Testosterone (TRT) Causes Calcification of the Arteries?

[ghce]

Most of the time I read about guys they been on it for less than 10 years.. I'm 26... if lived to be 86 I would need to be on it for 60 years. This really trips me out....are there any guys who have been on it for 40... 30.. years? How has that worked out for you?

I asked a similar question earlier.    I've been on TRT now for 3 years, and I expect to stay on this for the rest of my life.    I'm in my late 50's.    I'm concerned about the consequences of having what could be an unnatural high T as I age; and it's impact on the aging process.     

Recently heard an article on the radio station (Tech and medical slot) which has found that large testosterone levels potentially causes calcification and hardening in the artery walls of older males ie increased morbidity figures than those on TRT treatments.
http://medicalxpress.com/news/2016-04-links-heart-disease-testosterone.html

[curious]

Most of the time I read about guys they been on it for less than 10 years.. I'm 26... if lived to be 86 I would need to be on it for 60 years. This really trips me out....are there any guys who have been on it for 40... 30.. years? How has that worked out for you?

I asked a similar question earlier.    I've been on TRT now for 3 years, and I expect to stay on this for the rest of my life.    I'm in my late 50's.    I'm concerned about the consequences of having what could be an unnatural high T as I age; and it's impact on the aging process.     

Recently heard an article on the radio station (Tech and medical slot) which has found that large testosterone levels potentially causes calcification and hardening in the artery walls of older males ie increased morbidity figures than those on TRT treatments.
http://medicalxpress.com/news/2016-04-links-heart-disease-testosterone.html

The study you are referencing is in mice, not humans. Further, it is not looking at endogenous versus exogenous testosterone but rather testosterone as a whole and makes no mention of older males. In my personal opinion, and I am not a doctor, I think if testosterone was inherently dangerous for the heart you would see young men developing cardiovascular disease.

[ghce]

Yes you are correct, not wishing to scare monger at all, but I feel that a study of this sort will lead to some more in-depth studies in the human population

[TForMe]

Recently heard an article on the radio station (Tech and medical slot) which has found that large testosterone levels potentially causes calcification and hardening in the artery walls of older males ie increased morbidity figures than those on TRT treatments.
http://medicalxpress.com/news/2016-04-links-heart-disease-testosterone.html

There are now 3 cardiovascular studies on humans that say the polar opposite and the Peak Testosterone site has a good summary here if you have not seen it:

http://www.peaktestosterone.com/testosterone_heart_disease

Testosterone has been shown to reduce hardening of the arteries, inflammation and insulin resistance.  It is hard to imagine that it would make arterial plaque worse.

[PeakT]

I would guess this is a dosage thing.  Here are a couple of things to think about:

1.  Why is it that young men with high testosterone levels aren't dropping like flies and atherosclerosis is mostly a disease of the 40+ crowd?

2.  If you push your testosterone above 1200 ng/dl, there is evidence your HDL will start dropping.

Seriously, are the authors arguing that low testosterone will be good for heart disease?  Just doesn't make sense.