Instead, it was about a bio-analytical chemist who decided to test synthetic T3 (Cynomel and Cynoplus) as well as the Thailand-made Natural Desiccated Thyroid (NDT) called Thyroid-S, by extracting each tablet with methanol, then diluting and injecting them on an LC/MS system–a sensitive instrument used to detect and identify compounds and molecules in a substance.
And what he discovered and reported is that the thyroid hormones of NDT are tightly bound with thyroglobulin, a large iodine-containing protein….whereas synthetics are bound by nothing. i.e. synthetic hormones are exposed; NDT hormones are protected (until they are released by your digestion). The diagram on this blog post gives you a powerful visual of this reality, but specifically in comparing natural desiccated thyroid with synthetic T4-only. You will see the large mass of thyroglobulin on the left, each containing either T4, T3, T2, T1 or calcitonin within. Then the tiny synthetic hormone on the right, alone.
But is that bad NOT be bound by thyroglobulin?? Possibly yes in the opinion of Peter. As Peter explained: “The [exposed] synthetics might be affected by stomach acids in different ways in different people. Low acid, high acid, various digestive and pancreatic enzymes in varying amounts, bacteria/flora in the stomach and small intestine, all kinds of possibilities here which would vary by the person.” And, he says, that can mean instability!
Peter continues: “Perhaps the thyroglobulin in NDT (and completely missing in the synthetics) is absorbed, or necessary, or utilized, or forms other products during digestion that could affect blood levels of various substances, numerous carrier proteins for example, thereby affecting the results obtained.” And he concludes: “The NDT hormones are bound to thyroglobulin and not available for reaction or breakdown until after they first digested (from Janie: which saliva begins, by the way, even in your mouth). This would be a more stable compound.” His original post is here.http://www.stopthethyroidmadness.com/2012/06/17/chemical-analysis-showing-difference-between-ndt-and-t4-only/