« on: March 01, 2018, 09:13:53 am »
JBone if you decide choose the AI route, please give us an update how it works out for you.
This is NOT medical advice. Talk to your doctor first.
SMF - Just Installed!
This section allows you to view all posts made by this member. Note that you can only see posts made in areas you currently have access to.
I have also been suffering with low HPA-Axis activity in the past so I want to offer my own experiences.
I know that doctor Mariano has used low dose SSRI to treat the hypoactivity of the HPA-axis. At least he has done this in the past. Im not sure what is he's stance today.
Here is an excellent write up on how low dose SSRI might help with low cortisol:
I have tried this route myself and I do feel that it works. For me the most important thing was to keep the dose low enough so that you avoid the unwanted side effects.
I was using 2,5mg of escitalopram for over a year and at some point I just felt that I did not need it anymore. I did a slow taper and noticed that my cortisol stayed in good range even without the SSRI. Other thing that made me want to stop it was the emotional numbing that SSRI's often cause.
Other things that I have tried are nicotine patches which improve the activity of the HPA-axis by increasing the release of ACTH from the pituary gland. For me this route is more of an first aid than a long term treatment option. But I do feel that it works. The idea is to use the patches is small portions. For example if you have a patch which has 24mg of nicotine - released in a period of 24 hours - you can cut the patch in quarters and take one quarter a day.
At the moment nicotine patches are more of an nootropic for me than a way to increase cortisol.
Other things that have been a big factor for me are:
- If I dont sleep enough it will eventually lead to a lowered cortisol output. So good sleep hygiene is a must for me
2. Keeping my testosterone dose low enough
- If I go too much past the 1000 ng/dl mark of total testosterone, that will eventually lead to low cortisol also. Keeping the dose low enough and using a EOD injection protocol has worked great.
3. Using HCG
There are anecdotals where people have reported that using hcg with test injections has improved their cortisol levels. I cannot say for certain that this has been the case for me.
4. Thyroid hormones
if you are hypo that can eventually lead to low cortisol levels. So having a healthy levels of thyroid hormones may increase ACTH output. Here's one study that showed just that: https://www.ncbi.nlm.nih.gov/pubmed/2553572
Now I have also tried pregnenolone in the past but I cant say - without labs - that it helped with low cortisol. I do think it improved my sleep a bit.
Thank you for such a great in-depth response!
What would you think if a person's TRT dosage puts them at around 1200 for a day or so and by the end of the week they are around 500-600, is that too much and will cause cortisol suppression?
How long does it take to notice they effects of the low dose SSri? Did you experience any side effects at the beginning of the SSri treatment?
Would you say Hcg is a must if on TRT?
With your current knowledge what would you say is a good morning serum cortisol level?
Im not 100 percent sure yet but I'm fairly certain I took too much arimidex and crashed my E2. I will be getting bloodwork on Thursday to confirm.
So I've been under a lot of stress lately and I think I accidentally took too much arimidex. I haven't felt this awful since before I started trt. I've never experienced brain fog like this. Feels like I have not slept in days even though I'm sleeping through the night. And I have a twitch in my left eye which is driving me absolutely crazy.
Just wondering in the event that it is a crash of E2, is there anything I can do to recover more quickly?
What kind of timeline am I looking at to bounce back?