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Messages - VinnAY

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31
I said endos that are familiar with trt.  Not random endos

E, count of endos familiar with TRT is probably less than 50 in this country.  On Crisler - I did consult with him, negative experience, I stopped.

If you had a negative experience with one of the most trust well renowned endos in this country.. then you need to look outside of the medical field for help, lifestyle changes are your only choice

Similar here, watching his videos, seeing his demeanor, very informative, I read and listen but I don't like him, wouldn't let him work on me no matter how good he is.

32
The study refers to the use of anastrozole while on testosterone replacement.

The pituitary negative feedback loop in men is primarily influenced by our estradiol levels, NOT by our testosterone levels. Even if you are on testosterone replacement therapy (TRT), if you lower the estradiol level enough, your normal LH and FSH production will be maintained.

See here: http://www.europeanurology.com/article/S0302-2838(14)00798-2/fulltext/re-coadministration-of-anastrozole-sustains-therapeutic-testosterone-levels-in-hypogonadal-men-undergoing-testosterone-pellet-insertion

and

Quote
In males, estradiol is the main inhibitor of LH production
http://www.merckmanuals.com/professional/genitourinary_disorders/male_reproductive_endocrinology_and_related_disorders/male_reproductive_endocrinology.html

ANd that's why since being on T/Anastrozole/HcG that every LH/FSH I've had has been statistically zero. <sarcasm>

33
1) Men produce about 35-45μg (0.130-0.165 μmol) of estradiol per day
2) 20% of your estradiol is made in the testes
3) Anastrozole can reduce your estradiol/testosterone ratio by up to 77%
4) For men on TRT, anastrozole can reduce your estradiol/testosterone ratio by up to 81%
5) Lowering estradiol with anastrozole results in an increase in LH and FSH in men, as long as there is some residual pituitary-gonadal function.
6) If a boy takes anastrozole while in puberty, it will make him grow taller. This is because reduced estradiol delays the epiphysial closure.
7) Anastrozole does not reduce gynecomastia.
8 ) Daily production and blood level of E2 in men are higher than those in postmenopausal women.
9) Taking anastrozole while on TRT can increase free testosterone, despite not affecting SHBG levels.
10) Taking anastrozole while on TRT can maintain normal LH and FSH levels.

N.B.
Points 9 and 10 were based on 1MG a day of anastrozole. Clearly that is a huge dose. It would be interesting to see a study where the participants were taking a lesser dose, and see how that would affect free testosterone and LH/FSH levels.

Warning: Use of anastrozole 1MG per day in men for up to 12 weeks has been shown NOT to affect bone density in one study, however, the long term use of aromatase inhibitors have a potential serious effect on bone health and metabolism in men.


http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3143915/
http://www.ncbi.nlm.nih.gov/pubmed/16541728
http://www.europeanurology.com/article/S0302-2838(14)00798-2/fulltext/re-coadministration-of-anastrozole-sustains-therapeutic-testosterone-levels-in-hypogonadal-men-undergoing-testosterone-pellet-insertion
http://www.ncbi.nlm.nih.gov/pubmed/15856361

How is 10 supposed to be true...LH and FSH got to 0 on TRT and I assuming TRT = Testosterone.

He's presumably talking anastrozole monotherapy, not with TRT.

Clearly stated "while on TRT".

34
1) Men produce about 35-45μg (0.130-0.165 μmol) of estradiol per day
2) 20% of your estradiol is made in the testes
3) Anastrozole can reduce your estradiol/testosterone ratio by up to 77%
4) For men on TRT, anastrozole can reduce your estradiol/testosterone ratio by up to 81%
5) Lowering estradiol with anastrozole results in an increase in LH and FSH in men, as long as there is some residual pituitary-gonadal function.
6) If a boy takes anastrozole while in puberty, it will make him grow taller. This is because reduced estradiol delays the epiphysial closure.
7) Anastrozole does not reduce gynecomastia.
8 ) Daily production and blood level of E2 in men are higher than those in postmenopausal women.
9) Taking anastrozole while on TRT can increase free testosterone, despite not affecting SHBG levels.
10) Taking anastrozole while on TRT can maintain normal LH and FSH levels.

N.B.
Points 9 and 10 were based on 1MG a day of anastrozole. Clearly that is a huge dose. It would be interesting to see a study where the participants were taking a lesser dose, and see how that would affect free testosterone and LH/FSH levels.

