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Author Topic: Testosterone (TRT) Causes Calcification of the Arteries?  (Read 3115 times)

ghce

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Testosterone (TRT) Causes Calcification of the Arteries?
« on: May 17, 2016, 11:15:38 pm »
Most of the time I read about guys they been on it for less than 10 years.. I'm 26... if lived to be 86 I would need to be on it for 60 years. This really trips me out....are there any guys who have been on it for 40... 30.. years? How has that worked out for you?

I asked a similar question earlier.    I've been on TRT now for 3 years, and I expect to stay on this for the rest of my life.    I'm in my late 50's.    I'm concerned about the consequences of having what could be an unnatural high T as I age; and it's impact on the aging process.     

Recently heard an article on the radio station (Tech and medical slot) which has found that large testosterone levels potentially causes calcification and hardening in the artery walls of older males ie increased morbidity figures than those on TRT treatments.
http://medicalxpress.com/news/2016-04-links-heart-disease-testosterone.html
« Last Edit: May 19, 2016, 08:31:30 pm by PeakT »
Age:60, Height 6' 3" weight 100KG
2014 Androderm Patches
2014-2016 Oral Andriol 160mg Daily
June 2016 Clomid/Serophene 12.5mg EOD
September 2016 no TRT all natural and supplements for the time being
February 2017 Testosterone cream 100mg daily

Sept 2016
Testosterone   8.2 nmol/l   9-38
Free Testosterone   239 pmol/l   L   250-800
SHBG:  14    nmol/L   9-60
Free Androgen index   586   >400
Oestradiol    112   pmol/L    <190
LH    2.6 IU/L Adult male   2 - 9 IU/L
FSH  1.4 IU/L Adult male L2 - 12 IU/L

22 November
T 6.8  nmol/L ( 9-38 ) L

March 2017
Testosterone:   45.0  nmol/L ( 9-38 ) H ( 1,323 ng/dl )
Free Testosterone:   1512  pmol/L ( 250-800 ) H
SHBG:   17  nmol/L ( 9-60 )
Plasma IGF-1:   227 ug/L ( 55-198 ) H
Plasma cortisol:   434 nmol/L ( 0600-1000 hrs 170-500 nmol/L )
HbA1c:   36 mmol/mol ( 20-40 )
LH:   <0.1 IU/L
FSH:   0.1 IU/L
DHT Plasma Dihydrotestosterone:   7455   pmol/L ( 223 ng/dl ) 
Reference Range Adult males  1000-6000 pmol/L

curious

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Re: Testosterone (TRT) Causes Calcification of the Arteries?
« Reply #1 on: May 18, 2016, 12:55:19 am »
Most of the time I read about guys they been on it for less than 10 years.. I'm 26... if lived to be 86 I would need to be on it for 60 years. This really trips me out....are there any guys who have been on it for 40... 30.. years? How has that worked out for you?

I asked a similar question earlier.    I've been on TRT now for 3 years, and I expect to stay on this for the rest of my life.    I'm in my late 50's.    I'm concerned about the consequences of having what could be an unnatural high T as I age; and it's impact on the aging process.     



Recently heard an article on the radio station (Tech and medical slot) which has found that large testosterone levels potentially causes calcification and hardening in the artery walls of older males ie increased morbidity figures than those on TRT treatments.
http://medicalxpress.com/news/2016-04-links-heart-disease-testosterone.html

The study you are referencing is in mice, not humans. Further, it is not looking at endogenous versus exogenous testosterone but rather testosterone as a whole and makes no mention of older males. In my personal opinion, and I am not a doctor, I think if testosterone was inherently dangerous for the heart you would see young men developing cardiovascular disease.
« Last Edit: May 19, 2016, 08:29:47 pm by PeakT »

