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If the half-life of hCG is about 36 hours then it takes maybe a week to ten days for it to be pretty thoroughly eliminated. This doesn't address lingering effects, which could last longer, particularly if there's been more HPTA suppression, which then takes time to reverse.

I think your plan is reasonable under the circumstances, but it's likely not directly addressing any underlying issues; it's mainly giving them more time to resolve naturally.
Are you reffering to the nolva + proviron plan? Also do you actually think that if i drop everything and let my body heal on its own, eventually everything will be back to normal?
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Update :

I'm still running 12.5mg of Clomid every 2 days, now I'm starting to try every 3 days to see if I can keep high testosterone with this method while reducing my Estradiol.

My sperm results after running Clomid are way better, even though it's still not very good.

Having a very little beard, I've also noticed that since running Clomid my beard is growing more.

Regards.
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If the half-life of hCG is about 36 hours then it takes maybe a week to ten days for it to be pretty thoroughly eliminated. This doesn't address lingering effects, which could last longer, particularly if there's been more HPTA suppression, which then takes time to reverse.

I think your plan is reasonable under the circumstances, but it's likely not directly addressing any underlying issues; it's mainly giving them more time to resolve naturally.
4
Since November 2018 only 2 things gave me brief relief from ed and low libido symptoms. Nolva when taken for 4 weeks at 10mg eod but it only lasted for a couple of days. I guess it either raised e2 after that or shbg. and the second is proviron a couple of months ago. So i think i should take these 2 for 4 weeks so that i can raise free t by increasing lh with nolva and keep shbg low with proviron. I know its a little suppresive but i dont think it will have that effect along with nolva. If and when i get that symptom releif i'll do a complete bloodwork to see what my labs are when i feel good.
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Clomid probably raises SHBG in two ways, both related to estrogenic effects on the liver. First there's the direct increase in estradiol stimulated by higher testosterone and LH-stimulated intratesticular aromatization. Second, the zucomiphene isomer is estrogenic and probably acts directly on the liver. As an aside, I've been taking enclomiphene, the other isomer of Clomid, and have not seen a change in SHBG.

An aromatase inhibitor has no effect on zuclomiphene, limited effect on intratesticular aromatization, and a significant effect on other systemic aromatization.

Tamoxifen does not have an estrogenic component, but otherwise acts similarly to Clomid.

It wouldn't hurt to look at DHT, IGF-1, also progesterone and thyroid hormones (fT3, fT4, rT3) if you haven't already. I'm not expecting to see anything too out of line. There are way too many guys in this position, with good basic numbers but still having low libido and other problems. Unfortunately I don't think there are widely available tests for kisspeptin levels. Maybe in time more doctors will prescribe kisspeptin-10 as a stimulation test in cases where nothing else is obviously wrong.

Yes but for some reason clomid raises ejaculation volume more than nolva. Anyway i'll do bloodwork tommorow (only e2) to see if i crashed them. And then nolva, or clomid with aromasin for 4 weeks (and maybe some proviron to keep gf happy). After that i'll wait for 4 more weeks and do bloodwork with all the extra you mentioned, plus free T no matter how inaccurate it may be. Do you know how long for hcg to clear my system cause in 2 weeks i am going on vacation with gf and i dont want to be crushed at that time. Should i keep taking it until then at lower dose along with a serm or it will have cleard my system before that if i stop now? I have taken about 13000 ius in total.
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TN1989

My observation and I could be wrong. Is that you are changing too many things, much too fast.

I understand the incredible frustration with lack of results. But with hormones, they are all so inter-related and sensitive, low and slow changes one at a time seems to be the best idea, but it can be painfully, frustratingly and glacially slow process.

You are right. I do. Its just so frustrating. It has severely affected my job performance and relationship with gf. And when your bloodwork seems ooptimal it is even harder to deal with. If i had low t it would be more simple. Try a couple of restarts and if they dont work go to trt. But as i said you are right and i need to deal with it more mature.
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Clomid probably raises SHBG in two ways, both related to estrogenic effects on the liver. First there's the direct increase in estradiol stimulated by higher testosterone and LH-stimulated intratesticular aromatization. Second, the zucomiphene isomer is estrogenic and probably acts directly on the liver. As an aside, I've been taking enclomiphene, the other isomer of Clomid, and have not seen a change in SHBG.

An aromatase inhibitor has no effect on zuclomiphene, limited effect on intratesticular aromatization, and a significant effect on other systemic aromatization.

Tamoxifen does not have an estrogenic component, but otherwise acts similarly to Clomid.

It wouldn't hurt to look at DHT, IGF-1, also progesterone and thyroid hormones (fT3, fT4, rT3) if you haven't already. I'm not expecting to see anything too out of line. There are way too many guys in this position, with good basic numbers but still having low libido and other problems. Unfortunately I don't think there are widely available tests for kisspeptin levels. Maybe in time more doctors will prescribe kisspeptin-10 as a stimulation test in cases where nothing else is obviously wrong.
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Testosterone, Hormones and General Men's Health / Re: Jatenzo
« Last post by Flyingfool on August 12, 2020, 07:37:32 pm »
The hormone clinic my wife goes to for testosterone and hormone treatment almost exclusively uses pellets. They also claim this to be the far and away best method with moat effect and least side effects.

The clinic also recommends pellets for men T replacement as well.

If I get to the point of getting T replacement. I think I would try to use a combination of pellets and T cream to scrotum.

The pellets would offer steady baseline T level with daily nearly constant dissolution into the blood. While the cream would attempt to replicate the more natural diurnal effect daily (or few times a week) leak boost for men. It seems topicals also help with DHT and libido for many men.  Would have to experiment with cream amount for daily use, or maybe apply EOD or 3 days a week. Whatever works for the individual.

The pellets are inserted once every I think for men 3 months or so. And cream would be as needed. So fairly easy compliance and. No need to inject self frequently.
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TN1989

My observation and I could be wrong. Is that you are changing too many things, much too fast.

I understand the incredible frustration with lack of results. But with hormones, they are all so inter-related and sensitive, low and slow changes one at a time seems to be the best idea, but it can be painfully, frustratingly and glacially slow process.
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This is still bad news. At best it might be a while before they can get approval. And if they do have to get a new license, that cost to achieve will be high which will reflect ultimately in a higher price to the end user.   But at least it will be an option.

This is crazy. To make them prove it is safe etc for something the FDA has already approved and safely used for nearly 50 years!  Makes me think there is another agenda at play here. I have my idea but Iím sure many would call it a conspiracy theory.

My question is. If there IS a conspiracy, that doesnít make it a theory. It does make it sinister.
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