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Testosterone, Hormones and General Men's Health / Re: TSH of 3.6
« Last post by Flyingfool on Today at 02:58:33 am »
TSH as I may have said is nearly useless. You must get both free T4 and free T3 to really get an idea of what your thyroid status is. Combined with symptoms to determine what to recommend or consider.
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Gotcha. My Free T3 and Free T4 are at the top of the ranges, so they look fine. But RT3 has recently tested at the top of the range too. What can high RT3 indicate? Wonder if the RT3 can indicate some insulin resistance/fatty liver, for example.
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Very interesting read.  Thanks for sharing.  I wish you the best.

A
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I suspect the enclomiphene would swamp the effects of the Kisspeptin as it pushes LH in to overdrive at even low doses.
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This is not the case with concurrent TRT; very few men achieve HPTA activity with SERMs when there is significant exogenous testosterone present. Negative feedback from both androgens and estrogens suppresses kisspeptin production in the hypothalamus, which in turn knocks out GnRH. In theory, supplying exogenous kisspeptin bypasses the androgenic suppression at the hypothalamus, allowing endogenous GnRH production. But at the pituitary there is still suppression by estrogens. It is this latter that is being targeted by enclomiphene. The enclomiphene is thus complementary to exogenous kisspeptin.

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Your Enclomiphene may have some estrogenic effects, well thats to say you possibly cant guarantee the purity of the enclomiphene that is currently available.
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If the source is Tailor Made then it's fine.

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If money was no object I would go for E2, total T, shbg, LH, Albium plus FSH tests as this would give a fuller picture but having so many things added in at this stage it might be hard to know whats effecting what.

GnRH would be the most useful to know, if practical. If it's still suppressed then it would cast doubt on the protocol. But if present it could mean that the pituitary just needs more time to ramp up production of LH.
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Testosterone, Hormones and General Men's Health / Re: TSH of 3.6
« Last post by Bravo5 on October 24, 2020, 06:55:06 am »
Despite what they say about the upper range of tsh. Anything over 3 is clearly need for thyroid medication.
My TSH was about 3-4.5 mostly and I tried all kinds of medication for it. Best was to get amount of T3/T4 supplements to its natural ratio (of I think 1/13 but not sure anymore) with three times daily administration.

If you don't have another choice sure, take medication but please don't underestimate the value of a functioning feedback-loop.

I feel better off of any medication.
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Testosterone, Hormones and General Men's Health / Re: Anyone have luck with Kisspeptin?
« Last post by ghce on October 24, 2020, 04:56:02 am »
Update:
Day 30 of 100 mcg kisspeptin 10 daily with my normal trt dose (14mg daily).
Donít feel much different than day 16 where my LH was zero.  Still feel tired, somewhat depressed in a sense.  Last 3 weeks felt like I was coming down with a cold but never got it.  Testicles may be a little bigger but I didnít have sex in a week as busy and wife is having GI issues.
Not sure what to do.
Press on but if this is how I am going to feel, I felt much better on trt plus hcg.   Is it even worth continuing because even if my LH is elevated, I feel so fatigued and itís not worth it.  Or maybe I feel better in the next few weeks?
Iím a professional (not sports) so I know my performance at work and at home with my kids is not 100%.  Any insights appreciated, esp Cat

Do you have any blood test levels indicating an increase in LH and FSH at around the day 30 point?

I did not get labs cause my thoughts were that even if my LH is high, whatís the difference if I feel like crap?

Fair comment, though with the labs it may provide an insight as to what other additions and treatments may ameliorate the crap feeling.

Agree, Iíve added enclomiphene 25 mg every 3 days.  Iím going to check labs next week just to see where Iím at.  Maybe Iíll just check LH?   

I suspect the enclomiphene would swamp the effects of the Kisspeptin as it pushes LH in to overdrive at even low doses.
Your Enclomiphene may have some estrogenic effects, well thats to say you possibly cant guarantee the purity of the emclomiphene that is currently available.

If money was no object I would go for E2, total T, shbg, LH, Albium plus FSH tests as this would give a fuller picture but having so many things added in at this stage it might be hard to know whats effecting what.
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Update:
Day 30 of 100 mcg kisspeptin 10 daily with my normal trt dose (14mg daily).
Donít feel much different than day 16 where my LH was zero.  Still feel tired, somewhat depressed in a sense.  Last 3 weeks felt like I was coming down with a cold but never got it.  Testicles may be a little bigger but I didnít have sex in a week as busy and wife is having GI issues.
Not sure what to do.
Press on but if this is how I am going to feel, I felt much better on trt plus hcg.   Is it even worth continuing because even if my LH is elevated, I feel so fatigued and itís not worth it.  Or maybe I feel better in the next few weeks?
Iím a professional (not sports) so I know my performance at work and at home with my kids is not 100%.  Any insights appreciated, esp Cat

Do you have any blood test levels indicating an increase in LH and FSH at around the day 30 point?

I did not get labs cause my thoughts were that even if my LH is high, whatís the difference if I feel like crap?

