Im recently diagnosed with Myalgic Encephalomyelitis and lately i have read lots and lots of claims that ME often is caused by chronic infections and lyme is pretty high up on the list, one part of this is that chronic infections can cause the immune system to break down.
I have hypothyrodism but all tests looks ok on paper, free t4 low in range, free t3 midrange and tsh mid to high in range and no antibodies so im medicated because of positive effects, can chronic infections cause hypothyrodism?
Testosteron deficiency, also this is a bit unclear health care claims its weight related which i dont buy since T dropped with over 50% between 2004 and 2009 while my weight was about the same, can chronic infections cause low T?
Cortisol, again on paper it looks ok usually mid range and result of synactentest was good but when i tried hydrocortisone i got effects like better sleep, less hungry, lower blood sugar, lower heart rate, lower blood pressure, more energy..can it be related to chronic infections?
Curious, how were you diagnosed with ME? Do your doctors (or yourself) consider it pretty much synonymous with chronic fatigue in terms of symptoms (I rec the site Phoenix Rising either way, great folks there).
Hypothyroidism is especially one of those things where the range is probably a good deal broader than it should be for many reasons I won't get into, but notably how many people who have hypothyroidism are included in the range (which broadens it), and since the 80s or so there's been a shift from diagnosing hypothyroidism based on symptoms primarily and labwork secondarily to going the "numerology" route and just focusing on labs, which is problematic given that there a good fraction of people out there who have clear hypothyroid symptoms (particularly a slow ankle reflex and/or low basal body temps below 97.8 degrees first thing before getting out of bed). I say all this to say that low free T4, mid-high TSH, and even middling free T3 aren't good enough for a lot of people; Dr Mariano said my free T3 levels of 3.3 (before treatment) were "livable", for example, whereas the vast majority of dos (who again are almost always numerologists) would say this is more than fine. So I'd recommend a trial of NDT, T3, or even T4 meds.
Getting positive effects from hydrocortisone (provided it isn't in the pharmacological range, usually above 40 mg per day for most people, where pretty much everyone would feel better in some ways) is a strong indicator that you're in need of hydrocortisone. So, you know. You might also try pregnenolone and DHEA if you haven't already, but if the former makes you feel worse, then I'd just try HC again.
Chronic infections can basically put your body in a chronic inflammatory state, which can cause sympathetic activation, which by itself or other biochemical mediators from chronic inflammation can lower your hormones, including sex, thyroid, and adrenal hormones. So you might have a root to really investigate, but until then it might be worth trying the semi-bandaids (I say semi because they're pretty deep responses just not to the root) of thyroid meds, HC, and/or testosterone with your doc's supervision.
I say everyone should be given a trial for pretty much any hormone provided they show at least a few telling symptoms for it.