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Topics - Steve78

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1
If I was on nandrolone with my trt (100mg a week) along with 100 mg test weekly and 300 iu hcg every 3 days and .25 arimidex twice a week, and my wife may be pregnant, is there any level of concern about me exposing her via sex etc to any chemicals that may harm the fetus?
I cannot find any info on this anywhere ...

2
Ie, anyone on trt get their LH up to normal range with Kisspeptin and if so what dosing did you use?

3
My dose of trt is 90 mg a week, my TT is 671 (250-1100) but my free T is 200 (35-155)
Should I stay with same trt dose?  My doc friend who does hrt says I should get my TT up to 800-1000

4
Anyone lower their trt dose and add enclomiphene and have their LH increase to normal levels or see it increase?
Just curious

5
Testosterone, Hormones and General Men's Health / Mk677 vs hgh
« on: May 23, 2020, 12:31:14 am »
Would 25 mg mk677 increase igf like 2 iu hgh?
I canít find this info... 

Hereís one study on mk677:

Researchers from the University of Virginia in Charlottesville, Vanderbilt University in Nashville, Tenn., the University of Kentucky in Lexington and Merck Research Laboratories conducted a two-year, double blind, randomized, placebo-controlled trial. They enrolled 65 healthy men and women aged 60 to 81 years. Forty-three participants were randomly assigned to receive 25 mg MK-677 daily and 22 were assigned to placebo.

At one year, GH and insulin-like growth factor I levels of participants receiving MK-677 increased to levels of that of healthy young adults. GH levels increased 1.8-fold from baseline, and IGF-I levels increased 1.5-fold. Mean fat-free mass increased by 1.1 kg in the MK-677 group, but decreased by Ė0.5 kg in the placebo group (P<.001). Body cell mass also increased in the MK-677 group by 0.8 kg compared with a Ė1 kg decrease in the placebo group (P=.021).

The researchers observed no significant differences in abdominal visceral fat or total fat mass, but the MK-677 group had a greater increase in limb fat ó 1.1 kg vs. 0.24 kg in the placebo group (P=.001). Body weight increased by 2.7 kg in the MK-677 group and by 0.8 kg in the placebo group (P=.003).

According to the study, the most frequent adverse effects of MK-677 were increased appetite; transient, mild lower-extremity edema; and muscle pain. ďChanges in bone mineral density consistent with increased bone remodeling occurred in MK-677 recipients. Increased fat-free mass did not result in changes in strength or function,Ē the researchers wrote. Ė by Tina DiMarcantonio

Ann Intern Med. 2008;149:601-611.

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In this paper, Nass et al reported their results of a two-year randomized crossover trial in a group of 65 healthy adults aged 60 and 81 years treated with the GH secretagogue MK-677 or placebo (2:1 ratio) for one year, followed by three arms for year two, ie, continuation of MK-677, crossing over to placebo from MK-677 or crossing over to MK-677 from placebo. These studies were detailed and thorough, and the researchers ought to be commended for the tremendous amount of work the studies represent. The striking result is the very substantial increase in GH pulsatility sustained at 12 months as well as the sizable increase in IGF-I concentrations observed in the MK-677 group. Their key outcome of changes in fat-free mass was positive for the participants randomly assigned to MK-677 who gained 1.5 kg (along with total body water) whereas those receiving placebo lost 0.5 kg (P<.001). However, there was no difference in the abdominal visceral fat mass between the groups, and appetite and total body weight increased more in the MK-677 group. There was no improvement on any functional measures of muscle strength in the groups studied. Other factors were not favorable, including an increase in BMD of the femoral neck in the placebo group and a decrease in the MK-677 group. LDL decreased for those who received MK-677 vs. placebo; however, measures of insulin sensitivity declined with MK-677. Assessment of quality of life did not change in either group. The tolerance of the drug was adequate.

