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Testosterone, Hormones and General Men's Health / Re: Clomid and prolactin
« Last post by guil70 on February 25, 2021, 12:33:22 am »
Here it is,

prolactin  15.8 ng/mL          4.0-15.2


What would be the optimal value?. My next appointment will be in three months since they say " I am fine", what can I do?
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Testosterone, Hormones and General Men's Health / Re: Clomid and prolactin
« Last post by Cataceous on February 24, 2021, 02:58:36 pm »
Other than prolactin and estradiol, what are some of the other estrogenic effects of Clomid?

Are you referring to symptoms or mechanisms? Another symptom of the higher estrogenic action is higher SHBG.

There are at least three mechanisms of action: Higher testosterone production means higher estradiol; higher LH probably means a higher rate of aromatization in Leydig cells; the zuclomiphene isomer acts directly as an estrogen.
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Testosterone, Hormones and General Men's Health / Re: Clomid and prolactin
« Last post by Gef on February 24, 2021, 06:32:20 am »
Other than prolactin and estradiol, what are some of the other estrogenic effects of Clomid?
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I have my doubts about Proviron/mesterolone in your case. It's a DHT-based steroid and you say your DHT levels are on the high side already. I would try to normalize testosterone levels via injections and then give things some time.

Do test estradiol when you can. If it's on the low side then that would be another reason for adding hCG to your protocol.
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Hi Cataceous,

thank you very much for your helpful answer. We would like to plan for children, but I am far from that for now with my problems. It is first important that I am able to get erections again. Everything else comes after that. SHBG is actually quite high in my case (see above), so maybe that is already the problem. I will also ask my doctor if it makes more sense to go for T-injections instead of T-gel. I really don't feel any androgenic effect at all. Neither libido nor erections. HCG I will also bring up, I am still waiting for a call back from my doctor.

Fishoil I bought currently and I have been taking it for a few days. Hopefully that and my almost daily jogging laps will help get the lipids back under control. They have been this high for me for years, even though I am really slim and have no other risk factors.

I do not live in the USA (Germany). Finding good endocrinologists here is very difficult.

Unfortunately, I have not currently had an estradiol value determined, but I will do so later. Could it help if I try to take Proviron? I have heard a lot of good things about this for men who feel no effect from TRT alone.

Thanks!

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Testosterone, Hormones and General Men's Health / Re: Micro dose hCG monotherapy
« Last post by Cataceous on February 23, 2021, 12:13:58 pm »
The effect of hCG on testosterone is nonlinear, so estimating where testosterone will be with half as much hCG may be an exercise in futility. An odd feature of hCG is that as doses are raised, testosterone production initially increases as well, but at some point as hCG goes up further testosterone production declines. Chances are your doses are all below this threshold, which could be as high as 1,000 IU EOD [R]. In any case, the simplest assumption is that there is some linearity in the lower range of hCG doses, in which case your predicted testosterone from 375 IU hCG E3D is 400 ng/dL. But treat this as only a guess.
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Testosterone, Hormones and General Men's Health / Low cortisol
« Last post by StephCurryFtw on February 23, 2021, 07:15:36 am »
My AM cortisol came back low. Is this concerning being on TRT?  I checked through Defy. 
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Testosterone, Hormones and General Men's Health / Re: Micro dose hCG monotherapy
« Last post by Forty2 on February 23, 2021, 01:50:49 am »
When refrigerated, rehydrated hCG should stay fairly potent for at least one to two months. There is conflicting information about whether hCG can survive a freeze-thaw cycle. It might be worth freezing the excess if the alternative is throwing it away. Then you have the option of trying it later to see if it is still potent.

I think realistically you're more likely to see a net loss of testosterone as a long-term result of this experiment. The first few doses of hCG may indeed give you a boost, as it supplements your existing LH. But the non-pulsatile nature of the hCG makes it more suppressive than LH, likely leading to less testosterone than at baseline as time goes on. Only at full replacement doses of hCG are you likely to see higher testosterone.

I don't know if this would work either, but a slightly better bet is to try infrequent hCG doses, e.g. once a week. This is almost five half-lives of hCG, allowing it to mostly clear out before the next dose. Maybe this would keep the suppression in check, giving you extra testosterone in the first few days after each injection. Of course it could also lead to below-baseline testosterone in the final days before the next dose, as well as lower average levels. Only experimentation would tell.

In any case, it makes sense to keep the starting doses low, 100-300 IU per injection. Suppressive effects can take weeks to fully manifest, so I wouldn't test serum levels until at least a month in.

My concern is exactly what you mentioned i.e. that I may see a net loss of testosterone in the long term on such a low dose of hCG.
I don't see the benefit of taking it for such a short time and then stopping it, so I may abandon this idea.
Previously I tried hCG monotherapy at a dose of 500iu eod for 1 month, which boosted my TT from 320 to 800. It did make me feel significantly better, however, I experienced sensitivity in the nipple area and a hot flushed face.
I'm now considering trying hCG monotherapy again at a lower dose of perhaps 375iu every 3 days. Are you able to estimate approximately how high my TT would be on this dose?
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I don't know how likely it is that the previous treatments contributed to your problems, but it's at least possible. Given that there's no obvious target for further treatment it at least makes sense to take a break and see how you feel in a few months. These things can move surprisingly slowly. For example, regaining sperm production after steroid abuse can take over a year.
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Testosterone, Hormones and General Men's Health / Re: Clomid and prolactin
« Last post by guil70 on February 21, 2021, 11:49:48 pm »
Thank you, after hear of cabergoline from you for the first time all what I have read from it is good, really very good. I will read about Selegiline as well. I really need a fix, something is not good in me lately. I am not sure if Clomid daily use was better for me than this every other day scheme no matter the estradiol decreasing, my testosterone went down from 655 ng/dl to 510 ng/dl.
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