Arimidex and Blood Pressure

[anonymous11]

Does Armidex lower blood pressure?

[PeakT]

Good q.  I don't think it does appreciably, but I don't know that for sure.  Estradiol definitely impacts arterial function somewhat though and can improve vasodilation to a point (which could improve blood pressure):

For example, they have long known that it helps in women:

http://www.ncbi.nlm.nih.gov/pubmed/22878703
"Ophthalmic artery vasodilation after intranasal estradiol use in postmenopausal women"

However, the same effect was found to hold in men as well:

http://www.ncbi.nlm.nih.gov/pubmed/11207631
"Oestradiol improves arterial endothelial function in healthy men receiving testosterone"

"Oestradiol produced a dose-dependent increase in plasma oestradiol (at 1 month 96 +/- 7, 149 +/- 6, 192 +/- 23 pmol/l in the 3 groups, respectively, P < 0.001 by ANOVA for trend). Minor side-effects (gynaecomastia, nipple tenderness) indicated that 20 mg oestradiol was the maximum tolerated dose. There was also a dose-dependent increase in FMD with oestradiol dose: at 1 month"

So it looks like estradiol will help blood flow (and blood pressure) in  men, but becomes unhealthy in other tissues when you get too high of a dosage.  This is not secret of course.

Now, in your case, your estradiol is lowish, so I don't think this really applies to you.  You were probably around 15, for example, during your low testosterone days.  Talk to your doc...

[anonymous11]

Contrary I naturally had high E2 readings and low T. They were super high when I started injections. My estrodiol was in the 90s after a month of shots. Then it went down to the 50s. Now after 3 months of Armidex, I am at 15.  I will lower the dose now and try to keep it around 20 because I am currently feeling great so I just want to raise it a tad. My blood pressure is the only dramatic change after I took the armidex. My lifestyle with diet, exercise and life were the same. In my opinion, the only thing that could of dropped it that low has to be the armidex. Not being hydrated is a factor but I do not believe it was a factor the would be so drastic of a change downwards. I feel fine however I think that number 87/67 is too low.

[PeakT]

Contrary I naturally had high E2 readings and low T. They were super high when I started injections. My estrodiol was in the 90s after a month of shots. Then it went down to the 50s. Now after 3 months of Armidex, I am at 15.  I will lower the dose now and try to keep it around 20 because I am currently feeling great so I just want to raise it a tad. My blood pressure is the only dramatic change after I took the armidex. My lifestyle with diet, exercise and life were the same. In my opinion, the only thing that could of dropped it that low has to be the armidex. Not being hydrated is a factor but I do not believe it was a factor the would be so drastic of a change downwards. I feel fine however I think that number 87/67 is too low.

Testosterone lowers blood pressure as well:

http://www.peaktestosterone.com/Testosterone_Blood_Pressure

How's the thyroid.  This can artificially lower blood pressure as well.  You don't seem to have the classic symptoms though...

[anonymous11]

What is the test call on blood work for thyroid? I will see if I was tested for it and what the reading was. If not, I will ask to be tested for it next time. From what I read online, the T4 (Thyroxine) tests the thyroid. My reading on my lab work says I am 5.4 and normal is from 4.4-12.4. I am GOOD TO GO!!!

[PeakT]

What is the test call on blood work for thyroid? I will see if I was tested for it and what the reading was. If not, I will ask to be tested for it next time. From what I read online, the T4 (Thyroxine) tests the thyroid. My reading on my lab work says I am 5.4 and normal is from 4.4-12.4. I am GOOD TO GO!!!

TSH, T3 and T4 are the usual "Big Three" but there are different forms.  More advanced tests include antibodies.  Btw, many practitioners would not say that just because you are in range, all is well necessarily.  It depends on symptoms and where you are in the range, etc.  What was your TSH?

I agree that's it's very unlikely anything is wrong there.  What I was really saying is that you might want to dig into the lowish blood pressure.  Notice that a common side effect of the hydrocodone can be lowered blood pressure:

http://www.webmd.com/drugs/drug-251-Hydrocodone-Acetaminophen+Oral?drugid=251&drugname=Hydrocodone-Acetaminophen+Oral&pagenumber=6

[anonymous11]

T4 is 5.4
TSH is 2.6

Both in normal range. I don't see the T3 on the lab work. I might have to ask for that next time.

