Pregnenolone/dhea/hcg lowered my progesterone!!!

[timmy11]

So,,,, I have been taking 20mg dhea and 30mg pregnenolone in a compounded tablet through defy medical.  Also, taking HCG 250units EOD.  Then, .10ml Tcyp EOD. 
 My dhea went up to 293 from 170.  That's good maybe want to go higher though.  My progesterone though went from .4 to .1!!!! This seems crazy.!!! I will be consulting with Defy soon.  I am waiting on other labs for Testosterone total and free.  Any thoughts on this!! I am thinking Dr saya will raise my dhea and put me on straight progesterone pills or cream??!! Thxx. PS.  I am tapering off clonazepam as well during all this.  It's been slow and painful, but just wanted to add that!!

[PeakT]

So,,,, I have been taking 20mg dhea and 30mg pregnenolone in a compounded tablet through defy medical.  Also, taking HCG 250units EOD.  Then, .10ml Tcyp EOD. 
 My dhea went up to 293 from 170.  That's good maybe want to go higher though.  My progesterone though went from .4 to .1!!!! This seems crazy.!!! I will be consulting with Defy soon.  I am waiting on other labs for Testosterone total and free.  Any thoughts on this!! I am thinking Dr saya will raise my dhea and put me on straight progesterone pills or cream??!! Thxx. PS.  I am tapering off clonazepam as well during all this.  It's been slow and painful, but just wanted to add that!!

Can't explain that one.  Let us know what happens.

[Kierkegaard]

So,,,, I have been taking 20mg dhea and 30mg pregnenolone in a compounded tablet through defy medical.  Also, taking HCG 250units EOD.  Then, .10ml Tcyp EOD. 
 My dhea went up to 293 from 170.  That's good maybe want to go higher though.  My progesterone though went from .4 to .1!!!! This seems crazy.!!! I will be consulting with Defy soon.  I am waiting on other labs for Testosterone total and free.  Any thoughts on this!! I am thinking Dr saya will raise my dhea and put me on straight progesterone pills or cream??!! Thxx. PS.  I am tapering off clonazepam as well during all this.  It's been slow and painful, but just wanted to add that!!

Could be a complicated example of a false correlation.  What really might be happening is your progesterone from pregnenolone is indeed going up -- albeit maybe by not much, YMMV -- but your higher demand for stress provided more cortisol, sucking up the extra progesterone exogenously given by pregnenolone.  Given that you've had issues with high cortisol and low progesterone in the past, I'd say this is a reasonable possibility. 

The question is what the stressor is.  Maybe it's the increase in norepinephrine from lowered GABA because you're tapering off a benzo.  But since you had this same high cortisol/low progesterone deal before tapering, it might be something else -- something you might not have pinned down yet. 

On a much more complicated note, I wonder if there are any supplements you can take to slow down the enzymes that convert progesterone to cortisol, 21 hydroxylase and 11B-hydroxylase. 

[PeakT]

So,,,, I have been taking 20mg dhea and 30mg pregnenolone in a compounded tablet through defy medical.  Also, taking HCG 250units EOD.  Then, .10ml Tcyp EOD. 
 My dhea went up to 293 from 170.  That's good maybe want to go higher though.  My progesterone though went from .4 to .1!!!! This seems crazy.!!! I will be consulting with Defy soon.  I am waiting on other labs for Testosterone total and free.  Any thoughts on this!! I am thinking Dr saya will raise my dhea and put me on straight progesterone pills or cream??!! Thxx. PS.  I am tapering off clonazepam as well during all this.  It's been slow and painful, but just wanted to add that!!

Also, read about "pregnenolone steal." 

[electrify]

Are these the same Progesterone tests? Asking bc the labcorp range for progesterone suddenly changed 2 months ago.

[timmy11]

Are these the same Progesterone tests? Asking bc the labcorp range for progesterone suddenly changed 2 months ago.

Yes, from Labcorp.  My labs are about 8 months apart so the range may have changed.  But the value of it still went down .

[timmy11]

The range did change from 0.0-0.1 for progesterone!!! Does this mean the value of my lab went up still?? Not sure if I understand it totally!!!

[electrify]

The range did change from 0.0-0.1 for progesterone!!! Does this mean the value of my lab went up still?? Not sure if I understand it totally!!!

No clue I just brought it up since I noticed that on my lab the range changed. I have no idea how it translates/converts to the old test.

[timmy11]

The range did change from 0.0-0.1 for progesterone!!! Does this mean the value of my lab went up still?? Not sure if I understand it totally!!!

No clue I just brought it up since I noticed that on my lab the range changed. I have no idea how it translates/converts to the old test.

On the old lab ranges I was stuck at 0.4!  I have no idea how this all translates? Am I at the top of the range now?? I assume so!

[farshad04]

yeah  benzo reduce progesterone do some googling .

[electrify]

yeah  benzo reduce progesterone do some googling .

Yea this is true my prog levels went down as well as cortisol in benzo wd. Came up after though.