Overall, I think these data are important as they show the establishment of 'younger' GH pulsatility and IGF-I generation in the elderly with the use of MK-677. However, the issue remains: Is a 'younger' GH profile healthy in the elderly? The increase in fat-free mass was mostly secondary to total body water and was not accompanied by measurable increases in muscle strength. Intra-abdominal adiposity did not decrease, and total body weight and insulin resistance increased on the medication. It would be intriguing to explore whether the increase in fat-free mass observed could translate into increased muscle strength if accompanied by concomitant increase in exercise activity. It would also be important to assess the changes in the participants that ended up receiving the drug for two years (data not shown). Based on the data presented thus far, the benefits of MK-677 do not outweigh the risks, and MK-677 does not seem to be a 'fountain of youth' in elderly patients.

Ė Nelly Mauras, MD

6
Testosterone, Hormones and General Men's Health / HMG?
« on: May 05, 2020, 03:50:36 pm »
Iíve read conflicting info on this, one site says hmg is a mixture of LH and FSH whereas another says it stimulates the release of them.   Cat?

Any role in trying it with trt or using it to try a restart?

7
Testosterone, Hormones and General Men's Health / Testosterone and UC
« on: April 04, 2020, 03:57:31 pm »
Read up a lot on ulcerative colitis and seems like there is a hormone link.  People who get on androgen deprivation therapy have an increased risk etc.

My wife has ulcerative colitis and has tried almost everything (lialda, azathioprine, humira, etc)

I spoke with her about the testosterone and I think sheís willing to try (she is very conservative and would have never wanted testosterone but she wants her life back).

Not much literature on this but worth a shot.  I have no idea how much to give, she wants 2 mg (smallest amount I can draw up in insulin syringe).   Anyone know more on this or what women dosing should be?
I canít get the cream, I have only the oil

Also. Test does lower cortisol correct?   

8
Testosterone, Hormones and General Men's Health / Hcg monotherapy protocol?
« on: February 23, 2020, 03:26:30 pm »
Seems like a wide range of doses for hcg.
I found a study on it and they used 1500 iu hcg 3 times a week with great results and long term follow up:


Back to 2014 Annual Meeting Abstracts

Human Chorionic Gonadotropin is Effective as Monotherapy for Men With Symptomatic Testosterone Deficiency (Hypogonadism)
Ravi Kacker, MD, Mark Abair, BS, Kenneth C. Byl, BS, William Conners, III, MD, Abraham Morgentaler, MD.
Men's Health Boston, Brookline, MA, USA.
BACKGROUND: Administration of human chornionic gonadotropin (hCG) is an FDA approved treatment for hypogonadotrophic hypogonadism. hCG stimulates the testicles to produce testosterone and unlike testosterone therapy, preserves fertility and testicular volume. We present our experience with hCG monotherapy for symptomatic testosterone deficiency at an outpatient andrology clinic.
METHODS: An institutional review board approved retrospective chart review identified 42 men who started on hCG monotherapy for symptomatic testosterone deficiency at Menís Health Boston (Brookline, MA). All men had a total T <350ng/dL or free T <1.5ng/dl, received instruction with a nurse educator on drug preparation and self-injection, and were seen in follow-up. Starting dose was 1500IU three times a week and adjusted based on symptomatic response and lab results.
RESULTS: Mean age was 39.6y (range 20 - 62 years) and mean follow-up was 12.9 months (range 1.5-49 months). The primary reason for pursuing hCG therapy was to maintain fertility for 34(80.9%) men and to preserve testicular volume and function for 8(19.1%) men. 24 men (50.7%) were on clomiphene citrate or T prior to switching to hCG therapy. hCG therapy resulted in a satisfactory biochemical and symptomatic response in 40 men (95.2%). Mean total T levels increased by 709 Ī 303.9 ng/dL (p <0.001) and mean free T levels increased by 2.02 Ī 0.87 ng/dL (p<0.0001). Successful treatment was noted over a broad range of baseline LH levels, ranging from 0.9-14.3 IU/ml, mean 3.9 IU/ml. 27 men (64.3%) continued on 1500IU three times weekly for the duration of therapy, 8 men (19%) had their dose increased and 7 men (16.7%) had their dose decreased. Two men (4.8%) discontinued hCG due to lack of efficacy and 7 men (16.7%) discontinued hCG in favor of T when infertility no longer was an issue. 6 (14.2%) men developed nipple sensitivity or breast swelling, which resolved in 5 men after reducing the dose or with the addition of an aromatase inhibitor or SERM. 2 men (4.8%) developed hematocrit over 54, one of whom continued hCG at a lower dose.
CONCLUSIONS: hCG is an effective and durable treatment modality for men with testosterone deficiency, even in men with LH levels in the high-normal range. Advantages over standard testosterone therapy include preservation of fertility and testicular volume. The primary limitation of this treatment is inconvenience, as it requires subcutaneous injections three times weekly.

