« Last post by Cataceous on April 02, 2021, 02:08:56 am »
I use Defy myself and frequently recommend them, but I do find myself diverging from them philosophically on some of these dosing issues. I think that if guys can't feel good on physiological doses then higher doses are at best partly compensating for other problems—such as the disruption of upstream hormones—and at worst introducing a variety of side effects. With physiological doses of testosterone an aromatase inhibitor shouldn't usually be needed. And I don't understand the use of one before estrogen levels are even known. I'll concede that use of hCG can significantly increase estradiol for many men. I had this problem and in the end never felt like I could get things right, with or without an AI. That's why I eventually abandoned hCG in favor of a complex method of restoring the upstream hormones.
Admittedly there is bias involved when I rely on my experiences and those of guys on the forums. These may be over-representing the frequency at which troubles are encountered under TRT; the happy guys aren't going to be here complaining. But I continue to think that for best health overall we want to be mimicking the hormone levels of average healthy young men, and not the extreme outliers.