Fair comment, though with the labs it may provide an insight as to what other additions and treatments may ameliorate the crap feeling.

Agree, Iíve added enclomiphene 25 mg every 3 days.  Iím going to check labs next week just to see where Iím at.  Maybe Iíll just check LH?   
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Testosterone, Hormones and General Men's Health / Re: Anyone have luck with Kisspeptin?
« Last post by ghce on October 23, 2020, 06:17:01 am »
Update:
Day 30 of 100 mcg kisspeptin 10 daily with my normal trt dose (14mg daily).
Donít feel much different than day 16 where my LH was zero.  Still feel tired, somewhat depressed in a sense.  Last 3 weeks felt like I was coming down with a cold but never got it.  Testicles may be a little bigger but I didnít have sex in a week as busy and wife is having GI issues.
Not sure what to do.
Press on but if this is how I am going to feel, I felt much better on trt plus hcg.   Is it even worth continuing because even if my LH is elevated, I feel so fatigued and itís not worth it.  Or maybe I feel better in the next few weeks?
Iím a professional (not sports) so I know my performance at work and at home with my kids is not 100%.  Any insights appreciated, esp Cat

Do you have any blood test levels indicating an increase in LH and FSH at around the day 30 point?

I did not get labs cause my thoughts were that even if my LH is high, whatís the difference if I feel like crap?

Fair comment, though with the labs it may provide an insight as to what other additions and treatments may ameliorate the crap feeling.
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I am on a fairly good-sized TRT dose of generic Androgel.  Cyclo shots were a huge disappointment to me because of the lack of frequency I was allowed to have them.  I tried testopels and I didnít like them.  The highest my total testosterone has ever been that I have recorded with labs is like 458 ng/dL and that is WITH TRT. 

I have had low testosterone since I was 14 and started TRT at 15 years old because I was constantly anemic, couldnít seem to progress in sports like my friends, etc.  My total T without TRT while being off TRT for 5 months was 180 ng/dL in the morning within 1-2 hours of waking up with at least 7.5 hours of sleep.  That level is WITH psychotropic meds.  My total T levels off psychotropics was around 210-220 ng/dL in the morning. 

I am nearly 25 in less than a month and have spent a decade almost on TRT.  Iíve never had my estrogen levels checked nor have I ever tried an aromatase-inhibitor nor have I ever been allowed to try HCG.  I live in a small town with super strict doctors and even the endocrine/urology clinics in nearby towns are unwilling to do much for me except urology wants to offer me implants for my testes to make them look bigger which I have declined because I donít want to consider that option yet considering Iím not even 25. 

Despite my low T, I used to be squatting 295+ Pounds with a back squat, was benching around 200 lbs, could do up to about 75 pounds on shoulder press, did ab workouts almost daily, went for walks several times a week, and mixed in some running/biking with lifting at least 2 times a week (minimum).  EVEN WITH ALL THAT, my total T levels after losing 46 pounds and improving my diet were still only like 448 ng/dL total. 

My ďbestĒ levels are obviously other peoplesí definition of ďlowĒ levels and they are low, yes.  But, I have worked extremely hard at improving that.  Iíve done cortisol and thyroid testing and it is all normal and of no concern.  At 169 pounds, I still had high cholesterol despite a fairly healthy diet with fruits and vegetables and exercising around 4-5 times a week with walking/lifting/biking. 

Thatís my story, yet I wish it was more of a ďsuccessĒ one.  When I have a better financial backbone, Iím hoping to try to maximize my endocrine health.  Iíve also wanted a personal trainer and a solid diet possibly with the help of a nutritionist.  Iíve been spending some time (whenever I have free time) trying to learn to cook healthier options and get all my macros in without excessive trans/sat fats, sodium, cholesterol, etc. 

Iím only about 5Ē7í or 5Ē8í with shoes.  Almost all my visceral fat goes right to my abdomen.  I donít drink alcohol literally ever (by choice) and I try to follow a plant-based diet with the ďoccasionalĒ exception of eating out at a restaurant(s) or ordering pizza.  I havenít had issues with gluten at all, but dairy I think Iím sensitive to and it makes me tired, bloated, lethargic, etc. 

10
Update:
Day 30 of 100 mcg kisspeptin 10 daily with my normal trt dose (14mg daily).
Donít feel much different than day 16 where my LH was zero.  Still feel tired, somewhat depressed in a sense.  Last 3 weeks felt like I was coming down with a cold but never got it.  Testicles may be a little bigger but I didnít have sex in a week as busy and wife is having GI issues.
Not sure what to do.
Press on but if this is how I am going to feel, I felt much better on trt plus hcg.   Is it even worth continuing because even if my LH is elevated, I feel so fatigued and itís not worth it.  Or maybe I feel better in the next few weeks?
Iím a professional (not sports) so I know my performance at work and at home with my kids is not 100%.  Any insights appreciated, esp Cat

Do you have any blood test levels indicating an increase in LH and FSH at around the day 30 point?

I did not get labs cause my thoughts were that even if my LH is high, whatís the difference if I feel like crap?
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