9
Testosterone, Hormones and General Men's Health / Increasing life span
« on: January 19, 2020, 03:28:59 pm »
Iím 41, natural TT was highest at age 29 (388), in my 30s it was 155.

Iím on trt now and loving it.  My question is how do I try to increase longevity?

I read on here that people live longer with E2 between 20-30, live longer if igf-1 is lower normal etc...

But what about TT?  Should I shoot for 600? Or go higher end 800-1000? Also, what igf-1 levels etc?   

Anything else I can do?  Intermittent fasting, metformin etc?   I do weights 4 times a week and cardio Iím starting 3 x a week.  Also trying to increase fiber with Metamucil etc.

Hopefully others have points

10
Testosterone, Hormones and General Men's Health / Questions about hgh
« on: January 12, 2020, 04:32:56 pm »
41 on trt, got it dialed in, love it!  Still want to add some lean gains and fat loss and feel even better.  I donít want to blast with oxandrolone or nandrolone as health is main concern.  Read a lot about hgh but one concern is increased cancer risk etc.  read kids on it have increased lymphoma/leukemia risk...

Anyone with info, is the cancer risk real and should it be avoided? 

11
Just curious whatís defyís hcg monotherapy protocol?

Iím guessing 500 iu EOD with say .1 mg arimidex EOD with it?  Does that seem reasonable?   Just a discussion

13
Testosterone, Hormones and General Men's Health / My lupron experience
« on: November 28, 2019, 11:07:15 pm »
Long story but Iím on trt and always wished coming off for various reasons.

Iíve committed to trt essentially but recently came across a bottle of lupron from a pharmacy (similar to triptorelin a gonadal tropin releasing hormone, ie stimulates increase LH and fsh)

Itís used for prostate cancer cause long term chronic LH overstimulation causes LH suppression. Studies show that after the first week or two LH raises and testosterone rises accordingly

So hereís my story my last trt dose was 40 mg test and I ran lupron 1 mg daily for 12 days as well as enclomiphene 25 my and 10 mg nolva. Labs done at day 14 show LH .3, test levels still pending. Iím thinking Iím pretty damn shut down and not worth pursuing anymore?

14
Iím in my 40s, happy with trt but wanted a little more in terms of lean mass.  Iíve already optimized diet and training.

How bad for ones health to add 150 nandrolone to trt?   Overall goal is health but wanted a little more in gains but donít wanna go crazy (blast and cruise etc)...

15
Testosterone, Hormones and General Men's Health / Got my LH to .7, any hope?
« on: September 29, 2019, 01:08:11 pm »
Long back story, but gist is that I had low T because of a vericocele (TT 388 at age 29)... 41 now.
had it fixed but never really rechecked and years later a hrt clinic doc prescribed trt cause I felt tired and miserable and he said I had no hope going to good natural levels.

I stopped back in 2014, gold turkey and my TT was 144 after 10 weeks.

So Iíve been on trt ever since. I tried so many restarts with different methods, scaly pct, etc.   my TT never got above 40 and LH been zero.

I tried one last restart using enclomiphene 25 daily x 30 days and lupron 1 mg x 2 doses spaced a week apart (day 22 and day 30). My LH went to .7!  (Checked day 31). My TT values I think were wrong, said 1700 (using immunoassay not LC/ms) but I had no hcg or test, and I felt like shit.   Anyway, think thereís any hope at regaining natural levels?

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