Hey, I think what is missing is this for Croaker:
How do we know there is not a saturation point at which Vitamin C no longer significantly stimulates collagen growth? In other words, what if all Vitamin C ingested over 100 mg does not contribute any more to collagen formation or repair?
For example, a saturation model seems to govern the testosterone prostate cancer relationship. So not everything is linear.
Now, retado, I know that it should based on the fact that other animals have greatly increased plasma levels because they essentially manufacture it. However, there still should be some evidence out there that this is the case in us humans.
And you know I megadose Vitamin C, so I'm largely on your side. But I am just pointing out why I think Croaker and others are asking questions.
" animals have greatly increased plasma levels because they essentially manufacture it"
--no they dont essentially manufacture it, THEY DO MAKE IT< quite literally
there are a lots of reasons why pauling therapy won't workhttp://www.internetwks.com/pauling/caveat.htm
a bigone is root canals or lots of oxidants coming into the body
dr levy goes into this in his book"TOXIC TOOTH"https://www.youtube.com/watch?v=EH6ndTMkDkY
I recall this being discussed on the vitC foundation site, and it's a reason why they and Dr levy say dont get root canals
too much garbage gets ito the body and thus uses up the vit C
A vast array of discoveries were forthcoming from that extensive and meticulous research which found many root canal therapy common beliefs of dentists and endodontists to be false. The most startling one clearly and emphatically demonstrated with 5,000 animal studies, that root canal filled teeth always remain infected no matter how good they look or how good they feel.http://www.smartcancertherapy.com/the-root-canal-coverup.html
here are other ways to get these microbes under control, and several are being tested at this time. It is advantageous to have intravenous vitamin C and occasionally a non-killing antibiotic is added to this solution. This combination does reduce the challenge to the immune system, but, overall, root canals represent the rock-and-hard-place situation.
Leave the root canal or cavitation in the body, and there is the potential of creating an unwanted autoimmune or degenerative disease that could be life threatening. Toxins and bacteria can both leak from these contamination sites wreaking havoc with a person’s cardiovascular, endocrine, nervous and immune systems. The public needs to be informed, so they can make educated choices in the trade-off between toxic convenience and health.http://www.westonaprice.org/holistic-healthcare/root-canal-dangers/
I think that's off point
so what are you asking?
how much is too much vit C?
it really varies
i recall I used to reach BT at 2-4 grams,, then I spent time with my parents, siblings and lil monsteros and I was easily taking 10g/day with no isses
the vit C foundation say got bowl toleranc
e BT and when you start having GI issues, then reduce that amount until you stop having issues
but how much vitC you take can easily change, depending on what you exposed to.
here's a link about studies to BThttp://vitamincfoundation.org/www.orthomed.com/titrate.htm
The maximum relief of symptoms which can be expected with oral doses of ascorbic acid is obtained at a point just short of the amount which produces diarrhea. The amount and the timing of the doses are usually sensed by the patient. The physician should not try to regulate exactly the amount and timing of these doses because the optimally effective dose will often change from dose to dose. Patients are instructed on the general principles of determining doses and given estimates of the reasonable starting amounts and timing of these doses. I have named this process of the patient determining the optimum dose, TITRATING TO BOWEL TOLERANCE. The patient tries to TITRATE between that amount which begins to make him feel better and that amount which almost but not quite causes diarrhea.
I think it is only that excess amount of ascorbate not absorbed into the body which causes diarrhea; what does not reach the rectum, does not cause diarrhea.