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Testosterone, Hormones and General Men's Health / Re: Clomid success story?
« Last post by seppuku on April 16, 2021, 07:43:34 am »

Have you given any thought to switching to enclomiphene now that it's somewhat available?

Exactly what i was thinking. Currently waiting for mine to arrive (as i mentioned on Nelson's site).
Testosterone, Hormones and General Men's Health / Re: Clomid success story?
« Last post by Cataceous on April 14, 2021, 06:53:02 pm »
Glad to learn you're doing well. I remember your earlier struggles and have wondered how things were and if you were still on Clomid.

Have you given any thought to switching to enclomiphene now that it's somewhat available?
Testosterone, Hormones and General Men's Health / Clomid success story?
« Last post by Nocturne on April 14, 2021, 03:44:44 pm »
Hey all - itís been a long time.
Just wanted to drop in and give some of the newer people some encouragement.  When I first came here in 2015, I was a complete wreck.  My T was in the low 100s, I was completely impotent (which came on all of a sudden around April of 2015).  It was a long road getting better and I learned along the way that I have a genetic abnormality that has given me very premature heart disease (I was 41 in 2015).
But!  With Clomid (and a touch of Anastrazole), I was able to get my T levels into the 500s (and sometimes above that, as high as the 700s).  It took over a year, and the help of 2.5 mg of Cialis a day, but my erections returned to more or less normal (even strong on occasion), and I enjoy regular sex with my wife without a LOT of worrying (that never goes away entirely, Iím afraid).  In many ways, my nightmare has been over for a while.  I owe a lot to the good people here (and over at franktalk.org) for listening and giving support and advice when I really needed it.  There is hope!
Testosterone, Hormones and General Men's Health / Re: I'm back.
« Last post by Cronos on April 13, 2021, 07:21:40 pm »
Happy to see you back Cronos. The human psyche is intriguing. I actually find myself avoiding this forum, to some extent, because it brings sadness back to the surface from Peakís passing. The fact that two of my fondest ďforum palsĒ (Peak and Dr Crisler) passed within a year of each other has had a real impact on me for sure. I get it.

As an FYI, you can always follow-up early including early labs if things are amiss. Further, you can always follow-up directly with me if needed...though Iím typically booked out a little farther than the rest of my team. All the best my friend.

Here lately when I have had time I have gone back through a lot of Peaks old threads and man did he have some great insights. He really did want to help people. He gave us so much of his time and I do miss him.

I would like to say though thank you and your team so much for doing what you do. You really are a god send for a lot of us. So again thank you.

As far as following up early I think I figured it out for right now as I put in the above earlier post. I just have to take my AI earlier before I "peak" haven't changed doing anything from what I was prescribed because I don't like going rogue. But making sure I take it earlier has helped a lot.
Testosterone, Hormones and General Men's Health / Re: I'm back.
« Last post by Cronos on April 13, 2021, 07:14:11 pm »
Sorry been busy busy. Well for the time being I think I found a sweet spot by timing things a little differently but sticking with the protocol as well. So still injecting 70mg twice a week sunday/Wednesday and hcg anastrozole Tuesday/Thursday. Because of my job generally I'm going until at least midnight if not a little later so I have started taking my anastrozole around that time. Midnight 1am something like that. It has proved to really help me out. Everything seems to be trending well for me doing that.

I still agree with you Cataceous though. Definitely going to ask about lowering dose at follow up depending on what my labs say but I have a feeling I know what they're going to show. Plus I just don't like depending on an AI. Would rather be on Testosterone and HCG alone without the AI.

Testosterone, Hormones and General Men's Health / Re: I'm back.
« Last post by Cataceous on April 12, 2021, 02:04:33 pm »
A few anecdotes from over at EM:

I too started at too high a dose when starting injections, 150mg/week dosed E3D. It was living Hell having to reduce dose and go through withdrawal getting it right from there over the course of many months. In retrospect if I was to do it again, I would have started on about 80mg/week dosed every 2 or 3 days, and if inadequate boost 2mg EOD at 6-8 week intervals with labs at each stage until I felt good.[R]

Dropped from 70mg every 3.5 days to 60mg every 3.5 days to 16mg every day (140mg total per week to 120mg total every week to 112mg total every week). Putting aside improved lab results, I felt better each and every time the dose was lowered. I am where I should be.[R]

I am 5'10" 155 lbs and I get my total T in the 800 range with about 100mg per week split into 3 doses. Anything above that and I don't feel great. It will take months not weeks to tweak your protocol and achieve optimum results. But it is worth it. [R]

TRT patient feeling better after lowering my prescribed dose [R]

I'll mention that selegiline is an alternative to Dopa-Mind and Dopa-Bean. In addition, *small* amounts of phenethylamine aka PEA work synergistically with MAO-B inhibitors such as selegiline.

In the brain, phenethylamine regulates monoamine neurotransmission... ... it also acts as a neurotransmitter in the human central nervous system.
Phenethylamine, being similar to amphetamine in its action at their common biomolecular targets, releases norepinephrine and dopamine. Phenethylamine also appears to induce acetylcholine release via a glutamate-mediated mechanism.

It,s 2021, is there anymore advice on this subject.
The "S" in SERM stands for "Selective". This means you can have quite different results depending on the type of estrogen receptor. Check out this link: https://en.wikipedia.org/wiki/Template:Tissue-specific_estrogenic_and_antiestrogenic_activity_of_SERMs
Every SERM listed is agonistic in bone. With SERMS you are not going to experience all the negative side effects of low estrogen. There are still valid concerns, of course. For example, enclomiphene is antagonistic of estrogen receptors at the hypothalamus and other areas of the brain. There is speculation that this could harm libido due to estrogen's important role therein. But it's not clear-cut. Anecdotally some guys, such as myself, maintain or increase libido while using this drug.
You're gonna have the same end result whether you're blocking production of e or blocking the receptor. I've felt that and it's no fun, extreme joint and muscle pain.

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