men's Health / Tibolone: Anyone Use It ?
« on: February 09, 2018, 05:47:11 pm »

Apparently Tibolone increases E2 and/or mimics it.

https://en.m.wikipedia.org/wiki/Tibolone

Anyone ever used it ?

13

But then, I didn't feel real good ALL the time when in my late teens/ early 20s (with exceptional lebido/performance and stamina btw) when, I'm assuming, my T levels were ok (don't know, never felt the need to go get tested).

I recall one day when I was 21, my workout partner came by to pick me up after work at my apt to go work out and I told him I didn't feel like it and said I wasn't going that day.  He said that is the time you gotta push yourself and go which will make it easier and easier to go as time goes on.  And he was right of course cause (as you all know) once I got there, I was glad I went.
 
Course he was a couple years older and been working out a lot longer and so was wiser about such things.

(It did happen one time in the year we worked out together that I had to tell him the same thing and he laughed and said "let's go")

I have to remind myself of these times so that I don't expect too much all the time.

14

July 2016
Journal Of Endocrinology

 http://m.joe.endocrinology-journals.org/content/230/1/R13.long?view=long&pmid=27113851#sec-1

1)  There are SHBG "variants"

2)  "The mathematical models used to calculate free plasma androgen or estrogen levels currently rely on SHBG measurements obtained using immunoassays (Vermeulen et al.1999), and they are based on the assumptions that all SHBG molecules react similarly immunologically and have identical steroid-binding properties. These assumptions are fallible, however, because some SHBG variants are not recognized in immunoassays, while others have abnormal affinities for sex steroids (Wu & Hammond 2014), including the SHBG P156L variant with a reduced affinity for testosterone that is present in ~1% of Caucasians, and increases the free fraction of testosterone in the blood of male carriers (Ohlsson et al. 2011)".

This may be further confounded as different labs use different methodologies for SHBG measurement.

Also suggests that there could be different affinities for different ethnic groups.

Additionally, immunoassays are, in some cases, known to be inaccurate.

3)  "These findings highlight the pressing need for sensitive mass spectrometric methods to measure both total and free sex steroid levels in the blood."

4)  "...They also illustrate the limitations of current methods for measuring their plasma concentrations, which are used in algorithms to calculate free steroid levels, and highlight the need for more direct methods to measure plasma free steroid concentrations..."

So, is Direct Free T Measurement Superior to a calculated value ?

Among the several interesting topics in this paper:
"Despite the large number of SHBG measurements performed for diagnostic purposes, it is remarkable that there have been only two reports of complete SHBG deficiencies in humans .. "
(went on to describe the symptons)

15

https://www.ncbi.nlm.nih.gov/m/pubmed/16143106/

Full text:
 http://www.cell.com/cell/fulltext/S0092-8674(05)00651-3?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867405006513%3Fshowall%3Dtrue

Androgens and estrogens are transported bound to the sex hormone binding globulin (SHBG). SHBG is believed to keep sex steroids inactive and to control the amount of free hormones that enter cells by passive diffusion. Contrary to the free hormone hypothesis, we demonstrate that megalin, an endocytic receptor in reproductive tissues, acts as a pathway for cellular uptake of biologically active androgens and estrogens bound to SHBG. In line with this function, lack of receptor 

In line with this function, lack of receptor expression in megalin knockout mice results in impaired descent of the testes into the scrotum in males and blockade of vagina opening in females. Both processes are critically dependent on sex-steroid signaling, and similar defects are seen in animals treated with androgen- or estrogen-receptor antagonists.

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