[PeakT]

T4 is 5.4
TSH is 2.6

Both in normal range. I don't see the T3 on the lab work. I might have to ask for that next time.

Noted.  Btw, hydrocodone is contraindicated when you have low blood pressure?

http://www.pdrhealth.com/drugs/vicodin

Not trying to be obnoxious.  Just letting you know cuzz often docs don't discuss the important stuff cuzz they're busy or whatever else...

[anonymous11]

Noted...I do not understand why my blood pressure dropped from near normal of around 120/80 2 months ago to 87/67. I do feel really calm and collective. I don't get wired up like you would think because of take T injections. I am not an expert in any way but I would think that people who take weekly injections will have higher blood pressure because "roid rage" or being moody. Do you find it odd where I am the opposite with higher T levels but low blood pressure? I feel great but I just am curious of this. I do not get light heady or dizzy at all. I just feel very calm a lot. I would expect differently because of T shots. What are your thoughts with the way I am thinking?

[Prsartist]

While I'm sure my weekly injections raise me
To levels that are above the normal high end of 1100.
They are no where near the levels to produce ANY
"Roid rage"!

If anything I feel much calmer (and ALOT better) than when my T was low!
I was much more prone to yelling and flying off the handle when my body
Was starving for T in the upper 200's.

[JackAndy]

While I'm sure my weekly injections raise me
To levels that are above the normal high end of 1100.
They are no where near the levels to produce ANY
"Roid rage"!

If anything I feel much calmer (and ALOT better) than when my T was low!
I was much more prone to yelling and flying off the handle when my body
Was starving for T in the upper 200's.

Yep same here.

[PeakT]

Noted...I do not understand why my blood pressure dropped from near normal of around 120/80 2 months ago to 87/67. I do feel really calm and collective. I don't get wired up like you would think because of take T injections. I am not an expert in any way but I would think that people who take weekly injections will have higher blood pressure because "roid rage" or being moody. Do you find it odd where I am the opposite with higher T levels but low blood pressure? I feel great but I just am curious of this. I do not get light heady or dizzy at all. I just feel very calm a lot. I would expect differently because of T shots. What are your thoughts with the way I am thinking?

If you go too high, you can get aggressive and "snappy".  However, the testosterone-agrgression connection has been controversial in the studies:

http://www.peaktestosterone.com/Testosterone_Aggression

Again, testosterone will definitely lower your blood pressure, but I'm just surprised at what a change you are getting.  Just make sure you get checked out on that as you're pretty low and other weird things can cause it.

[anonymous11]

I am in the mid 750s for the last 3 months whier felt so calm ch I am good to go with. I never felt so calm in my life. Prsartist is right on the money. I was moody and bickering a lot when I had low T. I guess I never really understood what normal T will feel like. I had this imaginary vision in my head that I will be tough and more alpha male. In reality, I am so calm and cool to keep my composure. I never been like this before. It feels good but scares me because I was never like this. The low blood pressure reading through me off. I will continue to run and work out moderately and lower the dose of Armidex as I have been this week already. What I like the most of this feeling is not just the feeling of being strong and powerful in the gym, it is the libido and urge to be with my wife. For so long I been suffering and my wife dealt with so much of my crap. Hats off to her for her time and support.

[PeakT]

I am in the mid 750s for the last 3 months whier felt so calm ch I am good to go with. I never felt so calm in my life. Prsartist is right on the money. I was moody and bickering a lot when I had low T. I guess I never really understood what normal T will feel like. I had this imaginary vision in my head that I will be tough and more alpha male. In reality, I am so calm and cool to keep my composure. I never been like this before. It feels good but scares me because I was never like this. The low blood pressure reading through me off. I will continue to run and work out moderately and lower the dose of Armidex as I have been this week already. What I like the most of this feeling is not just the feeling of being strong and powerful in the gym, it is the libido and urge to be with my wife. For so long I been suffering and my wife dealt with so much of my crap. Hats off to her for her time and support.

And hats off to your doc:  he tuned you to the correct testosterone level it sounds like.

I hate to repeat myself, but higher testosterone animals have been shown to be "calmer".  It is the low testosterone animals that get in fights per a number of animal studies.