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Author Topic: Synthetic and natural thyroid hormones bioidentical?  (Read 2617 times)

Sighalot

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Synthetic and natural thyroid hormones bioidentical?
« on: December 24, 2016, 04:26:53 am »
I have heard time and time again from health care that synthetic and natural thyroid hormones are bio identical but are they? recently i read an article that claimed there are differences.

Synthetic hormones are free while natural hormones are bound, if a synthetic t4 molecule is 1mm big then a natural t4 molecule is in comparison over 10cm big.

Anyone else read anything about this?
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/Sighalot

PeakT

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Re: Synthetic and natural thyroid hormones bioidentical?
« Reply #1 on: December 24, 2016, 04:39:12 pm »
Bump...
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Re: Synthetic and natural thyroid hormones bioidentical?
« Reply #1 on: December 24, 2016, 04:39:12 pm »


Sighalot

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Re: Synthetic and natural thyroid hormones bioidentical?
« Reply #2 on: December 25, 2016, 01:17:40 am »
Thoughts?




Instead, it was about a bio-analytical chemist who decided to test synthetic T3 (Cynomel and Cynoplus) as well as the Thailand-made Natural Desiccated Thyroid (NDT) called Thyroid-S, by extracting each tablet with methanol, then diluting and injecting them on an LC/MS system–a sensitive instrument used to detect and identify compounds and molecules in a substance.

And what he discovered and reported is that the thyroid hormones of NDT are tightly bound with thyroglobulin, a large iodine-containing protein….whereas synthetics are bound by nothing. i.e. synthetic hormones are exposed; NDT hormones are protected (until they are released by your digestion).   The diagram on this blog post gives you a powerful visual of this reality, but specifically in comparing natural desiccated thyroid with synthetic T4-only. You will see the large mass of thyroglobulin on the left, each containing either T4, T3, T2, T1 or calcitonin within. Then the tiny synthetic hormone on the right, alone.

But is that bad NOT be bound by thyroglobulin??  Possibly yes in the opinion of Peter. As Peter explained:  “The [exposed] synthetics might be affected by stomach acids in different ways in different people.  Low acid, high acid, various digestive and pancreatic enzymes in varying amounts, bacteria/flora in the stomach and small intestine, all kinds of possibilities here which would vary by the person.”  And, he says, that can mean instability!

Peter continues:  “Perhaps the thyroglobulin in NDT (and completely missing in the synthetics) is absorbed, or necessary, or utilized, or forms other products during digestion that could affect blood levels of various substances, numerous carrier proteins for example, thereby affecting the results obtained.”  And he concludes:  “The NDT hormones are bound to thyroglobulin and not available for reaction or breakdown until after they first digested (from Janie: which saliva begins, by the way, even in your mouth).  This would be a more stable compound.”  His original post is here.

http://www.stopthethyroidmadness.com/2012/06/17/chemical-analysis-showing-difference-between-ndt-and-t4-only/

Joe Sixpack

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Re: Synthetic and natural thyroid hormones bioidentical?
« Reply #3 on: December 25, 2016, 05:33:44 am »
I have no way of knowing the chemistry properties of these molecules.  But it's not really an apples to apples comparison if you are looking at NDT vs Synthroid or any other T4 only drugs.  Same w/ comparing Cytomel (T3) to NDT.  NDT has a combination of T1, T2, T3 and T4.  So a comparisons of synthetic T4 to NDT w/ T1, T2, T3 and T4 would always be different, even if the binding of thyroglobulin is not a factor. 

Wonder if a consumer would feel any differences if they took a synthetic T4, T3 combo, in the same ratio as what the NDT has?
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Re: Synthetic and natural thyroid hormones bioidentical?
« Reply #3 on: December 25, 2016, 05:33:44 am »


PeakT

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Re: Synthetic and natural thyroid hormones bioidentical?
« Reply #4 on: December 25, 2016, 03:21:01 pm »
That is interesting as thyrglobulin itself has been studied:

https://www.ncbi.nlm.nih.gov/m/pubmed/3558731/

Thyroglobulin has its own effect on the thyroid:

https://en.m.wikipedia.org/wiki/Thyroglobulin

This seems to talk about the above?

https://www.ncbi.nlm.nih.gov/m/pubmed/3918854/


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https://www.amazon.com/Natural-Versus-Testosterone-Therapy-Myer/dp/1523210532/ref=sr_1_1?ie=UTF8&qid=1499116128&sr=8-1&keywords=natural+versus+testosterone+therapy
And check out my New Peak Testosterone Program: http://www.peaktestosterone.com/peak_testosterone_program
If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements.  And low testosterone is a medical condition.

Sighalot

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Re: Synthetic and natural thyroid hormones bioidentical?
« Reply #5 on: December 25, 2016, 10:34:27 pm »
Wonder if a consumer would feel any differences if they took a synthetic T4, T3 combo, in the same ratio as what the NDT has?
Where i live its a requirement to use t3+t4 medication for one year before a license for ndt can be approved and i have meet many that say they feel better with ndt.

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Re: Synthetic and natural thyroid hormones bioidentical?
« Reply #5 on: December 25, 2016, 10:34:27 pm »