Warning: Use of anastrozole 1MG per day in men for up to 12 weeks has been shown NOT to affect bone density in one study, however, the long term use of aromatase inhibitors have a potential serious effect on bone health and metabolism in men.


http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3143915/
http://www.ncbi.nlm.nih.gov/pubmed/16541728
http://www.europeanurology.com/article/S0302-2838(14)00798-2/fulltext/re-coadministration-of-anastrozole-sustains-therapeutic-testosterone-levels-in-hypogonadal-men-undergoing-testosterone-pellet-insertion
http://www.ncbi.nlm.nih.gov/pubmed/15856361

How is 10 supposed to be true...LH and FSH got to 0 on TRT and I assuming TRT = Testosterone.

35
I've been using the Pharm grade I think 30mg for about a month, one in the morning without anything noticeable (along with 10mg DHEA). Something I did do today, different, was do both of those sublingual holding the capsules under my tongue for 5-10 minutes. Didn't taste bad, but need to do that steady to see if that works better for me.

36
Testosterone, Hormones and General Men's Health / Re: E2 Symptoms
« on: April 08, 2015, 03:12:46 pm »
I feel that I'm very sensitive to E2, it's very hard for me to manage. It may not hurt anything to try and let yourself go up to 30-35 and see what you feel like. Keep notes, I keep a diary and it's mostly E2 symptoms. I'm trying very hard to find a good E2 spot.

37
I flew with my meds recently. Baggy with some ice cubes, double bag the vials with the script labels and only the number of syringes I would need. TSA didn't blink an eye at it, coming or going.

38
At first I assumed that the original poster was asking if anyone has used the chain of clinics called "Low T Center." 
I started out using them because my primary care doctor would not treat me. I was pleased with their service. I saw a PA, not a doctor on most of the weekly visits and a doctor about twice a year. They were knowledgeable and attentive. They had attractive young women at reception and giving the shots. I guess that is a marketing thing. They did testing every 6-8 weeks. They worked with my insurance. The only reason I changed was to do self injection, which they don't support and the weekly trips took a big chunk out if my day when my work location changed.

I will echo 100% of what you say here about Low T Center.

39
Total T-698
FreeT- 28.2 pg/ml
SHBG- 16.3 nmol/L
Estradiol- 47pg/ml  lab says Roche eclia methodology
DHT- 34ng/DL
Prolactin- 12.6 ng/DL

I will post more later, busy at work. Insomnia and night sweats have kicked in again after dropping to 40mg e3d, sub q still.  I am at a loss as to what to do!! Should I dose more frequently with way less? I welcome all advice!! Thank you!! Obviously Estradiol is high. This was at 50 mg subq E3d and are trough levels!!

....told ya so.

This post isn't helpful.

Guys, try to keep it in line please.  We're here for support.

Oh no it's exactly helpful, it's exactly what he was told when he said he was stopping and starting injections on a daily basis and IS helpful to others that think they can manipulate dosing on the fly like he did. As far as being supportive, he's causing his own problems and, well, here he is... :o

40
Testosterone, Hormones and General Men's Health / Re: PT-141 Log
« on: April 01, 2015, 05:11:41 pm »
I'm out of 141 right now, the last month or two but maybe I'll give it another whirl @ 2mg and see how it goes.

41
Yeah, give it more time.  Later you can try injecting every other day with a slightly lower dose.  But for now keep with what seems to be working.  This is good news!  You know your hunch about high estradiol was right.

Heck, you might (later) add indolpex DIM and/or Zinc to cut down your E2 even further.  First I'd give it a month or so at this lower dose.  If your trough is that high on T, you might even consider dropping the dose further -- but first give it a month to stabilize.

698 in a trough is not high. It's just not.

42
Total T-698
FreeT- 28.2 pg/ml
SHBG- 16.3 nmol/L
Estradiol- 47pg/ml  lab says Roche eclia methodology
DHT- 34ng/DL
Prolactin- 12.6 ng/DL

I will post more later, busy at work. Insomnia and night sweats have kicked in again after dropping to 40mg e3d, sub q still.  I am at a loss as to what to do!! Should I dose more frequently with way less? I welcome all advice!! Thank you!! Obviously Estradiol is high. This was at 50 mg subq E3d and are trough levels!!

....told ya so.

43
35 isn't all that high, maybe a little elevated. Are you having symptoms or problems right now that you feel are E2 related?
Re: capsules, you can't break those open and get the powder out, weigh it on a scale and divy it up? You're so close though with that 35!
I'd definitely support trying the DIM over AI, the very little support you need I think that's option #1.

44
I don't think and Ive thought a lot about it but I don't think I've had much REM sleep wood or morning erections in 43 years. I'm not having them now and I do suffer some ED, alone and with a partner. PDE5i do work but not 100% for me, I don't like Cialis, I do better with Viagra. But I know if it's between erections and an injection in my dick, I'm not going that far.

45
Curious change in just one day I'd say that that's bunk but you're seeing it time and again, it's interesting but I think the gel is attributed to better DHT levels maybe that's something to look at.

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