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Re: Testosterone (TRT) Causes Calcification of the Arteries?
« Reply #1 on: May 18, 2016, 12:55:19 am »


ghce

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Re: Testosterone (TRT) Causes Calcification of the Arteries?
« Reply #2 on: May 18, 2016, 01:05:13 am »
Yes you are correct, not wishing to scare monger at all, but I feel that a study of this sort will lead to some more in-depth studies in the human population
« Last Edit: May 19, 2016, 08:30:50 pm by PeakT »
Age:60, Height 6' 3" weight 100KG
2014 Androderm Patches
2014-2016 Oral Andriol 160mg Daily
June 2016 Clomid/Serophene 12.5mg EOD
September 2016 no TRT all natural and supplements for the time being
February 2017 Testosterone cream 100mg daily

Sept 2016
Testosterone   8.2 nmol/l   9-38
Free Testosterone   239 pmol/l   L   250-800
SHBG:  14    nmol/L   9-60
Free Androgen index   586   >400
Oestradiol    112   pmol/L    <190
LH    2.6 IU/L Adult male   2 - 9 IU/L
FSH  1.4 IU/L Adult male L2 - 12 IU/L

22 November
T 6.8  nmol/L ( 9-38 ) L

March 2017
Testosterone:   45.0  nmol/L ( 9-38 ) H ( 1,323 ng/dl )
Free Testosterone:   1512  pmol/L ( 250-800 ) H
SHBG:   17  nmol/L ( 9-60 )
Plasma IGF-1:   227 ug/L ( 55-198 ) H
Plasma cortisol:   434 nmol/L ( 0600-1000 hrs 170-500 nmol/L )
HbA1c:   36 mmol/mol ( 20-40 )
LH:   <0.1 IU/L
FSH:   0.1 IU/L
DHT Plasma Dihydrotestosterone:   7455   pmol/L ( 223 ng/dl ) 
Reference Range Adult males  1000-6000 pmol/L

TForMe

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Re: Testosterone (TRT) Causes Calcification of the Arteries?
« Reply #3 on: May 19, 2016, 09:35:19 pm »

Recently heard an article on the radio station (Tech and medical slot) which has found that large testosterone levels potentially causes calcification and hardening in the artery walls of older males ie increased morbidity figures than those on TRT treatments.
http://medicalxpress.com/news/2016-04-links-heart-disease-testosterone.html

There are now 3 cardiovascular studies on humans that say the polar opposite and the Peak Testosterone site has a good summary here if you have not seen it:

http://www.peaktestosterone.com/testosterone_heart_disease

Testosterone has been shown to reduce hardening of the arteries, inflammation and insulin resistance.  It is hard to imagine that it would make arterial plaque worse.

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Re: Testosterone (TRT) Causes Calcification of the Arteries?
« Reply #3 on: May 19, 2016, 09:35:19 pm »


PeakT

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Re: Testosterone (TRT) Causes Calcification of the Arteries?
« Reply #4 on: May 20, 2016, 12:02:23 am »
I would guess this is a dosage thing.  Here are a couple of things to think about:

1.  Why is it that young men with high testosterone levels aren't dropping like flies and atherosclerosis is mostly a disease of the 40+ crowd?

2.  If you push your testosterone above 1200 ng/dl, there is evidence your HDL will start dropping.

Seriously, are the authors arguing that low testosterone will be good for heart disease?  Just doesn't make sense.
THE MOST COMPREHENSIVE BOOK ON TRT/TESTOSTERONE:
https://www.amazon.com/Natural-Versus-Testosterone-Therapy-Myer/dp/1523210532/ref=sr_1_1?ie=UTF8&qid=1499116128&sr=8-1&keywords=natural+versus+testosterone+therapy
And check out my New Peak Testosterone Program: http://www.peaktestosterone.com/peak_testosterone_program
If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements.  And low testosterone is a medical condition.

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Re: Testosterone (TRT) Causes Calcification of the Arteries?
« Reply #4 on: May 20, 2016, 12:02:23 am »