Anecdotally...maybe...but I've had serious negative reactions at >25mg oral daily dosing. I'm taking ~12mg oral daily and not experiencing any negative sideeffects. I have been making notes in my TRT diary of RSW of 2-3 nights per week, though so I just say it's anecdotal and I can't directly correlate the two.
Negative reactions? What do you mean?
E2 spike, most likely. Irritable, aggressive, depressed, very pronounced symptoms, the kind of reaction of "if youre looking for a fight today, you're about to get one", that sort of thing. I'd stop taking it and 36hrs return to my normal stable self. I started and stopped several times and it was always the same result, not backed by Estradiol testing though. As little as 25mg oral daily was not something that I could cope with.
DHEA-S i've tested low with 160 (70-495) so I do want to supplement it I just had to cut it way back from this recommended 50mg (or more).
My worst experieince on it was pre-TRT when I was taking ~100mg, I was in a bad place back then that was made a lot worse by DHEA orally.