Okay, the researchers involved in the Ecuadoran study that I have discussed on here have done a nice job of summarizing their findings. The results are SO powerful that I think finally everyone will finally understand the magnitude of their findings. I cannot tell you the number of times that I have read guys pushing IGF-1 for muscle growth and different things but check out below what happens when you have virtually none of the stuff:http://stm.sciencemag.org/content/3/70/70ra13.abstract
"Growth Hormone Receptor Deficiency Is Associated with a Major Reduction in Pro-Aging Signaling, Cancer, and Diabetes in Humans"
"Mutations in growth signaling pathways extend life span, as well as protect against age-dependent DNA damage in yeast and decrease insulin resistance and cancer in mice. To test their effect in humans, we monitored for 22 years Ecuadorian individuals who carry mutations in the growth hormone receptor (GHR) gene that lead to severe GHR and IGF-1 (insulin-like growth factor–1) deficiencies
"The individuals with GHR deficiency exhibited only one nonlethal malignancy and no cases of diabetes, in contrast to a prevalence of 17% for cancer and 5% for diabetes in control subjects
. A possible explanation for the very low incidence of cancer was suggested by in vitro studies: Serum from subjects with GHR deficiency reduced DNA breaks but increased apoptosis in human mammary epithelial cells treated with hydrogen peroxide. Serum from GHR-deficient subjects also caused reduced expression of RAS, PKA (protein kinase A), and TOR (target of rapamycin) and up-regulation of SOD2 (superoxide dismutase 2) in treated cells
, changes that promote cellular protection and life-span extension in model organisms."
Here are a few principles that may help those interested:
--Consuming less protein will lower IGF-1.
--IGF-1 can be raised by high carbs.
--IGF-1 will generally be lowered by plant proteins which tend to lower proportionately in methionine.
--IGF-1 can possibly be lowered by taking glycine. Is that safe long term? Don't know...
--IGF-1 can be lowered by consuming less overall protein which lowers methionine consumption
If you promote increasing IGF-1, then you might as well promote insulin. No one wants high insulin, right? But IGF-1 and insuin and sister molecules and have very similar properties.